Low-intensity pulsed ultrasound enhances angiogenesis and ameliorates contractile dysfunction of pressure-overloaded heart in mice

Chronic left ventricular (LV) pressure overload causes relative ischemia with resultant LV dysfunction. We have recently demonstrated that low-intensity pulsed ultrasound (LIPUS) improves myocardial ischemia in a pig model of chronic myocardial ischemia through enhanced myocardial angiogenesis. In t...

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Veröffentlicht in:	PloS one 2017-09, Vol.12 (9), p.e0185555-e0185555
Hauptverfasser:	Ogata, Tsuyoshi, Ito, Kenta, Shindo, Tomohiko, Hatanaka, Kazuaki, Eguchi, Kumiko, Kurosawa, Ryo, Kagaya, Yuta, Monma, Yuto, Ichijo, Sadamitsu, Taki, Hirofumi, Kanai, Hiroshi, Shimokawa, Hiroaki
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Angiogenesis Animals Aorta Biology and Life Sciences Biomedical engineering Blotting, Western Cardiovascular disease Care and treatment Collagen (type III) Complications and side effects Coronary vessels Diagnosis Engineering schools Experiments Fibrosis Flow velocity Heart Heart - physiopathology Heart attacks Heart diseases Heart failure Hypertension Hypoxia Ischemia Laboratory animals Medicine Medicine and Health Sciences Mice Mice, Inbred C57BL Mortality mRNA Muscle contraction Myocardial Contraction Myocardial ischemia Neovascularization Neovascularization, Pathologic Nitric oxide Physiological aspects Pressure Real-Time Polymerase Chain Reaction Research and Analysis Methods Rodents Signal Transduction Surgery Therapy Ultrasonic imaging Ultrasonics Ultrasound University graduates Vascular endothelial growth factor Ventricle Ventricular Dysfunction, Left - physiopathology
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