Genetic determinants of serum 25-hydroxyvitamin D concentration during pregnancy and type 1 diabetes in the child
The in utero environment plays an important role in shaping development and later life health of the fetus. It has been shown that maternal genetic factors in the metabolic pathway of vitamin D associate with type 1 diabetes in the child. In this study we analyzed the genetic determinants of serum 2...
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| creator | Miettinen, Maija E Smart, Melissa C Kinnunen, Leena Harjutsalo, Valma Reinert-Hartwall, Linnea Ylivinkka, Irene Surcel, Heljä-Marja Lamberg-Allardt, Christel Hitman, Graham A Tuomilehto, Jaakko |
| description | The in utero environment plays an important role in shaping development and later life health of the fetus. It has been shown that maternal genetic factors in the metabolic pathway of vitamin D associate with type 1 diabetes in the child. In this study we analyzed the genetic determinants of serum 25-hydroxyvitamin D (25OHD) concentration during pregnancy in mothers whose children later developed type 1 diabetes and in control mothers.
474 mothers of type 1 diabetic children and 348 mothers of non-diabetic children were included in the study. We previously selected 7 single nucleotide polymorphisms (SNPs) in four genes in the metabolic pathway of vitamin D vitamin based on our previously published data demonstrating an association between genotype and serum 25OHD concentration. In this re-analysis, possible differences in strength in the association between the SNPs and serum 25OHD concentration in mothers of type 1 diabetic and non-diabetic children were investigated. Serum 25OHD concentrations were previously shown to be similar between the mothers of type 1 diabetic and non-diabetic children and vitamin D deficiency prevalent in both groups.
Associations between serum 25OHD concentration and 2 SNPs, one in the vitamin D receptor (VDR) gene (rs4516035) and one in the group-specific component (GC) gene (rs12512631), were stronger during pregnancy in mothers whose children later developed type 1 diabetes than in mothers whose children did not (pinteraction = 0.03, 0.02, respectively).
We show for the first time that there are differences in the strength of genetic determinants of serum 25OHD concentration during pregnancy between the mothers of type 1 diabetic and non-diabetic children. Our results emphasize that the in utero environment including maternal vitamin D metabolism should be important lines of investigation when searching for factors that lead to early programming of type 1 diabetes. |
| doi_str_mv | 10.1371/journal.pone.0184942 |
| format | Article |
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474 mothers of type 1 diabetic children and 348 mothers of non-diabetic children were included in the study. We previously selected 7 single nucleotide polymorphisms (SNPs) in four genes in the metabolic pathway of vitamin D vitamin based on our previously published data demonstrating an association between genotype and serum 25OHD concentration. In this re-analysis, possible differences in strength in the association between the SNPs and serum 25OHD concentration in mothers of type 1 diabetic and non-diabetic children were investigated. Serum 25OHD concentrations were previously shown to be similar between the mothers of type 1 diabetic and non-diabetic children and vitamin D deficiency prevalent in both groups.
Associations between serum 25OHD concentration and 2 SNPs, one in the vitamin D receptor (VDR) gene (rs4516035) and one in the group-specific component (GC) gene (rs12512631), were stronger during pregnancy in mothers whose children later developed type 1 diabetes than in mothers whose children did not (pinteraction = 0.03, 0.02, respectively).
We show for the first time that there are differences in the strength of genetic determinants of serum 25OHD concentration during pregnancy between the mothers of type 1 diabetic and non-diabetic children. Our results emphasize that the in utero environment including maternal vitamin D metabolism should be important lines of investigation when searching for factors that lead to early programming of type 1 diabetes.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0184942</identifier><identifier>PMID: 28976992</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>25-Hydroxyvitamin D ; Adult ; Biology and Life Sciences ; Case-Control Studies ; Child ; Children ; Chronic illnesses ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - genetics ; Disease prevention ; Female ; Fetuses ; Genetic factors ; Health risk assessment ; Humans ; Medicine and Health Sciences ; Metabolism ; Physical sciences ; Polymorphism, Single Nucleotide ; Pregnancy ; Single-nucleotide polymorphism ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D receptors ; Vitamin deficiency</subject><ispartof>PloS one, 2017-10, Vol.12 (10), p.e0184942-e0184942</ispartof><rights>2017 Miettinen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Miettinen et al 2017 Miettinen et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c592t-f5cba13df63ca3a18561e4b611e68597833a32e444bf90c2a4e9cd69680791333</citedby><cites>FETCH-LOGICAL-c592t-f5cba13df63ca3a18561e4b611e68597833a32e444bf90c2a4e9cd69680791333</cites><orcidid>0000-0002-5587-7227</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627909/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627909/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2104,2930,23873,27931,27932,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28976992$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Zmijewski, Michal</contributor><creatorcontrib>Miettinen, Maija E</creatorcontrib><creatorcontrib>Smart, Melissa C</creatorcontrib><creatorcontrib>Kinnunen, Leena</creatorcontrib><creatorcontrib>Harjutsalo, Valma</creatorcontrib><creatorcontrib>Reinert-Hartwall, Linnea</creatorcontrib><creatorcontrib>Ylivinkka, Irene</creatorcontrib><creatorcontrib>Surcel, Heljä-Marja</creatorcontrib><creatorcontrib>Lamberg-Allardt, Christel</creatorcontrib><creatorcontrib>Hitman, Graham A</creatorcontrib><creatorcontrib>Tuomilehto, Jaakko</creatorcontrib><title>Genetic determinants of serum 25-hydroxyvitamin D concentration during pregnancy and type 1 diabetes in the child</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The in utero environment plays an important role in shaping development and later life health of the fetus. It has been shown that maternal genetic factors in the metabolic pathway of vitamin D associate with type 1 diabetes in the child. In this study we analyzed the genetic determinants of serum 25-hydroxyvitamin D (25OHD) concentration during pregnancy in mothers whose children later developed type 1 diabetes and in control mothers.
