Incidence and clinical features of the incidentally found vascular stump thrombus during routine follow up after oncologic lung surgery
We aimed to evaluate the incidence and clinical features of vascular stump thrombus after oncologic lung surgery. A retrospective analysis of records from our institutional database dated between 2009 and 2016 was performed. Data regarding demographics, clinical presentation, medication use, operati...
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| creator | Moon, Mi Hyoung Beck, Kyongmin Sarah Moon, Young Kyu Park, Jae Kil Sung, Sook Whan |
| description | We aimed to evaluate the incidence and clinical features of vascular stump thrombus after oncologic lung surgery.
A retrospective analysis of records from our institutional database dated between 2009 and 2016 was performed. Data regarding demographics, clinical presentation, medication use, operative findings, pathology, and radiologic findings were retrieved.
The study cohort consisted of 648 oncologic surgeries for primary lung cancer. The incidence of thrombus in the entire population was 5.7% (37/648). Most thrombi were incidentally found on follow-up chest computed tomography scans. Univariate Cox proportional hazard analysis showed that age (p = 0.02), adjuvant therapy (p |
| doi_str_mv | 10.1371/journal.pone.0185140 |
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A retrospective analysis of records from our institutional database dated between 2009 and 2016 was performed. Data regarding demographics, clinical presentation, medication use, operative findings, pathology, and radiologic findings were retrieved.
The study cohort consisted of 648 oncologic surgeries for primary lung cancer. The incidence of thrombus in the entire population was 5.7% (37/648). Most thrombi were incidentally found on follow-up chest computed tomography scans. Univariate Cox proportional hazard analysis showed that age (p = 0.02), adjuvant therapy (p <0.001), neoadjuvant therapy (p = 0.04), left-sided surgery (p = 0.02), complex surgery greater than simple lobectomy or segmentectomy (p <0.001), advanced stages (p <0.001), non-adenocarcinoma (p = 0.003), and thoracotomy approach (p = 0.009) were associated with an increased risk of vascular stump thrombus. There were no embolic events in our cohort, except for a case of pulmonary thromboembolism. During follow-up, 43.2% (16/37) of thrombi had completely resolved, 48.6% (18/37) showed partial regression and stabilization, and 8.1% (3/37) had progressed.
The incidence of vascular stump thrombus in our study was not negligible. The clinical course of stump thrombus appears to be benign in most cases. Anticoagulation may be used with caution based on an individual basis depending on each patient's risk factors.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0185140</identifier><identifier>PMID: 28953945</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adenocarcinoma ; Aged ; Anticoagulants ; Biology and Life Sciences ; Blood clots ; Cardiovascular disease ; Care and treatment ; Cohort Studies ; Complications and side effects ; Computed tomography ; Demographics ; Demography ; Drugs ; Embolisms ; Female ; Follow-Up Studies ; Hazard assessment ; Heart surgery ; Hospitals ; Humans ; Incidence ; Incidental Findings ; Lung cancer ; Lung diseases ; Lung Neoplasms - blood supply ; Lung Neoplasms - surgery ; Lung surgery ; Male ; Medical imaging ; Medical records ; Medicine and Health Sciences ; Middle Aged ; Patient outcomes ; Patients ; Pulmonary arteries ; Regression analysis ; Research and Analysis Methods ; Retrospective Studies ; Risk analysis ; Risk Factors ; Surgery ; Therapy ; Thoracic surgery ; Thromboembolism ; Thrombosis ; Thrombosis - complications ; Thrombosis - diagnosis ; Thrombosis - diagnostic imaging ; Tomography ; Tomography, X-Ray Computed ; Veins & arteries</subject><ispartof>PloS one, 2017-09, Vol.12 (9), p.e0185140-e0185140</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Moon et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Moon et al 2017 Moon et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-7574d7afa33d97e50c751579a1c16c79f06e5bf3556156b433feed1e856e3cf3</citedby><cites>FETCH-LOGICAL-c758t-7574d7afa33d97e50c751579a1c16c79f06e5bf3556156b433feed1e856e3cf3</cites><orcidid>0000-0002-8480-0915</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617172/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617172/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28953945$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moon, Mi Hyoung</creatorcontrib><creatorcontrib>Beck, Kyongmin Sarah</creatorcontrib><creatorcontrib>Moon, Young Kyu</creatorcontrib><creatorcontrib>Park, Jae Kil</creatorcontrib><creatorcontrib>Sung, Sook Whan</creatorcontrib><title>Incidence and clinical features of the incidentally found vascular stump thrombus during routine follow up after oncologic lung surgery</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>We aimed to evaluate the incidence and clinical features of vascular stump thrombus after oncologic lung surgery.
