[18F] FDOPA standardized uptake values of brain tumors are not exclusively dependent on LAT1 expression

[18F]-FDOPA is a labeled amino acid (AA) analog used for positron emission tomography (PET) which is gaining increasing interest in the evaluation of brain tumors (BT). The AA-transporter LAT1 has been shown to be involved in [18F]-FDOPA uptake. The aim of this study was to determine whether the [18...

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Veröffentlicht in:	PloS one 2017-09, Vol.12 (9), p.e0184625-e0184625
Hauptverfasser:	Dadone-Montaudié, Bérengère, Ambrosetti, Damien, Dufour, Maxime, Darcourt, Jacques, Almairac, Fabien, Coyne, John, Virolle, Thierry, Humbert, Olivier, Burel-Vandenbos, Fanny
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Amino Acid Transport Systems, Basic - metabolism Amino acids Biology Biology and Life Sciences Blood-brain barrier Brain Brain - diagnostic imaging Brain - metabolism Brain - pathology Brain - surgery Brain cancer Brain Neoplasms - diagnostic imaging Brain Neoplasms - metabolism Brain Neoplasms - pathology Brain Neoplasms - surgery Brain tumors Chemotherapy Dihydroxyphenylalanine Dihydroxyphenylalanine - pharmacokinetics Dosage and administration Emission analysis Female Fluorine Radioisotopes - pharmacokinetics Gene expression Genetic aspects Glioma Glioma - diagnostic imaging Glioma - metabolism Glioma - pathology Glioma - surgery Humans Immunohistochemistry Male Medical imaging Medicine and Health Sciences Metastases Metastasis Middle Aged Nervous system Nuclear medicine Pathology Positron emission Positron emission tomography Radiation therapy Radiopharmaceuticals - pharmacokinetics Research and Analysis Methods Surgery Tomography Tumors
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