Lack of association of MRI determined subclinical cardiovascular disease with dizziness and vertigo in a cross-sectional population-based study
We investigated the association between subclinical cardiovascular diseases assessed by MRI examination and symptoms of dizziness and vertigo in participants of a population-based sample. Data from 400 participants (169 women) aged from 39 to 73 of a cross-sectional MRI sub-study of the "Kooper...
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| Veröffentlicht in: | PloS one 2017-09, Vol.12 (9), p.e0184858-e0184858 |
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| creator | Lorbeer, Roberto Hetterich, Holger Strobl, Ralf Schafnitzel, Anina Patscheider, Hannah Schindler, Andreas Müller-Peltzer, Katharina Sommer, Wieland Peters, Annette Meisinger, Christa Heier, Margit Rathmann, Wolfgang Bamberg, Fabian Grill, Eva |
| description | We investigated the association between subclinical cardiovascular diseases assessed by MRI examination and symptoms of dizziness and vertigo in participants of a population-based sample.
Data from 400 participants (169 women) aged from 39 to 73 of a cross-sectional MRI sub-study of the "Kooperative Gesundheitsforschung in der Region Augsburg" (KORA) FF4 study from the south of Germany was used. MRI determined subclinical cardiovascular diseases include left and right ventricular structure and function as well as the presence of carotid plaque and carotid wall thickness. Cerebrum diseases include white matter lesions (WML) and cerebral microbleeds (CMB). The main outcomes of dizziness and vertigo were assessed by standardized interview. Logistic regression models were applied and adjusted odds ratios (OR) with 95% confidence intervals (CI) were provided.
Lifetime and 12-month prevalence of dizziness and vertigo were 30% (95%CI 26% to 35%) and 21% (95%CI 17% to 26%) respectively in this sample. On multivariable analysis, cardiac and carotid measurements were not associated with dizziness and vertigo excluding orthostatic vertigo (20%, 95CI 16% to 24%). Only in male participants, there was a significant association between WML and the presence of dizziness and vertigo (OR = 2.95, 95%CI 1.08 to 8.07). There was no significant association of CMB with dizziness and vertigo. However, CMB and WML were tending to associate with a higher risk of dizziness and vertigo in the whole sample (CMB: OR = 1.48, 95%CI 0.70; 3.15; WML: OR = 1.71, 95%CI 0.80 to 3.67;), in persons with prediabetes and diabetes (WML: OR = 2.71, 95%CI 0.89 to 8.23) and in men with normal glucose metabolism (CMB: OR = 2.60, 95%CI 0.56 to 12.0; WML: OR = 3.08, 95%CI 0.58 to 16.5).
In this sample of participants without manifest cardiovascular diseases, subclinical left and right ventricular function and carotid structure were consistently not associated with dizziness and vertigo. Subclinical cerebrum measurements, however, tend to increase the risk for dizziness and vertigo, especially in men and in persons with prediabetes or diabetes. |
| doi_str_mv | 10.1371/journal.pone.0184858 |
| format | Article |
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Data from 400 participants (169 women) aged from 39 to 73 of a cross-sectional MRI sub-study of the "Kooperative Gesundheitsforschung in der Region Augsburg" (KORA) FF4 study from the south of Germany was used. MRI determined subclinical cardiovascular diseases include left and right ventricular structure and function as well as the presence of carotid plaque and carotid wall thickness. Cerebrum diseases include white matter lesions (WML) and cerebral microbleeds (CMB). The main outcomes of dizziness and vertigo were assessed by standardized interview. Logistic regression models were applied and adjusted odds ratios (OR) with 95% confidence intervals (CI) were provided.
