Identification of a novel modulator of thyroid hormone receptor-mediated action

Diabetes is characterized by reduced thyroid function and altered myogenesis after muscle injury. Here we identify a novel component of thyroid hormone action that is repressed in diabetic rat muscle. We have identified a gene, named DOR, abundantly expressed in insulin-sensitive tissues such as ske...

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Veröffentlicht in:	PloS one 2007-11, Vol.2 (11), p.e1183
Hauptverfasser:	Baumgartner, Bernhard G, Orpinell, Meritxell, Duran, Jordi, Ribas, Vicent, Burghardt, Hans E, Bach, Daniel, Villar, Ana Victoria, Paz, José C, González, Meritxell, Camps, Marta, Oriola, Josep, Rivera, Francisca, Palacín, Manuel, Zorzano, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animal tissues Animals Base Sequence Cell cycle Cloning Cytokines Diabetes Diabetes and Endocrinology Diabetes and Endocrinology/Thyroid Diabetes and Endocrinology/Type 2 Diabetes Diabetes mellitus Diabetis DNA Primers Fines & penalties Gene expression Genes Genetic aspects Hormones Hormones tiroides Humans Injury prevention Insulin Insulin-like growth factors Kinases Localization Metabolism Molecular Sequence Data Muscle Proteins - physiology Muscle, Skeletal - metabolism Musculoskeletal system Myocardium - metabolism Myogenesis Obesity Phosphorylation Promoters Proteins Rates (Animals de laboratori) Rats Rats as laboratory animals Rats, Zucker Receptors, Thyroid Hormone - chemistry Receptors, Thyroid Hormone - drug effects Receptors, Thyroid Hormone - genetics Receptors, Thyroid Hormone - physiology Reverse Transcriptase Polymerase Chain Reaction Rodents Skeletal muscle Thyroid Thyroid gland Thyroid hormones Thyroid Hormones - physiology Transcription Triiodothyronine Tumor necrosis factor-TNF Type 2 diabetes Weight control
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