HIV/Human herpesvirus co-infections: Impact on tryptophan-kynurenine pathway and immune reconstitution
Co-infections with human herpesvirus (HHV) have been associated with residual chronic inflammation in antiretroviral (ART)-treated human immunodeficiency virus (HIV)-infected individuals. However, the role of HHV in modulating the tryptophan-kynurenine pathway and clinical outcomes in HIV-infected i...
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| creator | Yap, Siew Hwei Abdullah, Noor Kamila McStea, Megan Takayama, Kozo Chong, Meng Li Crisci, Elisa Larsson, Marie Azwa, Iskandar Kamarulzaman, Adeeba Leong, Kok Hoong Woo, Yin Ling Rajasuriar, Reena |
| description | Co-infections with human herpesvirus (HHV) have been associated with residual chronic inflammation in antiretroviral (ART)-treated human immunodeficiency virus (HIV)-infected individuals. However, the role of HHV in modulating the tryptophan-kynurenine pathway and clinical outcomes in HIV-infected individuals is poorly understood. Thus, we investigated the seroprevalence of four common HHVs among treated HIV-infected participants and their impact on kynurenine/tryptophan (K/T) ratio and long-term CD4 T-cell recovery in HIV/HHV co-infected participants.
In this cross-sectional study, HIV-infected participants receiving suppressive ART for a minimum of 12 months were recruited from the University Malaya Medical Centre (UMMC), Malaysia. Stored plasma was analyzed for CMV, VZV, HSV-1 and HSV-2 IgG antibody levels, immune activation markers (interleukin-6, interferon-γ, neopterin and sCD14), kynurenine and tryptophan concentrations. The influence of the number of HHV co-infection and K/T ratio on CD4 T-cell recovery was assessed using multivariate Poisson regression.
A total of 232 HIV-infected participants were recruited and all participants were seropositive for at least one HHV; 96.1% with CMV, 86.6% with VZV, 70.7% with HSV-1 and 53.9% with HSV-2. K/T ratio had a significant positive correlation with CMV (rho = 0.205, p = 0.002), VZV (rho = 0.173, p = 0.009) and a tendency with HSV-2 (rho = 0.120, p = 0.070), with CMV antibody titer demonstrating the strongest modulating effect on K/T ratio among the four HHVs assessed in SOM analysis. In multivariate analysis, higher K/T ratio (p = 0.03) and increasing number of HHV co-infections (p |
| doi_str_mv | 10.1371/journal.pone.0186000 |
| format | Article |
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In this cross-sectional study, HIV-infected participants receiving suppressive ART for a minimum of 12 months were recruited from the University Malaya Medical Centre (UMMC), Malaysia. Stored plasma was analyzed for CMV, VZV, HSV-1 and HSV-2 IgG antibody levels, immune activation markers (interleukin-6, interferon-γ, neopterin and sCD14), kynurenine and tryptophan concentrations. The influence of the number of HHV co-infection and K/T ratio on CD4 T-cell recovery was assessed using multivariate Poisson regression.
A total of 232 HIV-infected participants were recruited and all participants were seropositive for at least one HHV; 96.1% with CMV, 86.6% with VZV, 70.7% with HSV-1 and 53.9% with HSV-2. K/T ratio had a significant positive correlation with CMV (rho = 0.205, p = 0.002), VZV (rho = 0.173, p = 0.009) and a tendency with HSV-2 (rho = 0.120, p = 0.070), with CMV antibody titer demonstrating the strongest modulating effect on K/T ratio among the four HHVs assessed in SOM analysis. In multivariate analysis, higher K/T ratio (p = 0.03) and increasing number of HHV co-infections (p<0.001) were independently associated with poorer CD4 T-cell recovery following 12 months of ART initiation.
