Efficacy of carbonic anhydrase inhibitors in management of cystoid macular edema in retinitis pigmentosa: A meta-analysis
Carbonic anhydrase inhibitors (CAI) are often used in the treatment of cystoid macular edema (CME) in retinitis pigmentosa (RP) patients. The aim of this meta-analysis is to gain a better understanding of the overall efficacy of CAI treatment. Databases including PubMed, EMBASE, and Cochrane Library...
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| description | Carbonic anhydrase inhibitors (CAI) are often used in the treatment of cystoid macular edema (CME) in retinitis pigmentosa (RP) patients. The aim of this meta-analysis is to gain a better understanding of the overall efficacy of CAI treatment.
Databases including PubMed, EMBASE, and Cochrane Library were searched to identify relevant studies. Eligible studies were clinical trials of patients with RP assigned topical or oral CAIs such as dorzolamide and acetazolamide. Changes in central macular thickness (CMT) by OCT in μm and best-corrected visual acuity (BCVA) in log MAR equivalents were extracted and results compared between baseline and after treatment.
11 clinical reports were identified which included a total of 194 patients (358 eyes) available for analysis, with 59 patients (115 eyes) assigned oral CAI treatment and 135 patients (243 eyes) assigned topical CAI treatment. The combined results showed a significant reduction of macular edema, as calculated by baseline and final central macular thickness (CMT) based on OCT examination (46.02μm, 95%CI: -60.96, -31.08, I2 = 65%). However, the effect on visual acuity was inconsistent across studies.
Based on non randomized controlled clinical studies, RP patients with CME who were treated with CAIs had better anatomical outcomes, but the effect on visual acuity was contradictory across studies. Multicenter prospective randomized controlled trials would be ideal to definitively test its clinical efficacy in RP patients. |
| doi_str_mv | 10.1371/journal.pone.0186180 |
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Databases including PubMed, EMBASE, and Cochrane Library were searched to identify relevant studies. Eligible studies were clinical trials of patients with RP assigned topical or oral CAIs such as dorzolamide and acetazolamide. Changes in central macular thickness (CMT) by OCT in μm and best-corrected visual acuity (BCVA) in log MAR equivalents were extracted and results compared between baseline and after treatment.
11 clinical reports were identified which included a total of 194 patients (358 eyes) available for analysis, with 59 patients (115 eyes) assigned oral CAI treatment and 135 patients (243 eyes) assigned topical CAI treatment. The combined results showed a significant reduction of macular edema, as calculated by baseline and final central macular thickness (CMT) based on OCT examination (46.02μm, 95%CI: -60.96, -31.08, I2 = 65%). However, the effect on visual acuity was inconsistent across studies.
Based on non randomized controlled clinical studies, RP patients with CME who were treated with CAIs had better anatomical outcomes, but the effect on visual acuity was contradictory across studies. Multicenter prospective randomized controlled trials would be ideal to definitively test its clinical efficacy in RP patients.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0186180</identifier><identifier>PMID: 29023491</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acetazolamide ; Acetazolamide - administration & dosage ; Acetazolamide - pharmacology ; Acuity ; Administration, Oral ; Administration, Topical ; Biology and Life Sciences ; Carbonic anhydrase ; Carbonic anhydrase inhibitors ; Carbonic Anhydrase Inhibitors - administration & dosage ; Carbonic Anhydrase Inhibitors - pharmacology ; Carbonic anhydrases ; Clinical trials ; Clinical Trials as Topic ; Cohort analysis ; Complications and side effects ; Cystoid macular edema ; Dosage and administration ; Drug therapy ; Edema ; Effectiveness ; Eye (anatomy) ; Female ; Humans ; Identification methods ; Inhibitors ; Intervention ; Libraries ; Macular Edema - drug therapy ; Male ; Medical research ; Medicine and Health Sciences ; Meta-analysis ; Patients ; Physical Sciences ; Prospective Studies ; Quality ; Randomization ; Research and Analysis Methods ; Retina ; Retinitis ; Retinitis pigmentosa ; Retinitis Pigmentosa - complications ; Risk factors ; Social Sciences ; Statistical analysis ; Studies ; Sulfonamides - administration & dosage ; Sulfonamides - pharmacology ; Thiophenes - administration & dosage ; Thiophenes - pharmacology ; Tomography ; Treatment Outcome ; Visual