Lower frequency of TLR9 variant associated with protection from breast cancer among African Americans

Toll-like receptor 9 (TLR9) is an innate immune system DNA-receptor that regulates tumor invasion and immunity in vitro. Low tumor TLR9 expression has been associated with poor survival in Caucasian patients with triple negative breast cancer (TNBC). African American (AA) patients with TNBC have wor...

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Veröffentlicht in:	PloS one 2017-09, Vol.12 (9), p.e0183832-e0183832
Hauptverfasser:	Chandler, Madison R, Keene, Kimberly S, Tuomela, Johanna M, Forero-Torres, Andres, Desmond, Renee, Vuopala, Katri S, Harris, Kevin W, Merner, Nancy D, Selander, Katri S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult African Americans - genetics Aged Alleles Bioinformatics Biology and Life Sciences Biomarkers, Tumor - genetics Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer CpG islands Deoxyribonucleic acid DNA DNA methylation European Continental Ancestry Group - genetics Female Gene expression Gene frequency Gene Frequency - genetics Genetic diversity Genomes Health risks Hematology Humans Immune system Immunity Immunohistochemistry In vitro methods and tests In Vitro Techniques Innate immunity Ligands Medical diagnosis Medical prognosis Medicine Medicine and Health Sciences Meningitis Middle Aged Minority & ethnic groups Oncology Pathology Patients Polymorphism, Single Nucleotide - genetics Population genetics Prognosis Prostate Proteins Research and Analysis Methods Statistical analysis Statistical significance TLR9 protein Toll-Like Receptor 9 - genetics Toll-like receptors Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - pathology Tumors Womens health
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