Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors

The EGFR T790M mutation confers acquired resistance to kinase inhibitors in human EGFR mutant lung adenocarcinoma, is occasionally detected before treatment, and may confer genetic susceptibility to lung cancer. To study further its role in lung tumorigenesis, we developed mice with inducible expres...

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Veröffentlicht in:	PloS one 2007-08, Vol.2 (8), p.e810-e810
Hauptverfasser:	Regales, Lucia, Balak, Marissa N, Gong, Yixuan, Politi, Katerina, Sawai, Ayana, Le, Carl, Koutcher, Jason A, Solit, David B, Rosen, Neal, Zakowski, Maureen F, Pao, William
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Animal models Animals Antineoplastic Agents - therapeutic use Benzoquinones - pharmacology Cancer therapies Cell Biology/Cell Signaling Disease Models, Animal Disease susceptibility Drug resistance Drug Resistance, Neoplasm - genetics Drug therapy Enzyme inhibitors Epidermal growth factor Epidermal growth factor receptors Fibroblasts Gene expression Genetic aspects Genetics and Genomics/Cancer Genetics Genotype Health physics Heat shock proteins HSP90 Heat-Shock Proteins - antagonists & inhibitors HSP90 Heat-Shock Proteins - metabolism Hsp90 protein Inhibitors Kinases Lactams, Macrocyclic - pharmacology Latency Lung cancer Lung diseases Lung Neoplasms - drug therapy Lung Neoplasms - genetics Mice Mice, Transgenic Mutants Mutation NMR Nuclear magnetic resonance Oncology Oncology/Lung Cancer Pathogenesis Physics Pneumocytes Protein Kinase Inhibitors - therapeutic use Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism Rodents Stem cells Transgenic animals Tumorigenesis Tumors
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