Estradiol impairs the antiproliferative and proapoptotic effect of Zoledronic acid in hormone sensitive breast cancer cells in vitro

Zoledronic acid (ZA) has antiresorptive effects and protects from bone metastasis in women with early breast cancer. In addition, in postmenopausal women with endocrine responsive breast cancer ZA prolongs DFS. The exact mechanism is still unclear. We have therefore investigated the effect of increa...

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Veröffentlicht in:	PloS one 2017-09, Vol.12 (9), p.e0185566-e0185566
Hauptverfasser:	Gschwantler-Kaulich, Daphne, Weingartshofer, Sigrid, Grunt, Thomas W, Mairhofer, Mario, Tan, Yen, Gamper, Jutta, Singer, Christian F
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Acids Anticancer properties Antineoplastic Agents - administration & dosage Antiproliferatives Antitumor activity Apoptosis Apoptosis - drug effects Biology and Life Sciences Biotechnology Bone cancer Bone density Bone Density Conservation Agents - administration & dosage Bone Density Conservation Agents - antagonists & inhibitors Bone Neoplasms - prevention & control Bone Neoplasms - secondary Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cancer therapies Cell Cycle - drug effects Cell death Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Charcoal Chemotherapy Complications and side effects Deoxyribonucleic acid Development and progression Diphosphonates - administration & dosage Diphosphonates - antagonists & inhibitors DNA DNA, Neoplasm - biosynthesis Dosage and administration Drug therapy Estradiol Estradiol - administration & dosage Estradiol - adverse effects Estrogens Female Flow cytometry Gynecology Health risk assessment Humans Imidazoles - administration & dosage Imidazoles - antagonists & inhibitors In vitro methods and tests MCF-7 Cells Medical statistics Medicine and Health Sciences Metastases Metastasis Neoplasms, Hormone-Dependent - drug therapy Neoplasms, Hormone-Dependent - metabolism Neoplasms, Hormone-Dependent - pathology Obstetrics Penicillin Physiological aspects Post-menopause Research and analysis methods Sex hormones Tumor cell lines Tumors Zoledronic acid
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