Multiple HHV co-infections are common among ART-treated HIV-infected participants in the developing country setting and associated with persistent immune activation and poorer CD4 T-cell recovery.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0186000</identifier><identifier>PMID: 29016635</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acquired immune deficiency syndrome ; Activation ; Adult ; AIDS ; Antibodies, Viral - blood ; Antiretroviral agents ; Antiretroviral drugs ; Antiretroviral Therapy, Highly Active ; Biology and Life Sciences ; Care and treatment ; CD4 antigen ; CD4-Positive T-Lymphocytes - immunology ; Coinfection - blood ; Coinfection - epidemiology ; Coinfection - immunology ; Coinfection - virology ; Cytomegalovirus ; Developing countries ; Dosage and administration ; Female ; Health aspects ; Health care facilities ; Herpes Simplex - blood ; Herpes Simplex - epidemiology ; Herpes Simplex - immunology ; Herpes Simplex - virology ; Herpesvirus 1, Human - isolation & purification ; Herpesvirus 1, Human - pathogenicity ; Herpesvirus infections ; HIV ; HIV Infections - blood ; HIV Infections - epidemiology ; HIV Infections - immunology ; HIV Infections - virology ; Human immunodeficiency virus ; Humans ; IgG antibody ; Immune reconstitution ; Immune Reconstitution Inflammatory Syndrome - blood ; Immune Reconstitution Inflammatory Syndrome - immunology ; Immune Reconstitution Inflammatory Syndrome - metabolism ; Immune Reconstitution Inflammatory Syndrome - virology ; Immune response ; Immunoglobulin G ; Infections ; Inflammation - blood ; Inflammation - epidemiology ; Inflammation - immunology ; Inflammation - virology ; Interferon ; Interleukin 6 ; Kynurenine - metabolism ; LDCs ; Lymphocytes T ; Male ; Medicine and Health Sciences ; Metabolic Networks and Pathways ; Mortality ; Multivariate analysis ; Neopterin ; Physical Sciences ; Poisson density functions ; Prevention ; Recovery ; Regression analysis ; Seroepidemiologic Studies ; Serology ; Statistical analysis ; Tryptophan ; Tryptophan - metabolism ; Viruses</subject><ispartof>PloS one, 2017-10, Vol.12 (10), p.e0186000-e0186000</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Yap et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Yap et al 2017 Yap et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c730t-33b07de2f58abf9eae0c8ea7d3dbf14c44126692e2e145c165394c64c9e92ae43</citedby><cites>FETCH-LOGICAL-c730t-33b07de2f58abf9eae0c8ea7d3dbf14c44126692e2e145c165394c64c9e92ae43</cites><orcidid>0000-0003-3756-0629</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633182/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633182/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29016635$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-142149$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Yap, Siew Hwei</creatorcontrib><creatorcontrib>Abdullah, Noor Kamila</creatorcontrib><creatorcontrib>McStea, Megan</creatorcontrib><creatorcontrib>Takayama, Kozo</creatorcontrib><creatorcontrib>Chong, Meng Li</creatorcontrib><creatorcontrib>Crisci, Elisa</creatorcontrib><creatorcontrib>Larsson, Marie</creatorcontrib><creatorcontrib>Azwa, Iskandar</creatorcontrib><creatorcontrib>Kamarulzaman, Adeeba</creatorcontrib><creatorcontrib>Leong, Kok Hoong</creatorcontrib><creatorcontrib>Woo, Yin Ling</creatorcontrib><creatorcontrib>Rajasuriar, Reena</creatorcontrib><title>HIV/Human herpesvirus co-infections: Impact on tryptophan-kynurenine pathway and immune reconstitution</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Co-infections with human herpesvirus (HHV) have been associated with residual chronic inflammation in antiretroviral (ART)-treated human immunodeficiency virus (HIV)-infected individuals. However, the role of HHV in modulating the tryptophan-kynurenine pathway and clinical outcomes in HIV-infected individuals is poorly understood. Thus, we investigated the seroprevalence of four common HHVs among treated HIV-infected participants and their impact on kynurenine/tryptophan (K/T) ratio and long-term CD4 T-cell recovery in HIV/HHV co-infected participants.
In this cross-sectional study, HIV-infected participants receiving suppressive ART for a minimum of 12 months were recruited from the University Malaya Medical Centre (UMMC), Malaysia. Stored plasma was analyzed for CMV, VZV, HSV-1 and HSV-2 IgG antibody levels, immune activation markers (interleukin-6, interferon-γ, neopterin and sCD14), kynurenine and tryptophan concentrations. The influence of the number of HHV co-infection and K/T ratio on CD4 T-cell recovery was assessed using multivariate Poisson regression.
A total of 232 HIV-infected participants were recruited and all participants were seropositive for at least one HHV; 96.1% with CMV, 86.6% with VZV, 70.7% with HSV-1 and 53.9% with HSV-2. K/T ratio had a significant positive correlation with CMV (rho = 0.205, p = 0.002), VZV (rho = 0.173, p = 0.009) and a tendency with HSV-2 (rho = 0.120, p = 0.070), with CMV antibody titer demonstrating the strongest modulating effect on K/T ratio among the four HHVs assessed in SOM analysis. In multivariate analysis, higher K/T ratio (p = 0.03) and increasing number of HHV co-infections (p<0.001) were independently associated with poorer CD4 T-cell recovery following 12 months of ART initiation.
