Directional migration of mesenchymal stem cells under an SDF-1α gradient on a microfluidic device

Homing of peripheral stem cells is regulated by one of the most representative homing factors, stromal cell-derived factor 1 alpha (SDF-1α), which specifically binds to the plasma membrane receptor CXCR4 of mesenchymal stem cells (MSCs) in order to initiate the signaling pathways that lead to direct...

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Veröffentlicht in:	PloS one 2017-09, Vol.12 (9), p.e0184595
Hauptverfasser:	Park, Siwan, Jang, Hwanseok, Kim, Byung Soo, Hwang, Changmo, Jeong, Gi Seok, Park, Yongdoo
Format:	Artikel
Sprache:	eng
Schlagworte:	Actomyosin Amides - pharmacology Aminoquinolines - pharmacology Biology and Life Sciences Biomedical engineering Blockage Blood vessels Brain research Cancer Cell adhesion & migration Cell migration Cell Movement - drug effects Chemokine CXCL12 - chemistry Chemokines Collagen CXCR4 protein Cytokines Embedding Endothelium Engineering and Technology Heterocyclic Compounds - pharmacology Homing Human Umbilical Vein Endothelial Cells Humans Immunohistochemistry Kinases Lab-On-A-Chip Devices Lamellipodia Leukocyte migration Life sciences Medical research Medicine Medicine and Health Sciences Mesenchymal stem cells Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - drug effects Mesenchyme Microfluidics Microscopy, Confocal Monolayers Pathways Physiology Proteins Pseudopodia Pyridines - pharmacology Pyrimidines - pharmacology rac GTP-Binding Proteins - antagonists & inhibitors rac GTP-Binding Proteins - metabolism rho GTP-Binding Proteins - antagonists & inhibitors rho GTP-Binding Proteins - metabolism Rodents SDF-1 protein Signal transduction Signal Transduction - drug effects Stem cells
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