The chop gene contains an element for the positive regulation of the mitochondrial unfolded protein response

We have previously reported on the discovery of a mitochondrial specific unfolded protein response (mtUPR) in mammalian cells, in which the accumulation of unfolded protein within the mitochondrial matrix results in the transcriptional activation of nuclear genes encoding mitochondrial stress protei...

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Veröffentlicht in:	PloS one 2007-09, Vol.2 (9), p.e835-e835
Hauptverfasser:	Horibe, Tomohisa, Hoogenraad, Nicholas J
Format:	Artikel
Sprache:	eng
Schlagworte:	Activator protein 1 Aged Analysis Animals Apoptosis Base Sequence Biochemistry Biochemistry/Protein Folding Biochemistry/Transcription and Translation Cells (Biology) CHOP protein Clonal deletion Cytosol Endoplasmic reticulum Enzymes Fibroblasts Gene deletion Gene expression Gene Expression Regulation Genes Genetic aspects Growth factors Heat shock proteins Humans Identification Kinases Mammalian cells Metabolism Mice Mitochondria Mitochondria - metabolism Molecular Sequence Data Mutagenesis Nuclei Physiology Polymerase Chain Reaction Promoter Regions, Genetic Protein folding Proteins Sequence Homology, Nucleic Acid Stress Stress proteins Transcription (Genetics) Transcription activation Transcription Factor CHOP - genetics Transcription factors Trends
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