Multiple HHV co-infections are common among ART-treated HIV-infected participants in the developing country setting and associated with persistent immune activation and poorer CD4 T-cell recovery.</description><subject>Acquired immune deficiency syndrome</subject><subject>Activation</subject><subject>Adult</subject><subject>AIDS</subject><subject>Antibodies, Viral - blood</subject><subject>Antiretroviral agents</subject><subject>Antiretroviral drugs</subject><subject>Antiretroviral Therapy, Highly Active</subject><subject>Biology and Life Sciences</subject><subject>Care and treatment</subject><subject>CD4 antigen</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>Coinfection - blood</subject><subject>Coinfection - epidemiology</subject><subject>Coinfection - immunology</subject><subject>Coinfection - virology</subject><subject>Cytomegalovirus</subject><subject>Developing countries</subject><subject>Dosage and administration</subject><subject>Female</subject><subject>Health aspects</subject><subject>Health care facilities</subject><subject>Herpes Simplex - blood</subject><subject>Herpes Simplex - epidemiology</subject><subject>Herpes Simplex - immunology</subject><subject>Herpes Simplex - virology</subject><subject>Herpesvirus 1, Human - isolation & purification</subject><subject>Herpesvirus 1, Human - pathogenicity</subject><subject>Herpesvirus infections</subject><subject>HIV</subject><subject>HIV Infections - blood</subject><subject>HIV Infections - epidemiology</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - virology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>IgG antibody</subject><subject>Immune reconstitution</subject><subject>Immune Reconstitution Inflammatory Syndrome - blood</subject><subject>Immune Reconstitution Inflammatory Syndrome - immunology</subject><subject>Immune Reconstitution Inflammatory Syndrome - metabolism</subject><subject>Immune Reconstitution Inflammatory Syndrome - virology</subject><subject>Immune response</subject><subject>Immunoglobulin G</subject><subject>Infections</subject><subject>Inflammation - blood</subject><subject>Inflammation - epidemiology</subject><subject>Inflammation - immunology</subject><subject>Inflammation - virology</subject><subject>Interferon</subject><subject>Interleukin 6</subject><subject>Kynurenine - metabolism</subject><subject>LDCs</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Metabolic Networks and Pathways</subject><subject>Mortality</subject><subject>Multivariate analysis</subject><subject>Neopterin</subject><subject>Physical Sciences</subject><subject>Poisson density functions</subject><subject>Prevention</subject><subject>Recovery</subject><subject>Regression analysis</subject><subject>Seroepidemiologic Studies</subject><subject>Serology</subject><subject>Statistical analysis</subject><subject>Tryptophan</subject><subject>Tryptophan - metabolism</subject><subject>Viruses</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>D8T</sourceid><sourceid>DOA</sourceid><recordid>eNqNk0tv1DAUhSMEoqXwDxBEQkKwyNSOHSdmgTQqj45UqRKPbi3HuZlxSexgOy3z73E606pBXaAsEt1859g-1zdJXmK0wKTEx5d2dEZ2i8EaWCBcMYTQo-QQc5JnLEfk8b3vg-SZ95cIFaRi7GlykHOEGSPFYdKeri6OT8demnQDbgB_pd3oU2UzbVpQQVvjP6SrfpAqpNakwW2HYIeNNNmvrRkdGG0gHWTYXMttKk2T6r4fY8mBitKgwzh5PE-etLLz8GL_Pkp-fvn84-Q0Ozv_ujpZnmWqJChkhNSobCBvi0rWLQcJSFUgy4Y0dYupohTnjPEccsC0UJgVhFPFqOLAcwmUHCWvd75DZ73YR-QF5pQjlud8IlY7orHyUgxO99JthZVa3BSsWwvpglYdiKKpWIyVK9y0VClStYTmtCkBKlrXPI9e2c7LX8Mw1jO3T_pieePW6VFgmmPKI_9xv7ux7qFRYIKT3Uw2_2P0RqztlSgYIbiaFny3N3D29wg-iF57BV0nDdhxOmcRbwIuURnRN_-gD6exp9YyHji23MZ11WQqlgWqyopQXERq8QAVnwZ6HdsMrY71meD9TBCZAH_CWo7ei9X3b__Pnl_M2bf32A3ILmy87W6umJ-DdAcqZ7130N6FjJGYxuc2DTGNj9iPT5S9ut-gO9HtvJC_zpUWug</recordid><startdate>20171009</startdate><enddate>20171009</enddate><creator>Yap, Siew Hwei</creator><creator>Abdullah, Noor Kamila</creator><creator>McStea, Megan</creator><creator>Takayama, Kozo</creator><creator>Chong, Meng Li</creator><creator>Crisci, Elisa</creator><creator>Larsson, Marie</creator><creator>Azwa, Iskandar</creator><creator>Kamarulzaman, Adeeba</creator><creator>Leong, Kok Hoong</creator><creator>Woo, Yin Ling</creator><creator>Rajasuriar, Reena</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>ABXSW</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>DG8</scope><scope>ZZAVC</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-3756-0629</orcidid></search><sort><creationdate>20171009</creationdate><title>HIV/Human herpesvirus co-infections: Impact on tryptophan-kynurenine pathway and immune reconstitution</title><author>Yap, Siew Hwei ; Abdullah, Noor Kamila ; McStea, Megan ; Takayama, Kozo ; Chong, Meng Li ; Crisci, Elisa ; Larsson, Marie ; Azwa, Iskandar ; Kamarulzaman, Adeeba ; Leong, Kok Hoong ; Woo, Yin Ling ; Rajasuriar, Reena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c730t-33b07de2f58abf9eae0c8ea7d3dbf14c44126692e2e145c165394c64c9e92ae43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Activation</topic><topic>Adult</topic><topic>AIDS</topic><topic>Antibodies, Viral - blood</topic><topic>Antiretroviral agents</topic><topic>Antiretroviral drugs</topic><topic>Antiretroviral Therapy, Highly Active</topic><topic>Biology and Life Sciences</topic><topic>Care and treatment</topic><topic>CD4 antigen</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>Coinfection - blood</topic><topic>Coinfection - epidemiology</topic><topic>Coinfection - immunology</topic><topic>Coinfection - virology</topic><topic>Cytomegalovirus</topic><topic>Developing countries</topic><topic>Dosage and administration</topic><topic>Female</topic><topic>Health aspects</topic><topic>Health care facilities</topic><topic>Herpes Simplex - blood</topic><topic>Herpes Simplex - epidemiology</topic><topic>Herpes Simplex - immunology</topic><topic>Herpes Simplex - virology</topic><topic>Herpesvirus 1, Human - isolation & purification</topic><topic>Herpesvirus 1, Human - pathogenicity</topic><topic>Herpesvirus infections</topic><topic>HIV</topic><topic>HIV Infections - blood</topic><topic>HIV Infections - epidemiology</topic><topic>HIV Infections - immunology</topic><topic>HIV Infections - virology</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>IgG antibody</topic><topic>Immune reconstitution</topic><topic>Immune Reconstitution Inflammatory Syndrome - blood</topic><topic>Immune Reconstitution Inflammatory Syndrome - immunology</topic><topic>Immune Reconstitution Inflammatory Syndrome - metabolism</topic><topic>Immune Reconstitution Inflammatory Syndrome - virology</topic><topic>Immune response</topic><topic>Immunoglobulin G</topic><topic>Infections</topic><topic>Inflammation - blood</topic><topic>Inflammation - epidemiology</topic><topic>Inflammation - immunology</topic><topic>Inflammation - virology</topic><topic>Interferon</topic><topic>Interleukin 6</topic><topic>Kynurenine - metabolism</topic><topic>LDCs</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>Medicine and Health Sciences</topic><topic>Metabolic Networks and Pathways</topic><topic>Mortality</topic><topic>Multivariate analysis</topic><topic>Neopterin</topic><topic>Physical Sciences</topic><topic>Poisson density functions</topic><topic>Prevention</topic><topic>Recovery</topic><topic>Regression analysis</topic><topic>Seroepidemiologic Studies</topic><topic>Serology</topic><topic>Statistical analysis</topic><topic>Tryptophan</topic><topic>Tryptophan - metabolism</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yap, Siew Hwei</creatorcontrib><creatorcontrib>Abdullah, Noor Kamila</creatorcontrib><creatorcontrib>McStea, Megan</creatorcontrib><creatorcontrib>Takayama, Kozo</creatorcontrib><creatorcontrib>Chong, Meng Li</creatorcontrib><creatorcontrib>Crisci, Elisa</creatorcontrib><creatorcontrib>Larsson, Marie</creatorcontrib><creatorcontrib>Azwa, Iskandar</creatorcontrib><creatorcontrib>Kamarulzaman, Adeeba</creatorcontrib><creatorcontrib>Leong, Kok Hoong</creatorcontrib><creatorcontrib>Woo, Yin Ling</creatorcontrib><creatorcontrib>Rajasuriar, Reena</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SWEPUB Linköpings universitet full text</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Linköpings universitet</collection><collection>SwePub Articles full text</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yap, Siew Hwei</au><au>Abdullah, Noor Kamila</au><au>McStea, Megan</au><au>Takayama, Kozo</au><au>Chong, Meng Li</au><au>Crisci, Elisa</au><au>Larsson, Marie</au><au>Azwa, Iskandar</au><au>Kamarulzaman, Adeeba</au><au>Leong, Kok Hoong</au><au>Woo, Yin Ling</au><au>Rajasuriar, Reena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HIV/Human herpesvirus co-infections: Impact on tryptophan-kynurenine pathway and immune reconstitution</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-10-09</date><risdate>2017</risdate><volume>12</volume><issue>10</issue><spage>e0186000</spage><epage>e0186000</epage><pages>e0186000-e0186000</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Co-infections with human herpesvirus (HHV) have been associated with residual chronic inflammation in antiretroviral (ART)-treated human immunodeficiency virus (HIV)-infected individuals. However, the role of HHV in modulating the tryptophan-kynurenine pathway and clinical outcomes in HIV-infected individuals is poorly understood. Thus, we investigated the seroprevalence of four common HHVs among treated HIV-infected participants and their impact on kynurenine/tryptophan (K/T) ratio and long-term CD4 T-cell recovery in HIV/HHV co-infected participants.
