Fine tuning of globin gene expression by DNA methylation

Expression patterns in the globin gene cluster are subject to developmental regulation in vivo. While the gamma(A) and gamma(G) genes are expressed in fetal liver, both are silenced in adult erythrocytes. In order to decipher the role of DNA methylation in this process, we generated a YAC transgenic...

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Veröffentlicht in:	PloS one 2006-12, Vol.1 (1), p.e46-e46
Hauptverfasser:	Goren, Alon, Simchen, Giora, Fibach, Eitan, Szabo, Piroska E, Tanimoto, Keiji, Chakalova, Lyubomira, Pfeifer, Gerd P, Fraser, Peter J, Engel, James D, Cedar, Howard
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Apoptosis Artificial chromosomes Base Sequence beta-Thalassemia - genetics Biochemistry Biology Cell division Chromatin Chromosomes, Artificial, Yeast - genetics Deoxyribonucleic acid DNA DNA binding proteins DNA damage DNA Methylation DNA Primers - genetics Erythroblasts - metabolism Erythrocytes Erythroid cells Fetal Hemoglobin - genetics Fetuses Fibroblasts gamma-Globins - genetics Gene Expression Genes Genetic engineering Genetics Hemoglobin Hemoglobins Histones - chemistry Histones - metabolism Humans In vivo methods and tests Laboratories Liver Methylation Mice Mice, Transgenic Molecular Biology/Chromatin Structure Molecular Biology/DNA Methylation Molecular Biology/Histone Modification Patients Promoter Regions, Genetic Protein Binding Proteins Rodents Transcription (Genetics) Transcription factors Transgenic animals Transgenic mice Tuning
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