Functional inactivation of EBV-specific T-lymphocytes in nasopharyngeal carcinoma: implications for tumor immunotherapy

Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV) associated malignancy with high prevalence in Southern Chinese. In order to assess whether defects of EBV-specific immunity may contribute to the tumor, the phenotype and function of circulating T-cells and tumor infiltrating lymphocytes...

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Veröffentlicht in:	PloS one 2007-11, Vol.2 (11), p.e1122-e1122
Hauptverfasser:	Li, Jiang, Zeng, Xue-hui, Mo, Hao-yuan, Rolén, Ulrika, Gao, Yan-fang, Zhang, Xiao-shi, Chen, Qiu-yan, Zhang, Li, Zeng, Mu-sheng, Li, Man-zhi, Huang, Wen-lin, Wang, Xiao-ning, Zeng, Yi-xin, Masucci, Maria G
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Viral - blood Antigenic determinants Antigens Blood Cancer Carcinoma Carrier State CD16 antigen CD25 antigen CD3 antigen CD4 antigen CD45RA antigen Comparative analysis Cytokines Cytokines - blood Cytotoxicity Deactivation Drug therapy Epitopes Epstein-Barr virus Fc receptors Herpesvirus 4, Human - immunology Herpesvirus 4, Human - isolation & purification Histocompatibility antigen HLA HLA antigens Humans Immunity Immunoglobulins Immunology Immunology/Immune Response Immunology/Immunomodulation Immunophenotyping Immunotherapy In Situ Hybridization Inactivation Interleukin 2 Laboratories Lymphocyte Activation Lymphocytes Lymphocytes T Lymphoma Malignancy Medical research Melanoma Molecular biology Nasopharyngeal carcinoma Nasopharyngeal Neoplasms - immunology Nasopharyngeal Neoplasms - therapy Nasopharyngeal Neoplasms - virology Oncology Patients Peripheral blood Plasma Radiation therapy Stimulation T cells T-Lymphocytes - immunology Teaching hospitals Throat cancer Toxicity Tumors Urine Viral Load Virology/Immune Evasion Virology/New Therapies, including Antivirals and Immunotherapy Virology/Viruses and Cancer Viruses γ-Interferon
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