Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood-Stage Proteins of Plasmodium vivax
The development of an effective immune response can help decrease mortality from malaria and its clinical symptoms. However, this mechanism is complex and has significant inter-individual variation, most likely owing to the genetic contribution of the human host. Therefore, this study aimed to inves...
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| creator | Cassiano, Gustavo C Furini, Adriana A C Capobianco, Marcela P Storti-Melo, Luciane M Cunha, Maristela G Kano, Flora S Carvalho, Luzia H Soares, Irene S Santos, Sidney E Póvoa, Marinete M Machado, Ricardo L D |
| description | The development of an effective immune response can help decrease mortality from malaria and its clinical symptoms. However, this mechanism is complex and has significant inter-individual variation, most likely owing to the genetic contribution of the human host. Therefore, this study aimed to investigate the influence of polymorphisms in genes involved in the costimulation of B-lymphocytes in the naturally acquired humoral immune response against proteins of the asexual stage of Plasmodium vivax. A total of 319 individuals living in an area of malaria transmission in the Brazilian Amazon were genotyped for four SNPs in the genes CD40, CD40L, BLYS and CD86. In addition, IgG antibodies against P. vivax apical membrane antigen 1 (PvAMA-1), Duffy binding protein (PvDBP) and merozoite surface protein 1 (PvMSP-119) were detected by ELISA. The SNP BLYS -871C>T was associated with the frequency of IgG responders to PvAMA-1 and PvMSP-119. The SNP CD40 -1C>T was associated with the IgG response against PvDBP, whereas IgG antibody titers against PvMSP-119 were influenced by the polymorphism CD86 +1057G>A. These data may help to elucidate the immunological aspects of vivax malaria and consequently assist in the design of malaria vaccines. |
| doi_str_mv | 10.1371/journal.pone.0149581 |
| format | Article |
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However, this mechanism is complex and has significant inter-individual variation, most likely owing to the genetic contribution of the human host. Therefore, this study aimed to investigate the influence of polymorphisms in genes involved in the costimulation of B-lymphocytes in the naturally acquired humoral immune response against proteins of the asexual stage of Plasmodium vivax. A total of 319 individuals living in an area of malaria transmission in the Brazilian Amazon were genotyped for four SNPs in the genes CD40, CD40L, BLYS and CD86. In addition, IgG antibodies against P. vivax apical membrane antigen 1 (PvAMA-1), Duffy binding protein (PvDBP) and merozoite surface protein 1 (PvMSP-119) were detected by ELISA. The SNP BLYS -871C>T was associated with the frequency of IgG responders to PvAMA-1 and PvMSP-119. The SNP CD40 -1C>T was associated with the IgG response against PvDBP, whereas IgG antibody titers against PvMSP-119 were influenced by the polymorphism CD86 +1057G>A. These data may help to elucidate the immunological aspects of vivax malaria and consequently assist in the design of malaria vaccines.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0149581</identifier><identifier>PMID: 26901523</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Aged ; Antibodies, Protozoan - immunology ; Antigens ; Antigens, CD - genetics ; Antigens, CD - immunology ; Apical membrane antigen 1 ; B cells ; Biology ; Biology and Life Sciences ; BLyS protein ; CD40 antigen ; CD40L protein ; CD86 antigen ; Disease transmission ; Enzyme-linked immunosorbent assay ; Female ; Genes ; Genetic aspects ; Genomes ; Health aspects ; Humans ; IgG antibody ; Immune response ; Immune response (humoral) ; Immune system ; Immunoglobulin G ; Immunoglobulin G - immunology ; Immunoglobulins ; Immunological aspects ; Immunology ; Laboratories ; Lymphocytes ; Lymphocytes B ; Malaria ; Malaria, Vivax - genetics ; Malaria, Vivax - immunology ; Male ; Medicine and Health Sciences ; Merozoite surface protein 1 ; Middle Aged ; Parasites ; Parasitic diseases ; Parasitology ; Physiological aspects ; Plasmodium falciparum ; Plasmodium vivax ; Plasmodium vivax - immunology ; Polymorphism ; Polymorphism, Single Nucleotide - immunology ; Proteins ; Protozoan Proteins - immunology ; Research and Analysis Methods ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism ; Tumor necrosis factor-TNF ; Vaccines ; Vector-borne diseases</subject><ispartof>PloS one, 2016-02, Vol.11 (2), p.e0149581-e0149581</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Cassiano et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Cassiano et al 2016 Cassiano et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-513cc55aa51856732815d3c84a070c3cbfec1c799e064539bb4230f0801d87663</citedby><cites>FETCH-LOGICAL-c692t-513cc55aa51856732815d3c84a070c3cbfec1c799e064539bb4230f0801d87663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763038/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763038/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23871,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26901523$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Rénia, Laurent</contributor><creatorcontrib>Cassiano, Gustavo C</creatorcontrib><creatorcontrib>Furini, Adriana A C</creatorcontrib><creatorcontrib>Capobianco, Marcela P</creatorcontrib><creatorcontrib>Storti-Melo, Luciane M</creatorcontrib><creatorcontrib>Cunha, Maristela G</creatorcontrib><creatorcontrib>Kano, Flora S</creatorcontrib><creatorcontrib>Carvalho, Luzia H</creatorcontrib><creatorcontrib>Soares, Irene S</creatorcontrib><creatorcontrib>Santos, Sidney E</creatorcontrib><creatorcontrib>Póvoa, Marinete M</creatorcontrib><creatorcontrib>Machado, Ricardo L D</creatorcontrib><title>Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood-Stage Proteins of Plasmodium vivax</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The development of an effective immune response can help decrease mortality from malaria and its clinical symptoms. However, this mechanism is complex and has significant inter-individual variation, most likely owing to the genetic contribution of the human host. Therefore, this study aimed to investigate the influence of polymorphisms in genes involved in the costimulation of B-lymphocytes in the naturally acquired humoral immune response against proteins of the asexual stage of Plasmodium vivax. A total of 319 individuals living in an area of malaria transmission in the Brazilian Amazon were genotyped for four SNPs in the genes CD40, CD40L, BLYS and CD86. In addition, IgG antibodies against P. vivax apical membrane antigen 1 (PvAMA-1), Duffy binding protein (PvDBP) and merozoite surface protein 1 (PvMSP-119) were detected by ELISA. The SNP BLYS -871C>T was associated with the frequency of IgG responders to PvAMA-1 and PvMSP-119. The SNP CD40 -1C>T was associated with the IgG response against PvDBP, whereas IgG antibody titers against PvMSP-119 were influenced by the polymorphism CD86 +1057G>A. These data may help to elucidate the immunological aspects of vivax malaria and consequently assist in the design of malaria vaccines.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antibodies, Protozoan - immunology</subject><subject>Antigens</subject><subject>Antigens, CD - genetics</subject><subject>Antigens, CD - immunology</subject><subject>Apical membrane antigen 1</subject><subject>B cells</subject><subject>Biology</subject><subject>Biology and Life Sciences</subject><subject>BLyS protein</subject><subject>CD40 antigen</subject><subject>CD40L protein</subject><subject>CD86 antigen</subject><subject>Disease transmission</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Female</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genomes</subject><subject>Health aspects</subject><subject>Humans</subject><subject>IgG antibody</subject><subject>Immune response</subject><subject>Immune response (humoral)</subject><subject>Immune system</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin G - immunology</subject><subject>Immunoglobulins</subject><subject>Immunological aspects</subject><subject>Immunology</subject><subject>Laboratories</subject><subject>Lymphocytes</subject><subject>Lymphocytes B</subject><subject>Malaria</subject><subject>Malaria, Vivax - genetics</subject><subject>Malaria, Vivax - immunology</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Merozoite surface protein 1</subject><subject>Middle Aged</subject><subject>Parasites</subject><subject>Parasitic diseases</subject><subject>Parasitology</subject><subject>Physiological aspects</subject><subject>Plasmodium falciparum</subject><subject>Plasmodium vivax</subject><subject>Plasmodium vivax - immunology</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide - immunology</subject><subject>Proteins</subject><subject>Protozoan Proteins - immunology</subject><subject>Research and Analysis Methods</subject><subject>Single nucleotide polymorphisms</subject><subject>Single-nucleotide