Engaging the CD40-CD40L pathway augments T-helper cell responses and improves control of Mycobacterium tuberculosis infection

Mycobacterium tuberculosis (Mtb) impairs dendritic cell (DC) functions and induces suboptimal antigen-specific CD4 T cell immune responses that are poorly protective. Mucosal T-helper cells producing IFN-γ (Th1) and IL-17 (Th17) are important for protecting against tuberculosis (TB), but the mechani...

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Veröffentlicht in:	PLoS pathogens 2017-08, Vol.13 (8), p.e1006530-e1006530
Hauptverfasser:	Sia, Jonathan Kevin, Bizzell, Erica, Madan-Lala, Ranjna, Rengarajan, Jyothi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Animals Antigens Bacteria Biology and Life Sciences Care and treatment CD4 antigen CD40 antigen CD40 Antigens - immunology CD40 Ligand - immunology CD40L protein Cell culture Coculture Techniques Cytokines Dendritic cells Dendritic Cells - immunology Dendritic Cells - microbiology Disease Models, Animal Drainage Flow Cytometry Health aspects Helper cells Immune response Immune response (cell-mediated) Immunity Immunology Infections Infectious diseases Interleukin 17 Ligands Lungs Lymph nodes Lymphatic system Lymphocyte Activation - immunology Lymphocytes Lymphocytes T Medicine Medicine and Health Sciences Mice Mice, Inbred C57BL Mice, Knockout Mucosa Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Research and Analysis Methods Risk factors Rodents Studies T cell receptors T cells T-Lymphocytes, Helper-Inducer - immunology Trachea Tuberculosis Tuberculosis - immunology Vaccines
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