Histone deacetylase regulates insulin signaling via two pathways in pancreatic β cells

Recent studies demonstrated that insulin signaling plays important roles in the regulation of pancreatic β cell mass, the reduction of which is known to be involved in the development of diabetes. However, the mechanism underlying the alteration of insulin signaling in pancreatic β cells remains unc...

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Veröffentlicht in:	PloS one 2017-09, Vol.12 (9), p.e0184435-e0184435
Hauptverfasser:	Kawada, Yukina, Asahara, Shun-Ichiro, Sugiura, Yumiko, Sato, Ayaka, Furubayashi, Ayuko, Kawamura, Mao, Bartolome, Alberto, Terashi-Suzuki, Emi, Takai, Tomoko, Kanno, Ayumi, Koyanagi-Kimura, Maki, Matsuda, Tomokazu, Hashimoto, Naoko, Kido, Yoshiaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Biology and Life Sciences Biophysics Birth weight Cell Line, Tumor Cell Proliferation Control Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Disease Models, Animal Endocrinology Epigenetics FDA approval Gene Expression Gene Expression Regulation - drug effects Health sciences Histone deacetylase Histone Deacetylase Inhibitors - pharmacology Histone Deacetylases - metabolism Histones - metabolism Insulin Insulin - metabolism Insulin Receptor Substrate Proteins - genetics Insulin Receptor Substrate Proteins - metabolism Insulin resistance Insulin-Secreting Cells - metabolism Insulinoma Internal medicine Lysine Medical technology Medicine Medicine and Health Sciences Metabolism Mice Mice, Knockout Models, Biological Neuroendocrine tumors Pancreas Phosphorylation Physical Sciences Promoter Regions, Genetic Research and Analysis Methods Rodents Signal transduction Signal Transduction - drug effects Tyrosine University graduates
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