Lifetime and 12-month prevalence of dizziness and vertigo were 30% (95%CI 26% to 35%) and 21% (95%CI 17% to 26%) respectively in this sample. On multivariable analysis, cardiac and carotid measurements were not associated with dizziness and vertigo excluding orthostatic vertigo (20%, 95CI 16% to 24%). Only in male participants, there was a significant association between WML and the presence of dizziness and vertigo (OR = 2.95, 95%CI 1.08 to 8.07). There was no significant association of CMB with dizziness and vertigo. However, CMB and WML were tending to associate with a higher risk of dizziness and vertigo in the whole sample (CMB: OR = 1.48, 95%CI 0.70; 3.15; WML: OR = 1.71, 95%CI 0.80 to 3.67;), in persons with prediabetes and diabetes (WML: OR = 2.71, 95%CI 0.89 to 8.23) and in men with normal glucose metabolism (CMB: OR = 2.60, 95%CI 0.56 to 12.0; WML: OR = 3.08, 95%CI 0.58 to 16.5).
In this sample of participants without manifest cardiovascular diseases, subclinical left and right ventricular function and carotid structure were consistently not associated with dizziness and vertigo. Subclinical cerebrum measurements, however, tend to increase the risk for dizziness and vertigo, especially in men and in persons with prediabetes or diabetes.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0184858</identifier><identifier>PMID: 28910373</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Angina pectoris ; Biology and Life Sciences ; Biometrics ; Brain Diseases - diagnostic imaging ; Brain research ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - diagnostic imaging ; Carotid arteries ; Causes of ; Cerebrum ; Confidence intervals ; Cross-Sectional Studies ; Diabetes ; Diabetes mellitus ; Diagnosis ; Dizziness ; Dizziness - epidemiology ; Epidemiology ; Female ; Germany - epidemiology ; Glucose metabolism ; Health aspects ; Heart ; Heart attacks ; Heart diseases ; Hospitals ; Humans ; Information processing ; Lesions ; Logistic Models ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Medicine and Health Sciences ; Metabolism ; Middle Aged ; NMR ; Nuclear magnetic resonance ; Population ; Population studies ; Population-based studies ; Prevalence ; Regression analysis ; Regression models ; Research and Analysis Methods ; Risk Factors ; Stroke ; Structure-function relationships ; Studies ; Substantia alba ; Veins & arteries ; Ventricle ; Ventricular Function ; Vertigo ; Vertigo - epidemiology ; Wall thickness</subject><ispartof>PloS one, 2017-09, Vol.12 (9), p.e0184858-e0184858</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Lorbeer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Lorbeer et al 2017 Lorbeer et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-246710f908763e1e79a5aa7b54dbad6babeebbc8d4b4195e84119c1193f21faa3</citedby><cites>FETCH-LOGICAL-c692t-246710f908763e1e79a5aa7b54dbad6babeebbc8d4b4195e84119c1193f21faa3</cites><orcidid>0000-0002-2224-9208</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599022/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599022/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23864,27922,27923,53789,53791,79370,79371</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28910373$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Tang, Dalin</contributor><creatorcontrib>Lorbeer, Roberto</creatorcontrib><creatorcontrib>Hetterich, Holger</creatorcontrib><creatorcontrib>Strobl, Ralf</creatorcontrib><creatorcontrib>Schafnitzel, Anina</creatorcontrib><creatorcontrib>Patscheider, Hannah</creatorcontrib><creatorcontrib>Schindler, Andreas</creatorcontrib><creatorcontrib>Müller-Peltzer, Katharina</creatorcontrib><creatorcontrib>Sommer, Wieland</creatorcontrib><creatorcontrib>Peters, Annette</creatorcontrib><creatorcontrib>Meisinger, Christa</creatorcontrib><creatorcontrib>Heier, Margit</creatorcontrib><creatorcontrib>Rathmann, Wolfgang</creatorcontrib><creatorcontrib>Bamberg, Fabian</creatorcontrib><creatorcontrib>Grill, Eva</creatorcontrib><title>Lack of association of MRI determined subclinical cardiovascular disease with dizziness and vertigo in a cross-sectional population-based study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>We investigated the association between subclinical cardiovascular diseases assessed by MRI examination and symptoms of dizziness and vertigo in participants of a population-based sample.
