Persistent mycobacteria evade an antibacterial program mediated by phagolysosomal TLR7/8/MyD88 in human primary macrophages

Pathogenic mycobacteria reside in macrophages where they avoid lysosomal targeting and degradation through poorly understood mechanisms proposed to involve arrest of phagosomal maturation at an early endosomal stage. A clear understanding of how this relates to host defenses elicited from various in...

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Veröffentlicht in:	PLoS pathogens 2017-08, Vol.13 (8), p.e1006551-e1006551
Hauptverfasser:	Gidon, Alexandre, Åsberg, Signe Elisabeth, Louet, Claire, Ryan, Liv, Haug, Markus, Flo, Trude Helen
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Bacteria Biodegradation Biology and Life Sciences Cancer Care and treatment CD63 antigen Compartments Disease Drug resistance Funding Gene expression Health aspects Humans Image Processing, Computer-Assisted Immune system Immunohistochemistry Infection Infections Inflammation Interferon regulatory factor 1 Intracellular Kinases Lysosomes - immunology Macrophages Macrophages - immunology Macrophages - microbiology Maturation Medical research Medicine Medicine and Health Sciences Microscopy, Confocal Mycobacterium avium Mycobacterium Infections - immunology Mycobacterium tuberculosis MyD88 protein Myeloid Differentiation Factor 88 - immunology NF-κB protein Pathogens Phagosomes Phagosomes - immunology Polymerase Chain Reaction Proteins Proteomics Receptors Research and Analysis Methods TLR7 protein Toll-Like Receptor 7 - immunology Toll-like receptors Tolls Transcription factors Tuberculosis
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