Liver stiffness measurement predicts liver-related events in patients with chronic hepatitis C: A retrospective study
The management of patients with chronic hepatitis C (CHC) depends on their clinical stage. Thus, noninvasive early recognition of patients with CHC at high risk for developing liver-related events (LREs) is important because it ensures optimal preventative management strategies may be employed that...
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| description | The management of patients with chronic hepatitis C (CHC) depends on their clinical stage. Thus, noninvasive early recognition of patients with CHC at high risk for developing liver-related events (LREs) is important because it ensures optimal preventative management strategies may be employed that can affect the course of CHC disease. Our aim was to determine whether liver stiffness measurement (LSM) in hepatitis C virus (HCV)-infected patients is associated with a risk of LREs, particularly in cirrhotic patients. We carried out a retrospective study on 343 HCV-infected patients stratified according to cirrhosis (LSM |
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Thus, noninvasive early recognition of patients with CHC at high risk for developing liver-related events (LREs) is important because it ensures optimal preventative management strategies may be employed that can affect the course of CHC disease. Our aim was to determine whether liver stiffness measurement (LSM) in hepatitis C virus (HCV)-infected patients is associated with a risk of LREs, particularly in cirrhotic patients. We carried out a retrospective study on 343 HCV-infected patients stratified according to cirrhosis (LSM<12.5 kPa vs. LSM≥12.5 kPa), and the cirrhotic patient group (LSM≥12.5 kPa) was divided according to risk of esophageal varices (LSM <25 kPa vs. LSM≥25 kPa). For all patients, each incremental unit in the natural logarithm (Ln) of LSM was associated with 14.76 times higher risk of developing LREs (p<0.001). Patients with cirrhosis (LSM≥12.5 kPa) had a higher risk of LREs than patients without cirrhosis (LSM<12.5 kPa) [adjusted hazard ratio (aHR) = 30.97; p<0.001]. When only cirrhotic patients were analyzed (n = 60), each incremental unit in the Ln of LSM was associated with 10.56 times higher risk of developing LREs (p = 0.010). Patients with LSM≥25 kPa had a greater risk for LRE development compared to those with LSM<25 kPa (aHR = 3.65; p = 0.045). The AUROC for predicting the onset of LREs was 0.876 in all patients and 0.729 in cirrhotic patients. In conclusion, LSM was associated with an increased risk of developing LREs in HCV-infected patients, even within the group of cirrhotic patients.]]></description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0184404</identifier><identifier>PMID: 28880930</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Alcohol use ; Antiviral drugs ; Biology and life sciences ; Causes of ; Cirrhosis ; Complications and side effects ; Diagnosis ; Esophagus ; Female ; Gastroenterology ; Hepatitis ; Hepatitis B, Chronic - pathology ; Hepatitis B, Chronic - physiopathology ; Hepatitis C ; Hepatitis C, Chronic - pathology ; Hepatitis C, Chronic - physiopathology ; HIV ; Hospitals ; Human immunodeficiency virus ; Humans ; Hypertension ; Interferon ; Kaplan-Meier Estimate ; Laboratories ; Liver ; Liver - pathology ; Liver cancer ; Liver cirrhosis ; Liver Cirrhosis - pathology ; Liver Cirrhosis - physiopathology ; Liver diseases ; Male ; Medicine and Health Sciences ; Middle Aged ; Patients ; Physical Sciences ; Proportional Hazards Models ; Research and Analysis Methods ; Retrospective Studies ; Risk ; ROC Curve ; Stiffness ; Ultrasonic imaging ; Viruses</subject><ispartof>PloS one, 2017-09, Vol.12 (9), p.e0184404-e0184404</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Gomez-Moreno et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Gomez-Moreno et al 2017 Gomez-Moreno et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-6030bdfd39cc01eb059da55d2bf079181ca6c8cc304b21c01bb0d5c1e20a13373</citedby><cites>FETCH-LOGICAL-c692t-6030bdfd39cc01eb059da55d2bf079181ca6c8cc304b21c01bb0d5c1e20a13373</cites><orcidid>0000-0001-8783-0450</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589221/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589221/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28880930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gomez-Moreno, Ana