Comprehensive benchmarking of SNV callers for highly admixed tumor data

Precision medicine attempts to individualize cancer therapy by matching tumor-specific genetic changes with effective targeted therapies. A crucial first step in this process is the reliable identification of cancer-relevant variants, which is considerably complicated by the impurity and heterogenei...

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Veröffentlicht in:	PloS one 2017-10, Vol.12 (10), p.e0186175-e0186175
Hauptverfasser:	Bohnert, Regina, Vivas, Sonia, Jansen, Gunther
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Alleles Benchmarking Biology and Life Sciences Breast cancer Cancer Cancer therapies Care and treatment Computer Simulation Databases, Genetic Datasets Evolution Exome - genetics Gene frequency Gene Frequency - genetics Genetic aspects Genomes Germ Cells - metabolism Humans Medicine Medicine and Health Sciences Mutation Neoplasms - genetics Physical Sciences Polymorphism, Single Nucleotide - genetics Precision medicine Reference Standards Reproducibility of Results Research and Analysis Methods Sensitivity Sequence Alignment Studies Tumors
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