Data from 400 participants (169 women) aged from 39 to 73 of a cross-sectional MRI sub-study of the "Kooperative Gesundheitsforschung in der Region Augsburg" (KORA) FF4 study from the south of Germany was used. MRI determined subclinical cardiovascular diseases include left and right ventricular structure and function as well as the presence of carotid plaque and carotid wall thickness. Cerebrum diseases include white matter lesions (WML) and cerebral microbleeds (CMB). The main outcomes of dizziness and vertigo were assessed by standardized interview. Logistic regression models were applied and adjusted odds ratios (OR) with 95% confidence intervals (CI) were provided.
Lifetime and 12-month prevalence of dizziness and vertigo were 30% (95%CI 26% to 35%) and 21% (95%CI 17% to 26%) respectively in this sample. On multivariable analysis, cardiac and carotid measurements were not associated with dizziness and vertigo excluding orthostatic vertigo (20%, 95CI 16% to 24%). Only in male participants, there was a significant association between WML and the presence of dizziness and vertigo (OR = 2.95, 95%CI 1.08 to 8.07). There was no significant association of CMB with dizziness and vertigo. However, CMB and WML were tending to associate with a higher risk of dizziness and vertigo in the whole sample (CMB: OR = 1.48, 95%CI 0.70; 3.15; WML: OR = 1.71, 95%CI 0.80 to 3.67;), in persons with prediabetes and diabetes (WML: OR = 2.71, 95%CI 0.89 to 8.23) and in men with normal glucose metabolism (CMB: OR = 2.60, 95%CI 0.56 to 12.0; WML: OR = 3.08, 95%CI 0.58 to 16.5).
In this sample of participants without manifest cardiovascular diseases, subclinical left and right ventricular function and carotid structure were consistently not associated with dizziness and vertigo. Subclinical cerebrum measurements, however, tend to increase the risk for dizziness and vertigo, especially in men and in persons with prediabetes or diabetes.</description><subject>Adult</subject><subject>Aged</subject><subject>Angina pectoris</subject><subject>Biology and Life Sciences</subject><subject>Biometrics</subject><subject>Brain Diseases - diagnostic imaging</subject><subject>Brain research</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - diagnostic imaging</subject><subject>Carotid arteries</subject><subject>Causes of</subject><subject>Cerebrum</subject><subject>Confidence intervals</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diagnosis</subject><subject>Dizziness</subject><subject>Dizziness - epidemiology</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Germany - epidemiology</subject><subject>Glucose metabolism</subject><subject>Health aspects</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Heart diseases</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Information processing</subject><subject>Lesions</subject><subject>Logistic Models</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Population</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Prevalence</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Research and Analysis Methods</subject><subject>Risk Factors</subject><subject>Stroke</subject><subject>Structure-function relationships</subject><subject>Studies</subject><subject>Substantia alba</subject><subject>Veins & arteries</subject><subject>Ventricle</subject><subject>Ventricular Function</subject><subject>Vertigo</subject><subject>Vertigo - epidemiology</subject><subject>Wall 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of association of MRI determined subclinical cardiovascular disease with dizziness and vertigo in a cross-sectional population-based study</title><author>Lorbeer, Roberto ; Hetterich, Holger ; Strobl, Ralf ; Schafnitzel, Anina ; Patscheider, Hannah ; Schindler, Andreas ; Müller-Peltzer, Katharina ; Sommer, Wieland ; Peters, Annette ; Meisinger, Christa ; Heier, Margit ; Rathmann, Wolfgang ; Bamberg, Fabian ; Grill, Eva</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-246710f908763e1e79a5aa7b54dbad6babeebbc8d4b4195e84119c1193f21faa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Angina pectoris</topic><topic>Biology and Life Sciences</topic><topic>Biometrics</topic><topic>Brain Diseases - diagnostic imaging</topic><topic>Brain research</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular 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Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lorbeer, Roberto</au><au>Hetterich, Holger</au><au>Strobl, Ralf</au><au>Schafnitzel, Anina</au><au>Patscheider, Hannah</au><au>Schindler, Andreas</au><au>Müller-Peltzer, Katharina</au><au>Sommer, Wieland</au><au>Peters, Annette</au><au>Meisinger, Christa</au><au>Heier, Margit</au><au>Rathmann, Wolfgang</au><au>Bamberg, Fabian</au><au>Grill, Eva</au><au>Tang, Dalin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lack of association of MRI determined subclinical cardiovascular disease with dizziness and vertigo in a cross-sectional population-based study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-09-14</date><risdate>2017</risdate><volume>12</volume><issue>9</issue><spage>e0184858</spage><epage>e0184858</epage><pages>e0184858-e0184858</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>We investigated the association between subclinical cardiovascular diseases assessed by MRI examination and symptoms of dizziness and vertigo in participants of a population-based sample.
