Longitudinal multiparameter single-cell analysis of macaques immunized with pneumococcal protein-conjugated or unconjugated polysaccharide vaccines reveals distinct antigen specific memory B cell repertoires

The efficacy of protein-conjugated pneumococcal polysaccharide vaccines has been well characterized for children. The level of protection conferred by unconjugated polysaccharide vaccines remains less clear, particularly for elderly individuals who have had prior antigenic experience through immuniz...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2017-09, Vol.12 (9), p.e0183738
Hauptverfasser:	Jia, Bin, McNeil, Lisa K, Dupont, Christopher D, Tsioris, Konstantinos, Barry, Rachel M, Scully, Ingrid L, Ogunniyi, Adebola O, Gonzalez, Christopher, Pride, Michael W, Gierahn, Todd M, Liberator, Paul A, Jansen, Kathrin U, Love, J Christopher
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Bacterial - immunology Antigens B cells B-Lymphocytes - metabolism Biology and life sciences Cancer Chemical engineering Children Complementarity-determining region 3 Genetic diversity Geriatrics Heptavalent Pneumococcal Conjugate Vaccine - administration & dosage Heptavalent Pneumococcal Conjugate Vaccine - immunology Immune response Immunization Immunization, Secondary Immunoglobulins Immunologic Memory Immunological memory Immunology Influenza Lymphocytes B Macaca - immunology Medical research Medicine and Health Sciences Memory cells Older people Pneumococcal vaccines Pneumococcal Vaccines - administration & dosage Pneumococcal Vaccines - immunology Pneumonia Polymerase chain reaction Polysaccharides Prevention Primates Proteins Research and Analysis Methods Saccharides Single-Cell Analysis Streptococcus infections Streptococcus pneumoniae - immunology T cell receptors Vaccines Variable region
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!