The N-Myc down regulated Gene1 (NDRG1) Is a Rab4a effector involved in vesicular recycling of E-cadherin

Cell to cell adhesion is mediated by adhesion molecules present on the cell surface. Downregulation of molecules that form the adhesion complex is a characteristic of metastatic cancer cells. Downregulation of the N-myc down regulated gene1 (NDRG1) increases prostate and breast metastasis. The exact...

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Veröffentlicht in:	PloS one 2007-09, Vol.2 (9), p.e844-e844
Hauptverfasser:	Kachhap, Sushant K, Faith, Dennis, Qian, David Z, Shabbeer, Shabana, Galloway, Nathan L, Pili, Roberto, Denmeade, Samuel R, DeMarzo, Angelo M, Carducci, Michael A
Format:	Artikel
Sprache:	eng
Schlagworte:	Biosynthesis Cadherins - metabolism Cancer Cancer metastasis Cell adhesion Cell adhesion & migration Cell adhesion molecules Cell Biology/Cell Adhesion Cell Biology/Membranes and Sorting Cell Cycle Proteins - genetics Cell Cycle Proteins - physiology Cell Line Cell surface Colorectal cancer Confocal microscopy E-cadherin Endosomes Gene expression Gene Knockdown Techniques Golgi apparatus Humans Hypoxia Immunohistochemistry Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - physiology Kinetics Leukemia Liver cancer Medicine Metastases Metastasis Microscopy Microscopy, Confocal Myc protein Neurological Disorders/Neuromuscular Diseases Oncology/Prostate Cancer Pancreatic cancer Phosphatase Phosphates Prostate Prostate cancer Protein binding Protein turnover Proteins rab4 GTP-Binding Proteins - physiology Recycling Tissue Array Analysis Transferrin Transferrins Tumors
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