A retrospective analysis of records from our institutional database dated between 2009 and 2016 was performed. Data regarding demographics, clinical presentation, medication use, operative findings, pathology, and radiologic findings were retrieved.
The study cohort consisted of 648 oncologic surgeries for primary lung cancer. The incidence of thrombus in the entire population was 5.7% (37/648). Most thrombi were incidentally found on follow-up chest computed tomography scans. Univariate Cox proportional hazard analysis showed that age (p = 0.02), adjuvant therapy (p <0.001), neoadjuvant therapy (p = 0.04), left-sided surgery (p = 0.02), complex surgery greater than simple lobectomy or segmentectomy (p <0.001), advanced stages (p <0.001), non-adenocarcinoma (p = 0.003), and thoracotomy approach (p = 0.009) were associated with an increased risk of vascular stump thrombus. There were no embolic events in our cohort, except for a case of pulmonary thromboembolism. During follow-up, 43.2% (16/37) of thrombi had completely resolved, 48.6% (18/37) showed partial regression and stabilization, and 8.1% (3/37) had progressed.
The incidence of vascular stump thrombus in our study was not negligible. The clinical course of stump thrombus appears to be benign in most cases. Anticoagulation may be used with caution based on an individual basis depending on each patient's risk factors.</description><subject>Adenocarcinoma</subject><subject>Aged</subject><subject>Anticoagulants</subject><subject>Biology and Life Sciences</subject><subject>Blood clots</subject><subject>Cardiovascular disease</subject><subject>Care and treatment</subject><subject>Cohort Studies</subject><subject>Complications and side effects</subject><subject>Computed tomography</subject><subject>Demographics</subject><subject>Demography</subject><subject>Drugs</subject><subject>Embolisms</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Hazard assessment</subject><subject>Heart surgery</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Incidence</subject><subject>Incidental Findings</subject><subject>Lung cancer</subject><subject>Lung diseases</subject><subject>Lung Neoplasms - blood supply</subject><subject>Lung Neoplasms - surgery</subject><subject>Lung surgery</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical records</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Pulmonary arteries</subject><subject>Regression analysis</subject><subject>Research and Analysis Methods</subject><subject>Retrospective Studies</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Surgery</subject><subject>Therapy</subject><subject>Thoracic surgery</subject><subject>Thromboembolism</subject><subject>Thrombosis</subject><subject>Thrombosis - complications</subject><subject>Thrombosis - diagnosis</subject><subject>Thrombosis - diagnostic imaging</subject><subject>Tomography</subject><subject>Tomography, X-Ray Computed</subject><subject>Veins & arteries</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk99qFDEUxgdRbK2-gWhAEL3YNZlMMjM3Qin-WSgUtHgbspmT2SzZZE0m1X0CX9tsd1p2pBeSi4ST3_lO8iWnKF4SPCe0Jh_WPgUn7XzrHcwxaRip8KPilLS0nPES08dH65PiWYxrjBltOH9anJRNy2hbsdPiz8Ip04FTgKTrkLLGGSUt0iCHFCAir9GwAmQO2CCt3SHtU2ZvZFTJyoDikDbbTAW_WaaIuhSM61HwaTAOMmyt_4XSFkk9QEDeKW99bxSyKWMxhR7C7nnxREsb4cU4nxXXnz9dX3ydXV59WVycX85UzZphVrO66mqpJaVdWwPDOUxY3UqiCFd1qzEHttSUMU4YX1aUaoCOQMM4UKXpWfH6ILu1PorRwihIW1FOGkpwJhYHovNyLbbBbGTYCS-NuA340AsZBqMsCMUo7nDDJWnLqqHlUuK2xtC0QCtN-F7r41gtLTfQqexfkHYiOt1xZiV6fyPy6WtSl1ng3SgQ_M8EcRAbExVYKx34dHvuqqIt5VVG3_yDPny7keplvoBx2ue6ai8qzhnmTZ1d3pedP0Dl0cHGqPzftMnxScL7SUJmBvg99DLFKBbfv_0_e_Vjyr49Ylcg7bCK3uaP5V2cgtUBVMHHGEDfm0yw2LfLnRti3y5ibJec9ur4ge6T7vqD_gW5tBHG</recordid><startdate>20170927</startdate><enddate>20170927</enddate><creator>Moon, Mi Hyoung</creator><creator>Beck, Kyongmin Sarah</creator><creator>Moon, Young Kyu</creator><creator>Park, Jae Kil</creator><creator>Sung, Sook Whan</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-8480-0915</orcidid></search><sort><creationdate>20170927</creationdate><title>Incidence and clinical features of the incidentally found vascular stump thrombus during routine follow up after oncologic lung surgery</title><author>Moon, Mi Hyoung ; Beck, Kyongmin Sarah ; Moon, Young Kyu ; Park, Jae Kil ; Sung, Sook Whan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-7574d7afa33d97e50c751579a1c16c79f06e5bf3556156b433feed1e856e3cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adenocarcinoma</topic><topic>Aged</topic><topic>Anticoagulants</topic><topic>Biology and Life Sciences</topic><topic>Blood clots</topic><topic>Cardiovascular disease</topic><topic>Care and treatment</topic><topic>Cohort Studies</topic><topic>Complications and side