Effects of meal composition and meal timing on the expression of genes involved in hepatic drug metabolism in rats

With chronotherapy, drug administration is synchronized with daily rhythms in drug clearance and pharmacokinetics. Daily rhythms in gene expression are centrally mastered by the suprachiasmatic nucleus of the hypothalamus as well as by tissue clocks containing similar molecular mechanisms in periphe...

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Veröffentlicht in:	PloS one 2017-10, Vol.12 (10), p.e0185520-e0185520
Hauptverfasser:	de Vries, E M, Oosterman, J E, Eggink, H M, de Goede, P, Sen, S, Foppen, E, Boudzovitch-Surovtseva, O, Boelen, A, Romijn, J A, laFleur, S E, Kalsbeek, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Feed Animals Biology and Life Sciences Chronotherapy Circadian Rhythm Clocks Composition effects Cytochrome Cytochrome P-450 Enzyme System - metabolism Diet Diurnal Drug metabolism Endocrinology Enzymes Feeding Feeding Behavior Food Gene Expression Genes High fat diet Hypothalamus Light Liver Liver - metabolism Male Materials selection Meals Medicine and Health Sciences Metabolism Molecular modelling Neurosciences Nuclear receptors Obesity Organs Pharmaceutical Preparations - metabolism Pharmacokinetics Pharmacology Physiological aspects Rats Rats, Wistar Real-Time Polymerase Chain Reaction Receptors Rhythm Rodents Sugar Suprachiasmatic nucleus Time measurement
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