Evaluation of hemostasis parameters and the role of the oxidative damage to plasma proteins in the modulation of hemostasis in patients with nephrolithiasis before and after extracorporeal shock wave lithotripsy
Extracorporeal shock wave lithotripsy (ESWL) is a commonly-used method in urology, which may modulate hemostasis and may induce lipid peroxidation in patients with nephrolithiasis. However, previous studies only examine changes occurring in patients 30-240 min after ESWL. The main aim of the present...
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| description | Extracorporeal shock wave lithotripsy (ESWL) is a commonly-used method in urology, which may modulate hemostasis and may induce lipid peroxidation in patients with nephrolithiasis. However, previous studies only examine changes occurring in patients 30-240 min after ESWL. The main aim of the present study was to determine whether oxidative stress may modulate the hemostatic activity of plasma in patients with nephrolithiasis before ESWL and the day after treatment ESWL. This will be performed by measuring selected parameters of hemostasis in these patients, both before ESWL and the following day, and assessing the level of oxidative damage to plasma proteins in these patients by measuring two biomarkers.
Twelve patients with nephrolithiasis and 10 healthy participants were included. The following parameters of hemostasis were measured: the activated partial thromboplastin time (APTT), prothrombin time (PT), and thrombin time (TT) of plasma, the level of fibrinogen, the level of D-dimer and blood platelet count. In addition, two selected biomarkers of oxidative stress were measured: protein carbonylation level and the number of protein thiol groups.
No difference was observed between patients with nephrolithiasis before and after ESWL and healthy controls with regard to PT, TT or APTT. Fibrinogen concentration and blood platelet count were lower in the nephrolithiasis patients in the period after ESWL than before ESWL. The nephrolithiasis patients demonstrated elevated D-dimer concentration after ESWL. However, although oxidative damage was observed in the plasma proteins in the nephrolithiasis patients, this was not influenced by ESWL.
Oxidative stress may induce changes of hemostasis in patients with nephrolithiasis, both before and after ESWL. In addition, changes of hemostasis parameters such as fibrinogen, blood platelet count and D-dimer level can be observed in these patients, especially after ESWL, and this may suggest that ESWL modulates hemostasis. By having a better understanding of the influence of ESWL on hemostasis, this could lead to modifying patient care for those patients at increased risk of bleeding. |
| doi_str_mv | 10.1371/journal.pone.0185157 |
| format | Article |
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Twelve patients with nephrolithiasis and 10 healthy participants were included. The following parameters of hemostasis were measured: the activated partial thromboplastin time (APTT), prothrombin time (PT), and thrombin time (TT) of plasma, the level of fibrinogen, the level of D-dimer and blood platelet count. In addition, two selected biomarkers of oxidative stress were measured: protein carbonylation level and the number of protein thiol groups.
No difference was observed between patients with nephrolithiasis before and after ESWL and healthy controls with regard to PT, TT or APTT. Fibrinogen concentration and blood platelet count were lower in the nephrolithiasis patients in the period after ESWL than before ESWL. The nephrolithiasis patients demonstrated elevated D-dimer concentration after ESWL. However, although oxidative damage was observed in the plasma proteins in the nephrolithiasis patients, this was not influenced by ESWL.
Oxidative stress may induce changes of hemostasis in patients with nephrolithiasis, both before and after ESWL. In addition, changes of hemostasis parameters such as fibrinogen, blood platelet count and D-dimer level can be observed in these patients, especially after ESWL, and this may suggest that ESWL modulates hemostasis. By having a better understanding of the influence of ESWL on hemostasis, this could lead to modifying patient care for those patients at increased risk of bleeding.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0185157</identifier><identifier>PMID: 28968428</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Antioxidants ; Biochemistry ; Biology and Life Sciences ; Biomarkers ; Bleeding ; Blood ; Blood levels ; Blood platelets ; Blood Proteins - metabolism ; Carbonyls ; Care and treatment ; Chronic illnesses ; Damage assessment ; Diagnosis ; Endangered & extinct species ; Environmental protection ; Extracorporeal shockwave lithotripsy ; Family medical history ; Female ; Fibrinogen ; Hemorrhage ; Hemostasis ; Hemostatics ; Humans ; Kidney Calculi - metabolism ; Kidney Calculi - physiopathology ; Kidney Calculi - therapy ; Kidney stones ; Lipid peroxidation ; Lithotripsy ; Lithotripsy - methods ; Male ; Measurement methods ; Medicine and Health Sciences ; Mens health ; Middle Aged ; Nephrolithiasis ; Oxidative Stress ; Patients ; Peroxidation ; Physical Sciences ; Physiological aspects ; Plasma proteins ; Plasmas (physics) ; Platelets ; Proteins ; Prothrombin ; Risk factors ; Shock waves ; Thrombin ; Thromboplastin ; Urology ; Womens health</subject><ispartof>PloS one, 2017-10, Vol.12 (10), p.e0185157-e0185157</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Woźniak et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Woźniak et al 2017 Woźniak et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-549966209cf70b7b148eb96c36a1556e616954227b09b505d09c42ef8caa43bb3</citedby><cites>FETCH-LOGICAL-c692t-549966209cf70b7b148eb96c36a1556e616954227b09b505d09c42ef8caa43bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624585/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624585/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28968428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Khodarahmi, Reza</contributor><creatorcontrib>Woźniak, Paweł</creatorcontrib><creatorcontrib>Kontek, Bogdan</creatorcontrib><creatorcontrib>Różański, Waldemar</creatorcontrib><creatorcontrib>Olas, Beata</creatorcontrib><title>Evaluation of hemostasis parameters and the role of the oxidative damage to plasma proteins in the modulation of hemostasis in patients with nephrolithiasis before and after extracorporeal shock wave lithotripsy</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Extracorporeal shock wave lithotripsy (ESWL) is a commonly-used method in urology, which may modulate hemostasis and may induce lipid peroxidation in patients with nephrolithiasis. However, previous studies only examine changes occurring in patients 30-240 min after ESWL. The main aim of the present study was to determine whether oxidative stress may modulate the hemostatic activity of plasma in patients with nephrolithiasis before ESWL and the day after treatment ESWL. This will be performed by measuring selected parameters of hemostasis in these patients, both before ESWL and the following day, and assessing the level of oxidative damage to plasma proteins in these patients by measuring two biomarkers.
Twelve patients with nephrolithiasis and 10 healthy participants were included. The following parameters of hemostasis were measured: the activated partial thromboplastin time (APTT), prothrombin time (PT), and thrombin time (TT) of plasma, the level of fibrinogen, the level of D-dimer and blood platelet count. In addition, two selected biomarkers of oxidative stress were measured: protein carbonylation level and the number of protein thiol groups.
No difference was observed between patients with nephrolithiasis before and after ESWL and healthy controls with regard to PT, TT or APTT. Fibrinogen concentration and blood platelet count were lower in the nephrolithiasis patients in the period after ESWL than before ESWL. The nephrolithiasis patients demonstrated elevated D-dimer concentration after ESWL. However, although oxidative damage was observed in the plasma proteins in the nephrolithiasis patients, this was not influenced by ESWL.
Oxidative stress may induce changes of hemostasis in patients with nephrolithiasis, both before and after ESWL. In addition, changes of hemostasis parameters such as fibrinogen, blood platelet count and D-dimer level can be observed in these patients, especially after ESWL, and this may suggest that ESWL modulates hemostasis. By having a better understanding of the influence of ESWL on hemostasis, this could lead to modifying patient care for those patients at increased risk of bleeding.</description><subject>Antioxidants</subject><subject>Biochemistry</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Bleeding</subject><subject>Blood</subject><subject>Blood levels</subject><subject>Blood platelets</subject><subject>Blood Proteins - metabolism</subject><subject>Carbonyls</subject><subject>Care and treatment</subject><subject>Chronic illnesses</subject><subject>Damage assessment</subject><subject>Diagnosis</subject><subject>Endangered & extinct species</subject><subject>Environmental protection</subject><subject>Extracorporeal shockwave lithotripsy</subject><subject>Family medical history</subject><subject>Female</subject><subject>Fibrinogen</subject><subject>Hemorrhage</subject><subject>Hemostasis</subject><subject>Hemostatics</subject><subject>Humans</subject><subject>Kidney Calculi - metabolism</subject><subject>Kidney Calculi - physiopathology</subject><subject>Kidney Calculi - therapy</subject><subject>Kidney stones</subject><subject>Lipid peroxidation</subject><subject>Lithotripsy</subject><subject>Lithotripsy - methods</subject><subject>Male</subject><subject>Measurement methods</subject><subject>Medicine and Health Sciences</subject><subject>Mens health</subject><subject>Middle Aged</subject><subject>Nephrolithiasis</subject><subject>Oxidative Stress</subject><subject>Patients</subject><subject>Peroxidation</subject><subject>Physical Sciences</subject><subject>Physiological aspects</subject><subject>Plasma proteins</subject><subject>Plasmas (physics)</subject><subject>Platelets</subject><subject>Proteins</subject><subject>Prothrombin</subject><subject>Risk factors</subject><subject>Shock waves</subject><subject>Thrombin</subject><subject>Thromboplastin</subject><subject>Urology</subject><subject>Womens health</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9tu1DAQhiMEoqXwBggsISG42MVObMe-QaqqAitVqsTp1pokzsbFiYPt9PCcvBDOdlvtol6gXMQaf_PPeA5Z9pLgJSlK8uHCTX4AuxzdoJeYCEZY-Sg7JLLIFzzHxeOd80H2LIQLjFkhOH-aHeRCckFzcZj9Ob0EO0E0bkCuRZ3uXYgQTEAjeOh11D4gGBoUO428s3qm5rO7Nk1yu9SogR7WGkWHRguhBzR6F7UZAjLDBu1dM9mHQqT7Mdn1EAO6MrFDgx67FCQdzQaodOu83sSHNqWC9HX0UDs_JjNYFDpX_0JXkLKYnVz0Zgw3z7MnLdigX2z_R9mPT6ffT74szs4_r06OzxY1l3lcMColT9WRdVviqqwIFbqSvC44EMa45oRLRvO8rLCsGGZNImmuW1ED0KKqiqPs9a3uaF1Q234ERSRlZS4FyxOxuiUaBxdq9KYHf6McGLUxOL9W4KOprVaUVS2QBue04JRiVrGGVCWUpRRUyHbW-riNNlW9bupUNQ92T3T_ZjCdWrtLxXhOmWBJ4N1WwLvfkw5R9SbU2loYtJs2eXNaYJHP6Jt_0Idft6XWkB5ghtbNzZlF1THDZUlFSj5Ryweo9DW6N3Ua3tYk-57D-z2HxMTU9zVMIajVt6__z57_3Gff7rBdmp_YBWeneTDDPkhvwdq7ELxu74tMsJp3764aat49td295PZqt0H3TnfLVvwF3gYu9Q</recordid><startdate>20171002</startdate><enddate>20171002</enddate><creator>Woźniak, Paweł</creator><creator>Kontek, Bogdan</creator><creator>Różański, Waldemar</creator><creator>Olas, Beata</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20171002</creationdate><title>Evaluation of hemostasis parameters and the role of the oxidative damage to plasma proteins in the modulation of hemostasis in patients with nephrolithiasis before and after extracorporeal shock wave lithotripsy</title><author>Woźniak, Paweł ; Kontek, Bogdan ; Różański, Waldemar ; Olas, Beata</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-549966209cf70b7b148eb96c36a1556e616954227b09b505d09c42ef8caa43bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Antioxidants</topic><topic>Biochemistry</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers</topic><topic>Bleeding</topic><topic>Blood</topic><topic>Blood levels</topic><topic>Blood platelets</topic><topic>Blood Proteins - metabolism</topic><topic>Carbonyls</topic><topic>Care and treatment</topic><topic>Chronic illnesses</topic><topic>Damage assessment</topic><topic>Diagnosis</topic><topic>Endangered & extinct species</topic><topic>Environmental protection</topic><topic>Extracorporeal shockwave lithotripsy</topic><topic>Family medical history</topic><topic>Female</topic><topic>Fibrinogen</topic><topic>Hemorrhage</topic><topic>Hemostasis</topic><topic>Hemostatics</topic><topic>Humans</topic><topic>Kidney Calculi - metabolism</topic><topic>Kidney Calculi - physiopathology</topic><topic>Kidney Calculi - therapy</topic><topic>Kidney stones</topic><topic>Lipid peroxidation</topic><topic>Lithotripsy</topic><topic>Lithotripsy - methods</topic><topic>Male</topic><topic>Measurement methods</topic><topic>Medicine and Health Sciences</topic><topic>Mens health</topic><topic>Middle Aged</topic><topic>Nephrolithiasis</topic><topic>Oxidative Stress</topic><topic>Patients</topic><topic>Peroxidation</topic><topic>Physical Sciences</topic><topic>Physiological aspects</topic><topic>Plasma proteins</topic><topic>Plasmas (physics)</topic><topic>Platelets</topic><topic>Proteins</topic><topic>Prothrombin</topic><topic>Risk factors</topic><topic>Shock waves</topic><topic>Thrombin</topic><topic>Thromboplastin</topic><topic>Urology</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Woźniak, Paweł</creatorcontrib><creatorcontrib>Kontek, Bogdan</creatorcontrib><creatorcontrib>Różański, Waldemar</creatorcontrib><creatorcontrib>Olas, Beata</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale in Context : Opposing Viewpoints</collection><collection>Gale in Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Database (Proquest)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Databases</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Woźniak, Paweł</au><au>Kontek, Bogdan</au><au>Różański, Waldemar</au><au>Olas, Beata</au><au>Khodarahmi, Reza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of hemostasis parameters and the role of the oxidative damage to plasma proteins in the modulation of hemostasis in patients with nephrolithiasis before and after extracorporeal shock wave lithotripsy</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-10-02</date><risdate>2017</risdate><volume>12</volume><issue>10</issue><spage>e0185157</spage><epage>e0185157</epage><pages>e0185157-e0185157</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Extracorporeal shock wave lithotripsy (ESWL) is a commonly-used method in urology, which may modulate hemostasis and may induce lipid peroxidation in patients with nephrolithiasis. However, previous studies only examine changes occurring in patients 30-240 min after ESWL. The main aim of the present study was to determine whether oxidative stress may modulate the hemostatic activity of plasma in patients with nephrolithiasis before ESWL and the day after treatment ESWL. This will be performed by measuring selected parameters of hemostasis in these patients, both before ESWL and the following day, and assessing the level of oxidative damage to plasma proteins in these patients by measuring two biomarkers.