polymorphism</subject><subject>Tumor necrosis factor-TNF</subject><subject>Vaccines</subject><subject>Vector-borne 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diseases</topic><topic>Parasitology</topic><topic>Physiological aspects</topic><topic>Plasmodium falciparum</topic><topic>Plasmodium vivax</topic><topic>Plasmodium vivax - immunology</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide - immunology</topic><topic>Proteins</topic><topic>Protozoan Proteins - immunology</topic><topic>Research and Analysis Methods</topic><topic>Single nucleotide polymorphisms</topic><topic>Single-nucleotide polymorphism</topic><topic>Tumor necrosis factor-TNF</topic><topic>Vaccines</topic><topic>Vector-borne diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cassiano, Gustavo C</creatorcontrib><creatorcontrib>Furini, Adriana A C</creatorcontrib><creatorcontrib>Capobianco, Marcela P</creatorcontrib><creatorcontrib>Storti-Melo, Luciane M</creatorcontrib><creatorcontrib>Cunha, Maristela G</creatorcontrib><creatorcontrib>Kano, Flora S</creatorcontrib><creatorcontrib>Carvalho, Luzia 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C</au><au>Capobianco, Marcela P</au><au>Storti-Melo, Luciane M</au><au>Cunha, Maristela G</au><au>Kano, Flora S</au><au>Carvalho, Luzia H</au><au>Soares, Irene S</au><au>Santos, Sidney E</au><au>Póvoa, Marinete M</au><au>Machado, Ricardo L D</au><au>Rénia, Laurent</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood-Stage Proteins of Plasmodium vivax</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-02-22</date><risdate>2016</risdate><volume>11</volume><issue>2</issue><spage>e0149581</spage><epage>e0149581</epage><pages>e0149581-e0149581</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The development of an effective immune response can help decrease mortality from malaria and its clinical symptoms. However, this mechanism is complex and has significant inter-individual variation, most likely owing to the genetic contribution of the human host. Therefore, this study aimed to investigate the influence of polymorphisms in genes involved in the costimulation of B-lymphocytes in the naturally acquired humoral immune response against proteins of the asexual stage of Plasmodium vivax. A total of 319 individuals living in an area of malaria transmission in the Brazilian Amazon were genotyped for four SNPs in the genes CD40, CD40L, BLYS and CD86. In addition, IgG antibodies against P. vivax apical membrane antigen 1 (PvAMA-1), Duffy binding protein (PvDBP) and merozoite surface protein 1 (PvMSP-119) were detected by ELISA. The SNP BLYS -871C>T was associated with the frequency of IgG responders to PvAMA-1 and PvMSP-119. The SNP CD40 -1C>T was associated with the IgG response against PvDBP, whereas IgG antibody titers against PvMSP-119 were influenced by the polymorphism CD86 +1057G>A. These data may help to elucidate the immunological aspects of vivax malaria and consequently assist in the design of malaria vaccines.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26901523</pmid><doi>10.1371/journal.pone.0149581</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2016-02, Vol.11 (2), p.e0149581-e0149581 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1950593056 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adult Aged Antibodies, Protozoan - immunology Antigens Antigens, CD - genetics Antigens, CD - immunology Apical membrane antigen 1 B cells Biology Biology and Life Sciences BLyS protein CD40 antigen CD40L protein CD86 antigen Disease transmission Enzyme-linked immunosorbent assay Female Genes Genetic aspects Genomes Health aspects Humans IgG antibody Immune response Immune response (humoral) Immune system Immunoglobulin G Immunoglobulin G - immunology Immunoglobulins Immunological aspects Immunology Laboratories Lymphocytes Lymphocytes B Malaria Malaria, Vivax - genetics Malaria, Vivax - immunology Male Medicine and Health Sciences Merozoite surface protein 1 Middle Aged Parasites Parasitic diseases Parasitology Physiological aspects Plasmodium falciparum Plasmodium vivax Plasmodium vivax - immunology Polymorphism Polymorphism, Single Nucleotide - immunology Proteins Protozoan Proteins - immunology Research and Analysis Methods Single nucleotide polymorphisms Single-nucleotide polymorphism Tumor necrosis factor-TNF Vaccines Vector-borne diseases |
| title | Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood-Stage Proteins of Plasmodium vivax |
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