Data from 400 participants (169 women) aged from 39 to 73 of a cross-sectional MRI sub-study of the "Kooperative Gesundheitsforschung in der Region Augsburg" (KORA) FF4 study from the south of Germany was used. MRI determined subclinical cardiovascular diseases include left and right ventricular structure and function as well as the presence of carotid plaque and carotid wall thickness. Cerebrum diseases include white matter lesions (WML) and cerebral microbleeds (CMB). The main outcomes of dizziness and vertigo were assessed by standardized interview. Logistic regression models were applied and adjusted odds ratios (OR) with 95% confidence intervals (CI) were provided.
Lifetime and 12-month prevalence of dizziness and vertigo were 30% (95%CI 26% to 35%) and 21% (95%CI 17% to 26%) respectively in this sample. On multivariable analysis, cardiac and carotid measurements were not associated with dizziness and vertigo excluding orthostatic vertigo (20%, 95CI 16% to 24%). Only in male participants, there was a significant association between WML and the presence of dizziness and vertigo (OR = 2.95, 95%CI 1.08 to 8.07). There was no significant association of CMB with dizziness and vertigo. However, CMB and WML were tending to associate with a higher risk of dizziness and vertigo in the whole sample (CMB: OR = 1.48, 95%CI 0.70; 3.15; WML: OR = 1.71, 95%CI 0.80 to 3.67;), in persons with prediabetes and diabetes (WML: OR = 2.71, 95%CI 0.89 to 8.23) and in men with normal glucose metabolism (CMB: OR = 2.60, 95%CI 0.56 to 12.0; WML: OR = 3.08, 95%CI 0.58 to 16.5).
In this sample of participants without manifest cardiovascular diseases, subclinical left and right ventricular function and carotid structure were consistently not associated with dizziness and vertigo. Subclinical cerebrum measurements, however, tend to increase the risk for dizziness and vertigo, especially in men and in persons with prediabetes or diabetes.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28910373</pmid><doi>10.1371/journal.pone.0184858</doi><tpages>e0184858</tpages><orcidid>https://orcid.org/0000-0002-2224-9208</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2017-09, Vol.12 (9), p.e0184858-e0184858 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1938824278 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Aged Angina pectoris Biology and Life Sciences Biometrics Brain Diseases - diagnostic imaging Brain research Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - diagnostic imaging Carotid arteries Causes of Cerebrum Confidence intervals Cross-Sectional Studies Diabetes Diabetes mellitus Diagnosis Dizziness Dizziness - epidemiology Epidemiology Female Germany - epidemiology Glucose metabolism Health aspects Heart Heart attacks Heart diseases Hospitals Humans Information processing Lesions Logistic Models Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medicine and Health Sciences Metabolism Middle Aged NMR Nuclear magnetic resonance Population Population studies Population-based studies Prevalence Regression analysis Regression models Research and Analysis Methods Risk Factors Stroke Structure-function relationships Studies Substantia alba Veins & arteries Ventricle Ventricular Function Vertigo Vertigo - epidemiology Wall thickness |
| title | Lack of association of MRI determined subclinical cardiovascular disease with dizziness and vertigo in a cross-sectional population-based study |
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