474 mothers of type 1 diabetic children and 348 mothers of non-diabetic children were included in the study. We previously selected 7 single nucleotide polymorphisms (SNPs) in four genes in the metabolic pathway of vitamin D vitamin based on our previously published data demonstrating an association between genotype and serum 25OHD concentration. In this re-analysis, possible differences in strength in the association between the SNPs and serum 25OHD concentration in mothers of type 1 diabetic and non-diabetic children were investigated. Serum 25OHD concentrations were previously shown to be similar between the mothers of type 1 diabetic and non-diabetic children and vitamin D deficiency prevalent in both groups.
Associations between serum 25OHD concentration and 2 SNPs, one in the vitamin D receptor (VDR) gene (rs4516035) and one in the group-specific component (GC) gene (rs12512631), were stronger during pregnancy in mothers whose children later developed type 1 diabetes than in mothers whose children did not (pinteraction = 0.03, 0.02, respectively).
We show for the first time that there are differences in the strength of genetic determinants of serum 25OHD concentration during pregnancy between the mothers of type 1 diabetic and non-diabetic children. Our results emphasize that the in utero environment including maternal vitamin D metabolism should be important lines of investigation when searching for factors that lead to early programming of type 1 diabetes.</description><subject>25-Hydroxyvitamin D</subject><subject>Adult</subject><subject>Biology and Life Sciences</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Children</subject><subject>Chronic illnesses</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - genetics</subject><subject>Disease prevention</subject><subject>Female</subject><subject>Fetuses</subject><subject>Genetic factors</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Medicine and Health Sciences</subject><subject>Metabolism</subject><subject>Physical sciences</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Pregnancy</subject><subject>Single-nucleotide polymorphism</subject><subject>Vitamin D</subject><subject>Vitamin D - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miettinen, Maija E</au><au>Smart, Melissa C</au><au>Kinnunen, Leena</au><au>Harjutsalo, Valma</au><au>Reinert-Hartwall, Linnea</au><au>Ylivinkka, Irene</au><au>Surcel, Heljä-Marja</au><au>Lamberg-Allardt, Christel</au><au>Hitman, Graham A</au><au>Tuomilehto, Jaakko</au><au>Zmijewski, Michal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic determinants of serum 25-hydroxyvitamin D concentration during pregnancy and type 1 diabetes in the child</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-10-04</date><risdate>2017</risdate><volume>12</volume><issue>10</issue><spage>e0184942</spage><epage>e0184942</epage><pages>e0184942-e0184942</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The in utero environment plays an important role in shaping development and later life health of the fetus. It has been shown that maternal genetic factors in the metabolic pathway of vitamin D associate with type 1 diabetes in the child. In this study we analyzed the genetic determinants of serum 25-hydroxyvitamin D (25OHD) concentration during pregnancy in mothers whose children later developed type 1 diabetes and in control mothers.
474 mothers of type 1 diabetic children and 348 mothers of non-diabetic children were included in the study. We previously selected 7 single nucleotide polymorphisms (SNPs) in four genes in the metabolic pathway of vitamin D vitamin based on our previously published data demonstrating an association between genotype and serum 25OHD concentration. In this re-analysis, possible differences in strength in the association between the SNPs and serum 25OHD concentration in mothers of type 1 diabetic and non-diabetic children were investigated. Serum 25OHD concentrations were previously shown to be similar between the mothers of type 1 diabetic and non-diabetic children and vitamin D deficiency prevalent in both groups.
Associations between serum 25OHD concentration and 2 SNPs, one in the vitamin D receptor (VDR) gene (rs4516035) and one in the group-specific component (GC) gene (rs12512631), were stronger during pregnancy in mothers whose children later developed type 1 diabetes than in mothers whose children did not (pinteraction = 0.03, 0.02, respectively).
We show for the first time that there are differences in the strength of genetic determinants of serum 25OHD concentration during pregnancy between the mothers of type 1 diabetic and non-diabetic children. Our results emphasize that the in utero environment including maternal vitamin D metabolism should be important lines of investigation when searching for factors that lead to early programming of type 1 diabetes.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28976992</pmid><doi>10.1371/journal.pone.0184942</doi><orcidid>https://orcid.org/0000-0002-5587-7227</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 25-Hydroxyvitamin D Adult Biology and Life Sciences Case-Control Studies Child Children Chronic illnesses Diabetes Diabetes mellitus Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - genetics Disease prevention Female Fetuses Genetic factors Health risk assessment Humans Medicine and Health Sciences Metabolism Physical sciences Polymorphism, Single Nucleotide Pregnancy Single-nucleotide polymorphism Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D receptors Vitamin deficiency |
| title | Genetic determinants of serum 25-hydroxyvitamin D concentration during pregnancy and type 1 diabetes in the child |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-03T23%3A38%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genetic%20determinants%20of%20serum%2025-hydroxyvitamin%20D%20concentration%20during%20pregnancy%20and%20type%201%20diabetes%20in%20the%20child&rft.jtitle=PloS%20one&rft.au=Miettinen,%20Maija%20E&rft.date=2017-10-04&rft.volume=12&rft.issue=10&rft.spage=e0184942&rft.epage=e0184942&rft.pages=e0184942-e0184942&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0184942&rft_dat=%3Cproquest_plos_%3E1947620289%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1947046270&rft_id=info:pmid/28976992&rft_doaj_id=oai_doaj_org_article_d0d7ee4f7d6840e3ad44c7febeaa4bc0&rfr_iscdi=true |