Sp1 expression is disrupted in schizophrenia; a possible mechanism for the abnormal expression of mitochondrial complex I genes, NDUFV1 and NDUFV2

The prevailing hypothesis regards schizophrenia as a polygenic disease, in which multiple genes combine with each other and with environmental stimuli to produce the variance of its clinical symptoms. We investigated whether the ubiquitous transcription factor Sp1 is abnormally expressed in schizoph...

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Veröffentlicht in:	PloS one 2007-09, Vol.2 (9), p.e817-e817
Hauptverfasser:	Ben-Shachar, Dorit, Karry, Rachel
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Flanking Region - genetics Analysis Binding Binding sites Bipolar disorder Brain Cell Adhesion Molecules, Neuronal - genetics Cell Adhesion Molecules, Neuronal - metabolism Cell Line, Tumor Cortex (occipital) Cortex (parietal) Deoxyribonucleic acid DNA DNA binding proteins Electron transport chain Electron Transport Complex I - genetics Electron Transport Complex I - metabolism Environmental effects Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Female Gene expression Gene Expression Regulation - drug effects Gene Expression Regulation, Neoplastic - drug effects Genes Genetic aspects Genetic research Glucose Growth factors Humans Hypotheses Kinases Laboratories Lymphocytes Male Medical research Medicine Mental disorders Mental Health/Schizophrenia and Other Psychoses Middle Aged Mitochondria NADH Dehydrogenase - genetics NADH Dehydrogenase - metabolism NADH-ubiquinone oxidoreductase Neostriatum Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neuroblastoma Neuroblastoma cells Neuroblasts Occipital lobe Organ Specificity - drug effects Organ Specificity - genetics Patients Phosphorylation Plicamycin - pharmacology Prefrontal cortex Promoter Regions, Genetic - genetics Protein Binding - drug effects Protein expression Protein Subunits - genetics Protein Subunits - metabolism Proteins Psychiatry Psychobiology Reelin Protein RNA RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Schizophrenia Schizophrenia - genetics Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Sp1 protein Sp1 Transcription Factor - genetics Sp1 Transcription Factor - metabolism Stimuli Transcription (Genetics) Transcription factors Transcription, Genetic - drug effects
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