Cellular immune responses induced with dose-sparing intradermal administration of HIV vaccine to HIV-uninfected volunteers in the ANRS VAC16 trial

The objective was to compare the safety and cellular immunogenicity of intradermal versus intramuscular immunization with an HIV-lipopeptide candidate vaccine (LIPO-4) in healthy volunteers. A randomized, open-label trial with 24 weeks of follow-up was conducted in France at six HIV-vaccine trial si...

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Veröffentlicht in:	PloS one 2007-08, Vol.2 (8), p.e725
Hauptverfasser:	Launay, Odile, Durier, Christine, Desaint, Corinne, Silbermann, Benjamin, Jackson, Angela, Pialoux, Gilles, Bonnet, Bénédicte, Poizot-Martin, Isabelle, Gonzalez-Canali, Gustavo, Cuzin, Lise, Figuereido, Suzanne, Surenaud, Mathieu, Ben Hamouda, Nadine, Gahery, Hanne, Choppin, Jeannine, Salmon, Dominique, Guérin, Corinne, Bourgault Villada, Isabelle, Guillet, Jean-Gérard
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adult AIDS AIDS vaccines AIDS Vaccines - administration & dosage AIDS Vaccines - adverse effects AIDS Vaccines - immunology Amino Acid Sequence Antigenic determinants Biological response modifiers CD4 antigen CD4-Positive T-Lymphocytes - immunology CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell Proliferation Clinical trials Comparative analysis Enzyme-linked immunosorbent assay Epitopes Female HIV HIV Infections - immunology HIV Infections - prevention & control Human immunodeficiency virus Humans Immune response Immune response (cell-mediated) Immunity, Cellular - immunology Immunization Immunogenicity Immunology Infectious Diseases Infectious Diseases/HIV Infection and AIDS Inflammation Injection Injections, Intradermal Injections, Intramuscular Interferon Lipopeptides Lymphocytes Lymphocytes T Male Middle Aged Molecular Sequence Data Pain Peptides Peptides - genetics Peptides - immunology Plasmodium falciparum Randomization Safety Studies T cell receptors T cells Tetanus Tetanus toxin Vaccines Viral Proteins - genetics Viral Proteins - immunology Virology/Vaccines Young Adult
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