Sigma 1 receptor regulates ERK activation and promotes survival of optic nerve head astrocytes

The sigma 1 receptor (S1R) is a unique transmembrane protein that has been shown to regulate neuronal differentiation and cellular survival. It is expressed within several cell types throughout the nervous system and visceral organs, including neurons and glia within the eye. S1R ligands are therape...

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Veröffentlicht in:	PloS one 2017-09, Vol.12 (9), p.e0184421-e0184421
Hauptverfasser:	Zhao, Jing, Mysona, Barbara A, Wang, Jing, Gonsalvez, Graydon B, Smith, Sylvia B, Bollinger, Kathryn E
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Analgesics, Opioid - pharmacology Animals Apoptosis Astrocytes Astrocytes - drug effects Astrocytes - metabolism Biology and life sciences Brain Cancer Cell death Cell differentiation Cell growth Cell survival Cells, Cultured Cellular biology Differentiation (biology) Extracellular signal-regulated kinase Eye Eye diseases Glaucoma Health aspects HeLa Cells Humans Kinases Ligands Medicine and Health Sciences Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Nervous system Neuronal-glial interactions Neurons Optic nerve Optic Nerve - cytology Optic Nerve - metabolism Organs Oxidative Stress Pentazocine Pentazocine - pharmacology Pharmacology Phosphorylation Phosphotransferases Proteins Rats Rats, Sprague-Dawley Receptors, sigma - agonists Receptors, sigma - metabolism Research and Analysis Methods Rodents Sigma-1 Receptor siRNA Studies Survival Visual perception
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