The human bitter taste receptor T2R38 is broadly tuned for bacterial compounds

T2R38 has been shown to be a specific bacterial detector implicated in innate immune defense mechanism of human upper airway. Several clinical studies have demonstrated that this receptor is associated with the development of chronic rhinosinusitis (CRS). T2R38 was previously reported to bind to hom...

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Veröffentlicht in:	PloS one 2017-09, Vol.12 (9), p.e0181302-e0181302
Hauptverfasser:	Verbeurgt, Christophe, Veithen, Alex, Carlot, Sébastien, Tarabichi, Maxime, Dumont, Jacques E, Hassid, Sergio, Chatelain, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Butyrolactone - analogs & derivatives 4-Butyrolactone - metabolism 4-Butyrolactone - pharmacology Acetone Antigens, Bacterial - immunology Antigens, Bacterial - metabolism Bacteria Biofilms Biology and Life Sciences Bitter taste Butyrolactone Calcium Calcium imaging Chronic Disease Cloning Dimethyl Sulfoxide - metabolism Dimethyl Sulfoxide - pharmacology Gene expression HEK293 Cells Homoserine lactones Hospitals Humans Immune system Immunity, Innate - genetics Interdisciplinary aspects Lactones Medicine and Health Sciences Metabolites Molecular biology Otolaryngology Pathogens Patients Pentanone Physical Sciences Pseudomonas Pseudomonas aeruginosa Quorum Sensing Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - physiology Research and Analysis Methods Respiratory tract Rhinitis - genetics Rhinitis - immunology Rhinosinusitis Sinuses Sinusitis - genetics Sinusitis - immunology Social Sciences Staphylococcus aureus - metabolism Streptococcus infections Streptococcus pneumoniae - metabolism Taste receptors Thiolactone
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