Chronic Administration of Benzo(a)pyrene Induces Memory Impairment and Anxiety-Like Behavior and Increases of NR2B DNA Methylation

Recently, an increasing number of human and animal studies have reported that exposure to benzo(a)pyrene (BaP) induces neurological abnormalities and is also associated with adverse effects, such as tumor formation, immunosuppression, teratogenicity, and hormonal disorders. However, the exact mechan...

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Veröffentlicht in:	PloS one 2016-02, Vol.11 (2), p.e0149574
Hauptverfasser:	Zhang, Wenping, Tian, Fengjie, Zheng, Jinping, Li, Senlin, Qiang, Mei
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Alzheimer's disease Animal cognition Animals Anxiety Anxiety - chemically induced Anxiety - metabolism Anxiety - pathology Anxiety - physiopathology Behavior, Animal - drug effects Benzo(a)pyrene Benzo(a)pyrene - toxicity Benzopyrene Biology and life sciences Bipolar disorder Brain Brain research Deoxyribonucleic acid DNA DNA methylation DNA Methylation - drug effects Down-regulation Emotional behavior Epigenetics Experiments Exposure Field tests Gene expression Glutamic acid receptors (ionotropic) Hippocampus - metabolism Hippocampus - pathology Hippocampus - physiopathology Humans Immunosuppression Impairment Male Medicine and Health Sciences Memory Memory disorders Memory Disorders - chemically induced Memory Disorders - metabolism Memory Disorders - pathology Memory Disorders - physiopathology Mice N-Methyl-D-aspartic acid receptors Neurological complications Neurophysiology Neurotoxicity Oils & fats Olive oil PCB Physiological aspects Pollutants Polychlorinated biphenyls Polycyclic aromatic hydrocarbons Prefrontal cortex Prefrontal Cortex - metabolism Prefrontal Cortex - pathology Prefrontal Cortex - physiopathology Public health Pyrene Receptors, N-Methyl-D-Aspartate - metabolism Research and Analysis Methods Risk factors Rodents Short term memory Studies Teratogenicity Toxicants Water pollution effects
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