Association of MTTP gene variants with pediatric NAFLD: A candidate-gene-based analysis of single nucleotide variations in obese children

We used targeted next-generation sequencing to investigate whether genetic variants of lipid metabolism-related genes are associated with increased susceptibility to nonalcoholic fatty liver disease (NAFLD) in obese children. A cohort of 100 obese children aged 6 to 18 years were divided into NAFLD...

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Veröffentlicht in:	PloS one 2017-09, Vol.12 (9), p.e0185396-e0185396
Hauptverfasser:	Dai, Dongling, Wen, Feiqiu, Zhou, Shaoming, Su, Zhe, Liu, Guosheng, Wang, Mingbang, Zhou, Jianli, He, Fusheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Anthropometry Apolipoproteins Biochemical markers Biology and Life Sciences Carrier Proteins - genetics Child Childhood obesity Children Children & youth Cholesterol Cohort Studies Complications and side effects Disruption Fasting Fatty liver Female Gene expression Gene sequencing Genes Genetic aspects Genetic diversity Genetic variation Hepatocytes Hepatology Hospitals Humans Insulin resistance Laboratories Lipid metabolism Lipids Liver Liver diseases Male Medical research Medicine and Health Sciences Mental depression Metabolism Mutation NMR Non-alcoholic Fatty Liver Disease - complications Non-alcoholic Fatty Liver Disease - genetics Nuclear magnetic resonance Obesity Obesity - complications Obesity - genetics Pediatrics People and places Physiological aspects Polymorphism, Single Nucleotide Proteins Regression analysis Risk factors Secretion Single-nucleotide polymorphism Studies Ultrasonic imaging Ultrasound
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