Cross-reactivity, antivenomics, and neutralization of toxic activities of Lachesis venoms by polyspecific and monospecific antivenoms

Bothrops, Crotalus and Lachesis represent the most medically relevant genera of pitvipers in Central and South America. Similarity in venom phenotype and physiopathological profile of envenomings caused by the four nominal Lachesis species led us to hypothesize that an antivenom prepared against ven...

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Veröffentlicht in:	PLoS neglected tropical diseases 2017-08, Vol.11 (8), p.e0005793-e0005793
Hauptverfasser:	Madrigal, Marvin, Pla, Davinia, Sanz, Libia, Barboza, Elexandra, Arroyo-Portilla, Cynthia, Corrêa-Netto, Carlos, Gutiérrez, José María, Alape-Girón, Alberto, Flores-Díaz, Marietta, Calvete, Juan J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antivenins Antivenins - pharmacology Antivenom Biology and Life Sciences Coagulants Cross Reactions Cross-reactivity Crotalid Venoms - antagonists & inhibitors Dosage and administration Epitopes Equivalence Funding Geographical distribution Hemorrhage Immunization Immunologic Factors - pharmacology Immunoreactivity Medicine and Health Sciences Methods Neutralization Neutralization Tests People and places Phenotypes Proteolysis Proteomics Rattlesnakes Research and Analysis Methods Snakes Species Studies Supervision Taxa Tropical diseases Venom Venoms
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