Intranasal post-cardiac arrest treatment with orexin-A facilitates arousal from coma and ameliorates neuroinflammation

Cardiac arrest (CA) entails significant risks of coma resulting in poor neurological and behavioral outcomes after resuscitation. Significant subsequent morbidity and mortality in post-CA patients are largely due to the cerebral and cardiac dysfunction that accompanies prolonged whole-body ischemia...

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Veröffentlicht in:	PloS one 2017-09, Vol.12 (9), p.e0182707-e0182707
Hauptverfasser:	Modi, Hiren R, Wang, Qihong, Gd, Sahithi, Sherman, David, Greenwald, Elliot, Savonenko, Alena V, Geocadin, Romergryko G, Thakor, Nitish V
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animals Arousal Arousal - drug effects Behavior, Animal - drug effects Biology and Life Sciences Biomarkers - metabolism Biomedical engineering Brain Brain - drug effects Brain - pathology Brain - physiopathology Cardiac arrest CD11b antigen Cerebral blood flow Cognitive ability Coma Coma - complications Coma - drug therapy Coma - physiopathology Complications and side effects Cytokines Dosage and administration Drug therapy EEG Electroencephalography Engineering Gamma Rhythm - drug effects Genetic aspects Glial fibrillary acidic protein Health aspects Heart Arrest - physiopathology Heart diseases Hemodynamics - drug effects Hypothalamus Hypothermia Inflammation Inflammation - complications Inflammation - drug therapy Inflammation - pathology Interleukin 1 Ischemia Male Markers Medical research Medicine Medicine and Health Sciences Morbidity mRNA Neurons Neuroprotection Neurosciences Nitric-oxide synthase Orexin receptor antagonists Orexin receptors Orexin Receptors - genetics Orexin Receptors - metabolism Orexins Orexins - administration & dosage Orexins - pharmacology Orexins - therapeutic use Prefrontal cortex Rats, Wistar Receptors Recovery Research and Analysis Methods Resuscitation Risk taking RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Singers Sleep Sodium Chloride - administration & dosage Sodium Chloride - pharmacology Studies Treatment Outcome Tumor necrosis factor Tumor necrosis factor-TNF
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