Genome-wide analysis of parent-of-origin interaction effects with environmental exposure (PoOxE): An application to European and Asian cleft palate trios

Cleft palate only is a common birth defect with high heritability. Only a small fraction of this heritability is explained by the genetic variants identified so far, underscoring the need to investigate other disease mechanisms, such as gene-environment (GxE) interactions and parent-of-origin (PoO)...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2017-09, Vol.12 (9), p.e0184358-e0184358
Hauptverfasser:	Haaland, Øystein A, Jugessur, Astanand, Gjerdevik, Miriam, Romanowska, Julia, Shi, Min, Beaty, Terri H, Marazita, Mary L, Murray, Jeffrey C, Wilcox, Allen J, Lie, Rolv T, Gjessing, Håkon K
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Drinking - epidemiology Alcohol use Alcoholic beverages Asian Continental Ancestry Group Avitaminosis - epidemiology Bioinformatics Biology and Life Sciences Birth defects Carrier Proteins - genetics Cleft lip/palate Cleft palate Cleft Palate - epidemiology Cleft Palate - ethnology Cleft Palate - genetics Congenital defects Data processing Dipeptidase DNA methylation Elongation Environmental aspects Environmental effects Environmental health Environmental toxicology Epidemiology Epigenetics European Continental Ancestry Group Exposure Family studies Female Fetuses Gene-Environment Interaction Genetic aspects Genetic variance Genetics Genome-Wide Association Study Genomes Genotypes Glutamate Carboxypeptidase II - genetics Health sciences Heritability Humans Male Maternal Exposure - adverse effects Medicine and Health Sciences Methods People and Places Physical Sciences Polymorphism, Single Nucleotide Primary care Public health Single-nucleotide polymorphism Smoking Smoking - epidemiology Vitamins
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!