Kek-6: A truncated-Trk-like receptor for Drosophila neurotrophin 2 regulates structural synaptic plasticity

Neurotrophism, structural plasticity, learning and long-term memory in mammals critically depend on neurotrophins binding Trk receptors to activate tyrosine kinase (TyrK) signaling, but Drosophila lacks full-length Trks, raising the question of how these processes occur in the fly. Paradoxically, tr...

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Veröffentlicht in:	PLoS genetics 2017-08, Vol.13 (8), p.e1006968-e1006968
Hauptverfasser:	Ulian-Benitez, Suzana, Bishop, Simon, Foldi, Istvan, Wentzell, Jill, Okenwa, Chinenye, Forero, Manuel G, Zhu, Bangfu, Moreira, Marta, Phizacklea, Mark, McIlroy, Graham, Li, Guiyi, Gay, Nicholas J, Hidalgo, Alicia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology and Life Sciences Brain Ca2+/calmodulin-dependent protein kinase II Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics Carrier Proteins - genetics Central nervous system Central Nervous System - growth & development Central Nervous System - metabolism Drosophila - genetics Drosophila - physiology Drosophila Proteins - genetics Fruit flies Funding Genes Genomes Glutamatergic transmission Homeostasis Humans Immunoglobulins Insects Isoforms Kinases Larva - metabolism Learning Long term memory Medicine and Health Sciences Membrane Proteins - genetics Motor neurons Motor Neurons - metabolism Nerve Growth Factors - genetics Nerve Growth Factors - metabolism Neuromuscular Junction Neuromuscular junctions Neuronal Plasticity - genetics Neurotrophic factors Neurotrophin 2 Plastic properties Protein Binding Protein-tyrosine kinase Receptor Protein-Tyrosine Kinases - genetics Research and Analysis Methods Signal Transduction Supervision Synaptic plasticity Synaptic Transmission Trk receptors Visualization
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