Bifurcation kinetics of drug uptake by Gram-negative bacteria

Cell envelopes of many bacteria consist of two membranes studded with efflux transporters. Such organization protects bacteria from the environment and gives rise to multidrug resistance. We report a kinetic model that accurately describes the permeation properties of this system. The model predicts...

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Veröffentlicht in:	PloS one 2017-09, Vol.12 (9), p.e0184671-e0184671
Hauptverfasser:	Westfall, David A, Krishnamoorthy, Ganesh, Wolloscheck, David, Sarkar, Rupa, Zgurskaya, Helen I, Rybenkov, Valentin V
Format:	Artikel
Sprache:	eng
Schlagworte:	Anomalies Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Antibiotics Bacteria Bacterial Outer Membrane Proteins - metabolism Benzimidazoles - metabolism Bifurcations Biochemistry Biology and Life Sciences Cell envelopes Chemistry Diffusion rate DNA - metabolism Drug resistance E coli Efflux Escherichia coli - metabolism Glycoproteins Gram-negative bacteria Gram-Negative Bacteria - drug effects Gram-Negative Bacteria - growth & development Gram-Negative Bacteria - metabolism Kinetics Medicine and Health Sciences Membranes Models, Biological Multidrug resistance Penetration Permeability Physical Sciences Proteins Salmonella Saturation Transport properties
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