effects</topic><topic>Computed tomography</topic><topic>Demographics</topic><topic>Demography</topic><topic>Drugs</topic><topic>Embolisms</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Hazard assessment</topic><topic>Heart surgery</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Incidence</topic><topic>Incidental Findings</topic><topic>Lung cancer</topic><topic>Lung diseases</topic><topic>Lung Neoplasms - blood supply</topic><topic>Lung Neoplasms - surgery</topic><topic>Lung surgery</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medical records</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Pulmonary arteries</topic><topic>Regression analysis</topic><topic>Research and Analysis Methods</topic><topic>Retrospective Studies</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Surgery</topic><topic>Therapy</topic><topic>Thoracic surgery</topic><topic>Thromboembolism</topic><topic>Thrombosis</topic><topic>Thrombosis - complications</topic><topic>Thrombosis - diagnosis</topic><topic>Thrombosis - diagnostic imaging</topic><topic>Tomography</topic><topic>Tomography, X-Ray Computed</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moon, Mi Hyoung</creatorcontrib><creatorcontrib>Beck, Kyongmin Sarah</creatorcontrib><creatorcontrib>Moon, Young Kyu</creatorcontrib><creatorcontrib>Park, Jae Kil</creatorcontrib><creatorcontrib>Sung, Sook Whan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moon, Mi Hyoung</au><au>Beck, Kyongmin Sarah</au><au>Moon, Young Kyu</au><au>Park, Jae Kil</au><au>Sung, Sook Whan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence and clinical features of the incidentally found vascular stump thrombus during routine follow up after oncologic lung surgery</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-09-27</date><risdate>2017</risdate><volume>12</volume><issue>9</issue><spage>e0185140</spage><epage>e0185140</epage><pages>e0185140-e0185140</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>We aimed to evaluate the incidence and clinical features of vascular stump thrombus after oncologic lung surgery.
A retrospective analysis of records from our institutional database dated between 2009 and 2016 was performed. Data regarding demographics, clinical presentation, medication use, operative findings, pathology, and radiologic findings were retrieved.
The study cohort consisted of 648 oncologic surgeries for primary lung cancer. The incidence of thrombus in the entire population was 5.7% (37/648). Most thrombi were incidentally found on follow-up chest computed tomography scans. Univariate Cox proportional hazard analysis showed that age (p = 0.02), adjuvant therapy (p <0.001), neoadjuvant therapy (p = 0.04), left-sided surgery (p = 0.02), complex surgery greater than simple lobectomy or segmentectomy (p <0.001), advanced stages (p <0.001), non-adenocarcinoma (p = 0.003), and thoracotomy approach (p = 0.009) were associated with an increased risk of vascular stump thrombus. There were no embolic events in our cohort, except for a case of pulmonary thromboembolism. During follow-up, 43.2% (16/37) of thrombi had completely resolved, 48.6% (18/37) showed partial regression and stabilization, and 8.1% (3/37) had progressed.
The incidence of vascular stump thrombus in our study was not negligible. The clinical course of stump thrombus appears to be benign in most cases. Anticoagulation may be used with caution based on an individual basis depending on each patient's risk factors.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28953945</pmid><doi>10.1371/journal.pone.0185140</doi><tpages>e0185140</tpages><orcidid>https://orcid.org/0000-0002-8480-0915</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma Aged Anticoagulants Biology and Life Sciences Blood clots Cardiovascular disease Care and treatment Cohort Studies Complications and side effects Computed tomography Demographics Demography Drugs Embolisms Female Follow-Up Studies Hazard assessment Heart surgery Hospitals Humans Incidence Incidental Findings Lung cancer Lung diseases Lung Neoplasms - blood supply Lung Neoplasms - surgery Lung surgery Male Medical imaging Medical records Medicine and Health Sciences Middle Aged Patient outcomes Patients Pulmonary arteries Regression analysis Research and Analysis Methods Retrospective Studies Risk analysis Risk Factors Surgery Therapy Thoracic surgery Thromboembolism Thrombosis Thrombosis - complications Thrombosis - diagnosis Thrombosis - diagnostic imaging Tomography Tomography, X-Ray Computed Veins & arteries |
| title | Incidence and clinical features of the incidentally found vascular stump thrombus during routine follow up after oncologic lung surgery |
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