acuity ; Visual Acuity - drug effects ; Visual effects ; Visual perception</subject><ispartof>PloS one, 2017-10, Vol.12 (10), p.e0186180-e0186180</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Huang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Huang et al 2017 Huang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-5289a279bae5e9c871ed62b37621a46aec7f8284957897290a07882657996e853</citedby><cites>FETCH-LOGICAL-c692t-5289a279bae5e9c871ed62b37621a46aec7f8284957897290a07882657996e853</cites><orcidid>0000-0002-3969-6805</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638411/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638411/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2919,23857,27915,27916,53782,53784,79361,79362</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29023491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Virgili, Gianni</contributor><creatorcontrib>Huang, Qinzhu</creatorcontrib><creatorcontrib>Chen, Ru</creatorcontrib><creatorcontrib>Lin, Xianping</creatorcontrib><creatorcontrib>Xiang, Zhenyang</creatorcontrib><title>Efficacy of carbonic anhydrase inhibitors in management of cystoid macular edema in retinitis pigmentosa: A meta-analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Carbonic anhydrase inhibitors (CAI) are often used in the treatment of cystoid macular edema (CME) in retinitis pigmentosa (RP) patients. The aim of this meta-analysis is to gain a better understanding of the overall efficacy of CAI treatment.
Databases including PubMed, EMBASE, and Cochrane Library were searched to identify relevant studies. Eligible studies were clinical trials of patients with RP assigned topical or oral CAIs such as dorzolamide and acetazolamide. Changes in central macular thickness (CMT) by OCT in μm and best-corrected visual acuity (BCVA) in log MAR equivalents were extracted and results compared between baseline and after treatment.
11 clinical reports were identified which included a total of 194 patients (358 eyes) available for analysis, with 59 patients (115 eyes) assigned oral CAI treatment and 135 patients (243 eyes) assigned topical CAI treatment. The combined results showed a significant reduction of macular edema, as calculated by baseline and final central macular thickness (CMT) based on OCT examination (46.02μm, 95%CI: -60.96, -31.08, I2 = 65%). However, the effect on visual acuity was inconsistent across studies.
Based on non randomized controlled clinical studies, RP patients with CME who were treated with CAIs had better anatomical outcomes, but the effect on visual acuity was contradictory across studies. Multicenter prospective randomized controlled trials would be ideal to definitively test its clinical efficacy in RP patients.</description><subject>Acetazolamide</subject><subject>Acetazolamide - administration & dosage</subject><subject>Acetazolamide - pharmacology</subject><subject>Acuity</subject><subject>Administration, Oral</subject><subject>Administration, Topical</subject><subject>Biology and Life Sciences</subject><subject>Carbonic anhydrase</subject><subject>Carbonic anhydrase inhibitors</subject><subject>Carbonic Anhydrase Inhibitors - administration & dosage</subject><subject>Carbonic Anhydrase Inhibitors - pharmacology</subject><subject>Carbonic anhydrases</subject><subject>Clinical trials</subject><subject>Clinical Trials as Topic</subject><subject>Cohort analysis</subject><subject>Complications and side effects</subject><subject>Cystoid macular edema</subject><subject>Dosage and administration</subject><subject>Drug therapy</subject><subject>Edema</subject><subject>Effectiveness</subject><subject>Eye (anatomy)</subject><subject>Female</subject><subject>Humans</subject><subject>Identification methods</subject><subject>Inhibitors</subject><subject>Intervention</subject><subject>Libraries</subject><subject>Macular Edema - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Qinzhu</au><au>Chen, Ru</au><au>Lin, Xianping</au><au>Xiang, Zhenyang</au><au>Virgili, Gianni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of carbonic anhydrase inhibitors in management of cystoid macular edema in retinitis pigmentosa: A meta-analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-10-12</date><risdate>2017</risdate><volume>12</volume><issue>10</issue><spage>e0186180</spage><epage>e0186180</epage><pages>e0186180-e0186180</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Carbonic anhydrase inhibitors (CAI) are often used in the treatment of cystoid macular edema (CME) in retinitis pigmentosa (RP) patients. The aim of this meta-analysis is to gain a better understanding of the overall efficacy of CAI treatment.