Twelve patients with nephrolithiasis and 10 healthy participants were included. The following parameters of hemostasis were measured: the activated partial thromboplastin time (APTT), prothrombin time (PT), and thrombin time (TT) of plasma, the level of fibrinogen, the level of D-dimer and blood platelet count. In addition, two selected biomarkers of oxidative stress were measured: protein carbonylation level and the number of protein thiol groups.
No difference was observed between patients with nephrolithiasis before and after ESWL and healthy controls with regard to PT, TT or APTT. Fibrinogen concentration and blood platelet count were lower in the nephrolithiasis patients in the period after ESWL than before ESWL. The nephrolithiasis patients demonstrated elevated D-dimer concentration after ESWL. However, although oxidative damage was observed in the plasma proteins in the nephrolithiasis patients, this was not influenced by ESWL.
Oxidative stress may induce changes of hemostasis in patients with nephrolithiasis, both before and after ESWL. In addition, changes of hemostasis parameters such as fibrinogen, blood platelet count and D-dimer level can be observed in these patients, especially after ESWL, and this may suggest that ESWL modulates hemostasis. By having a better understanding of the influence of ESWL on hemostasis, this could lead to modifying patient care for those patients at increased risk of bleeding.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28968428</pmid><doi>10.1371/journal.pone.0185157</doi><tpages>e0185157</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2017-10, Vol.12 (10), p.e0185157-e0185157 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1945729852 |
| source | PubMed (Medline); PLoS; MEDLINE; DOAJ Directory of Open Access Journals; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library |
| subjects | Antioxidants Biochemistry Biology and Life Sciences Biomarkers Bleeding Blood Blood levels Blood platelets Blood Proteins - metabolism Carbonyls Care and treatment Chronic illnesses Damage assessment Diagnosis Endangered & extinct species Environmental protection Extracorporeal shockwave lithotripsy Family medical history Female Fibrinogen Hemorrhage Hemostasis Hemostatics Humans Kidney Calculi - metabolism Kidney Calculi - physiopathology Kidney Calculi - therapy Kidney stones Lipid peroxidation Lithotripsy Lithotripsy - methods Male Measurement methods Medicine and Health Sciences Mens health Middle Aged Nephrolithiasis Oxidative Stress Patients Peroxidation Physical Sciences Physiological aspects Plasma proteins Plasmas (physics) Platelets Proteins Prothrombin Risk factors Shock waves Thrombin Thromboplastin Urology Womens health |
| title | Evaluation of hemostasis parameters and the role of the oxidative damage to plasma proteins in the modulation of hemostasis in patients with nephrolithiasis before and after extracorporeal shock wave lithotripsy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T18%3A36%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20of%20hemostasis%20parameters%20and%20the%20role%20of%20the%20oxidative%20damage%20to%20plasma%20proteins%20in%20the%20modulation%20of%20hemostasis%20in%20patients%20with%20nephrolithiasis%20before%20and%20after%20extracorporeal%20shock%20wave%20lithotripsy&rft.jtitle=PloS%20one&rft.au=Wo%C5%BAniak,%20Pawe%C5%82&rft.date=2017-10-02&rft.volume=12&rft.issue=10&rft.spage=e0185157&rft.epage=e0185157&rft.pages=e0185157-e0185157&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0185157&rft_dat=%3Cgale_plos_%3EA507748798%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1945729852&rft_id=info:pmid/28968428&rft_galeid=A507748798&rft_doaj_id=oai_doaj_org_article_45bfa1d024364405b5d1b7a7798489f2&rfr_iscdi=true |