Sanger and Next-Generation Sequencing data for characterization of CTL epitopes in archived HIV-1 proviral DNA

One of the strategies for curing viral HIV-1 is a therapeutic vaccine involving the stimulation of cytotoxic CD8-positive T cells (CTL) that are Human Leucocyte Antigen (HLA)-restricted. The lack of efficiency of previous vaccination strategies may have been due to the immunogenic peptides used, whi...

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Veröffentlicht in:	PloS one 2017-09, Vol.12 (9), p.e0185211-e0185211
Hauptverfasser:	Tumiotto, Camille, Riviere, Lionel, Bellecave, Pantxika, Recordon-Pinson, Patricia, Vilain-Parce, Alice, Guidicelli, Gwenda-Line, Fleury, Hervé
Format:	Artikel
Sprache:	eng
Schlagworte:	Alignment Alleles Amino Acid Sequence Analysis Antigenic determinants Antigens Automation Biology and life sciences CD8 antigen CD8-Positive T-Lymphocytes - immunology Correlation analysis Cytotoxicity Data management Deoxyribonucleic acid DNA DNA sequencing DNA, Viral - genetics Drug resistance Drug therapy Epitopes Epitopes, T-Lymphocyte - chemistry Epitopes, T-Lymphocyte - immunology Gene sequencing Genetic aspects Genomics Health aspects High-Throughput Nucleotide Sequencing Histocompatibility antigen HLA HIV HIV patients HIV-1 - genetics HIV-1 - immunology Human immunodeficiency virus Humans Immunogenicity Life sciences Lymphocytes Lymphocytes T Major histocompatibility complex Medicine and Health Sciences Mutation Nucleotide sequence Patients Peptides Proteins Research and analysis methods Sequence Analysis, DNA Software T cells Tissue typing Vaccination Vaccines Viruses
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