Alteration of Pituitary Tumor Transforming Gene-1 Regulates Trophoblast Invasion via the Integrin/Rho-Family Signaling Pathway

Trophoblast invasion ability is an important factor in early implantation and placental development. Recently, pituitary tumor transforming gene 1 (PTTG1) was shown to be involved in invasion and proliferation of cancer. However, the role of PTTG1 in trophoblast invasion remains unknown. Thus, in th...

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Veröffentlicht in:	PloS one 2016-02, Vol.11 (2), p.e0149371-e0149371
Hauptverfasser:	Lim, Seung Mook, Jang, Hee Yeon, Lee, Ji Eun, Shin, Joong Sik, Park, Sun-Hwa, Yoon, Bo Hyun, Kim, Gi Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	Achievement tests Antigens Biology and Life Sciences Brain cancer Cancer Cell adhesion & migration Cell cycle Cell Line Cell Proliferation Flow cytometry Fluorescence Gelatinase B Gene expression Gene Expression Regulation Gynecology Humans Hypoxia Implantation Inhibitors Integrins - biosynthesis Integrins - genetics Kinases Lung cancer Matrix metalloproteinase Matrix Metalloproteinase 2 - biosynthesis Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 9 - biosynthesis Matrix Metalloproteinase 9 - genetics Medical research Medicine Medicine and Health Sciences Metalloproteinase MicroRNAs MicroRNAs - biosynthesis MicroRNAs - genetics miRNA Obstetrics Penicillin Pituitary Pituitary gland Pituitary tumor-transforming proteins Placenta Polymerase chain reaction Pregnancy rhoA GTP-Binding Protein - biosynthesis rhoA GTP-Binding Protein - genetics RhoA protein Ribonucleic acid RNA Science Securin - genetics Securin - metabolism Senescence Signal transduction siRNA Trophoblasts Trophoblasts - cytology Trophoblasts - metabolism Tumors
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