In this cross-sectional study, HIV-infected participants receiving suppressive ART for a minimum of 12 months were recruited from the University Malaya Medical Centre (UMMC), Malaysia. Stored plasma was analyzed for CMV, VZV, HSV-1 and HSV-2 IgG antibody levels, immune activation markers (interleukin-6, interferon-γ, neopterin and sCD14), kynurenine and tryptophan concentrations. The influence of the number of HHV co-infection and K/T ratio on CD4 T-cell recovery was assessed using multivariate Poisson regression.
A total of 232 HIV-infected participants were recruited and all participants were seropositive for at least one HHV; 96.1% with CMV, 86.6% with VZV, 70.7% with HSV-1 and 53.9% with HSV-2. K/T ratio had a significant positive correlation with CMV (rho = 0.205, p = 0.002), VZV (rho = 0.173, p = 0.009) and a tendency with HSV-2 (rho = 0.120, p = 0.070), with CMV antibody titer demonstrating the strongest modulating effect on K/T ratio among the four HHVs assessed in SOM analysis. In multivariate analysis, higher K/T ratio (p = 0.03) and increasing number of HHV co-infections (p<0.001) were independently associated with poorer CD4 T-cell recovery following 12 months of ART initiation.
Multiple HHV co-infections are common among ART-treated HIV-infected participants in the developing country setting and associated with persistent immune activation and poorer CD4 T-cell recovery.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29016635</pmid><doi>10.1371/journal.pone.0186000</doi><orcidid>https://orcid.org/0000-0003-3756-0629</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2017-10, Vol.12 (10), p.e0186000-e0186000 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1949062294 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SWEPUB Freely available online; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Acquired immune deficiency syndrome Activation Adult AIDS Antibodies, Viral - blood Antiretroviral agents Antiretroviral drugs Antiretroviral Therapy, Highly Active Biology and Life Sciences Care and treatment CD4 antigen CD4-Positive T-Lymphocytes - immunology Coinfection - blood Coinfection - epidemiology Coinfection - immunology Coinfection - virology Cytomegalovirus Developing countries Dosage and administration Female Health aspects Health care facilities Herpes Simplex - blood Herpes Simplex - epidemiology Herpes Simplex - immunology Herpes Simplex - virology Herpesvirus 1, Human - isolation & purification Herpesvirus 1, Human - pathogenicity Herpesvirus infections HIV HIV Infections - blood HIV Infections - epidemiology HIV Infections - immunology HIV Infections - virology Human immunodeficiency virus Humans IgG antibody Immune reconstitution Immune Reconstitution Inflammatory Syndrome - blood Immune Reconstitution Inflammatory Syndrome - immunology Immune Reconstitution Inflammatory Syndrome - metabolism Immune Reconstitution Inflammatory Syndrome - virology Immune response Immunoglobulin G Infections Inflammation - blood Inflammation - epidemiology Inflammation - immunology Inflammation - virology Interferon Interleukin 6 Kynurenine - metabolism LDCs Lymphocytes T Male Medicine and Health Sciences Metabolic Networks and Pathways Mortality Multivariate analysis Neopterin Physical Sciences Poisson density functions Prevention Recovery Regression analysis Seroepidemiologic Studies Serology Statistical analysis Tryptophan Tryptophan - metabolism Viruses |
| title | HIV/Human herpesvirus co-infections: Impact on tryptophan-kynurenine pathway and immune reconstitution |
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