Plant flavones enhance antimicrobial activity of respiratory epithelial cell secretions against Pseudomonas aeruginosa

Flavones are a class of natural plant secondary metabolites that have anti-inflammatory and anti-bacterial effects. Some flavones also activate the T2R14 bitter taste receptor, which is expressed in motile cilia of the sinonasal epithelium and activates innate immune nitric oxide (NO) production. Fl...

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Veröffentlicht in:	PloS one 2017-09, Vol.12 (9), p.e0185203-e0185203
Hauptverfasser:	Hariri, Benjamin M, McMahon, Derek B, Chen, Bei, Adappa, Nithin D, Palmer, James N, Kennedy, David W, Lee, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antibacterial activity Antibiotics Antimicrobial activity Antimicrobial agents Bacteria Bacterial effects Biology and Life Sciences Bitter taste Bronchi - cytology Candida albicans - drug effects Care and treatment Cell Line Chinese medicine Cilia Drug Synergism Epithelial Cells - drug effects Epithelial Cells - microbiology Epithelial Cells - secretion Epithelium Flavones Flavones - pharmacology Flavonoids Genomes Gram-negative bacteria Health aspects Humans Inflammation Kinases Lysozyme Medicine and Health Sciences Metabolites Microbial Sensitivity Tests Microorganisms Muramidase - pharmacology Neck Nitric oxide Otolaryngology Paranasal Sinuses - cytology Physiological aspects Plants - chemistry Proteins Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - pathogenicity Pyocyanin Respiratory tract Respiratory tract diseases Secondary metabolites Secretions Staphylococcus aureus - drug effects Staphylococcus infections Surgery Taste receptors
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