Databases including PubMed, EMBASE, and Cochrane Library were searched to identify relevant studies. Eligible studies were clinical trials of patients with RP assigned topical or oral CAIs such as dorzolamide and acetazolamide. Changes in central macular thickness (CMT) by OCT in μm and best-corrected visual acuity (BCVA) in log MAR equivalents were extracted and results compared between baseline and after treatment.
11 clinical reports were identified which included a total of 194 patients (358 eyes) available for analysis, with 59 patients (115 eyes) assigned oral CAI treatment and 135 patients (243 eyes) assigned topical CAI treatment. The combined results showed a significant reduction of macular edema, as calculated by baseline and final central macular thickness (CMT) based on OCT examination (46.02μm, 95%CI: -60.96, -31.08, I2 = 65%). However, the effect on visual acuity was inconsistent across studies.
Based on non randomized controlled clinical studies, RP patients with CME who were treated with CAIs had better anatomical outcomes, but the effect on visual acuity was contradictory across studies. Multicenter prospective randomized controlled trials would be ideal to definitively test its clinical efficacy in RP patients.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29023491</pmid><doi>10.1371/journal.pone.0186180</doi><tpages>e0186180</tpages><orcidid>https://orcid.org/0000-0002-3969-6805</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acetazolamide Acetazolamide - administration & dosage Acetazolamide - pharmacology Acuity Administration, Oral Administration, Topical Biology and Life Sciences Carbonic anhydrase Carbonic anhydrase inhibitors Carbonic Anhydrase Inhibitors - administration & dosage Carbonic Anhydrase Inhibitors - pharmacology Carbonic anhydrases Clinical trials Clinical Trials as Topic Cohort analysis Complications and side effects Cystoid macular edema Dosage and administration Drug therapy Edema Effectiveness Eye (anatomy) Female Humans Identification methods Inhibitors Intervention Libraries Macular Edema - drug therapy Male Medical research Medicine and Health Sciences Meta-analysis Patients Physical Sciences Prospective Studies Quality Randomization Research and Analysis Methods Retina Retinitis Retinitis pigmentosa Retinitis Pigmentosa - complications Risk factors Social Sciences Statistical analysis Studies Sulfonamides - administration & dosage Sulfonamides - pharmacology Thiophenes - administration & dosage Thiophenes - pharmacology Tomography Treatment Outcome Visual acuity Visual Acuity - drug effects Visual effects Visual perception |
| title | Efficacy of carbonic anhydrase inhibitors in management of cystoid macular edema in retinitis pigmentosa: A meta-analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T03%3A02%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Efficacy%20of%20carbonic%20anhydrase%20inhibitors%20in%20management%20of%20cystoid%20macular%20edema%20in%20retinitis%20pigmentosa:%20A%20meta-analysis&rft.jtitle=PloS%20one&rft.au=Huang,%20Qinzhu&rft.date=2017-10-12&rft.volume=12&rft.issue=10&rft.spage=e0186180&rft.epage=e0186180&rft.pages=e0186180-e0186180&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0186180&rft_dat=%3Cgale_plos_%3EA509259900%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1950407729&rft_id=info:pmid/29023491&rft_galeid=A509259900&rft_doaj_id=oai_doaj_org_article_c5faa42f07d74d5ebf4bf93c1cee0c0a&rfr_iscdi=true |