Zaida</creatorcontrib><creatorcontrib>Pineda-Tenor, Daniel</creatorcontrib><creatorcontrib>Jimenez-Sousa, Maria Angeles</creatorcontrib><creatorcontrib>Sánchez-Ruano, Juan Jose</creatorcontrib><creatorcontrib>Artaza-Varasa, Tomas</creatorcontrib><creatorcontrib>Saura-Montalban, Jose</creatorcontrib><creatorcontrib>Ryan, Pablo</creatorcontrib><creatorcontrib>Resino, Salvador</creatorcontrib><title>Liver stiffness measurement predicts liver-related events in patients with chronic hepatitis C: A retrospective study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description><![CDATA[The management of patients with chronic hepatitis C (CHC) depends on their clinical stage. Thus, noninvasive early recognition of patients with CHC at high risk for developing liver-related events (LREs) is important because it ensures optimal preventative management strategies may be employed that can affect the course of CHC disease. Our aim was to determine whether liver stiffness measurement (LSM) in hepatitis C virus (HCV)-infected patients is associated with a risk of LREs, particularly in cirrhotic patients. We carried out a retrospective study on 343 HCV-infected patients stratified according to cirrhosis (LSM<12.5 kPa vs. LSM≥12.5 kPa), and the cirrhotic patient group (LSM≥12.5 kPa) was divided according to risk of esophageal varices (LSM <25 kPa vs. LSM≥25 kPa). For all patients, each incremental unit in the natural logarithm (Ln) of LSM was associated with 14.76 times higher risk of developing LREs (p<0.001). Patients with cirrhosis (LSM≥12.5 kPa) had a higher risk of LREs than patients without cirrhosis (LSM<12.5 kPa) [adjusted hazard ratio (aHR) = 30.97; p<0.001]. When only cirrhotic patients were analyzed (n = 60), each incremental unit in the Ln of LSM was associated with 10.56 times higher risk of developing LREs (p = 0.010). Patients with LSM≥25 kPa had a greater risk for LRE development compared to those with LSM<25 kPa (aHR = 3.65; p = 0.045). The AUROC for predicting the onset of LREs was 0.876 in all patients and 0.729 in cirrhotic patients. In conclusion, LSM was associated with an increased risk of developing LREs in HCV-infected patients, even within the group of cirrhotic patients.]]></description><subject>Adult</subject><subject>Alcohol use</subject><subject>Antiviral drugs</subject><subject>Biology and life sciences</subject><subject>Causes of</subject><subject>Cirrhosis</subject><subject>Complications and side effects</subject><subject>Diagnosis</subject><subject>Esophagus</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Hepatitis</subject><subject>Hepatitis B, Chronic - pathology</subject><subject>Hepatitis B, Chronic - physiopathology</subject><subject>Hepatitis C</subject><subject>Hepatitis C, Chronic - pathology</subject><subject>Hepatitis C, Chronic - physiopathology</subject><subject>HIV</subject><subject>Hospitals</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Interferon</subject><subject>Kaplan-Meier Estimate</subject><subject>Laboratories</subject><subject>Liver</subject><subject>Liver - pathology</subject><subject>Liver cancer</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis - pathology</subject><subject>Liver Cirrhosis - physiopathology</subject><subject>Liver diseases</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Physical Sciences</subject><subject>Proportional Hazards Models</subject><subject>Research and Analysis Methods</subject><subject>Retrospective Studies</subject><subject>Risk</subject><subject>ROC Curve</subject><subject>Stiffness</subject><subject>Ultrasonic imaging</subject><subject>Viruses</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7rr6D0QDgujFjEnT9MMLYRj8GBhY8Os2pMnpNEPb1CQd3X9vOtNdprIX0ouEk-e8J3l7ThQ9J3hJaEbe7c1gO9Ese9PBEpM8SXDyILokBY0XaYzpw7P9RfTEuT3GjOZp-ji6iPM8xwXFl9Gw1QewyHldVR04h1oQbrDQQudRb0Fp6R1qRmhhoREeFIJDOHRId6gXXh_3v7Wvkayt6bRENYxxrx1av0crZMFb43qQPqiESoO6eRo9qkTj4Nm0XkU_Pn38vv6y2F5_3qxX24VMi9gvUkxxqSpFCykxgRKzQgnGVFxWOCtITqRIZS4lxUkZk4CUJVZMEoixIJRm9Cp6edLtG-P45JjjwZeU4SyP00BsToQyYs97q1thb7gRmh8Dxu64sF7LBrgQVSxJUjGWpUmVkEIpJVkoRwUNd5BB68NUbShbUDI4Y0UzE52fdLrmO3PgjOVFHJMg8GYSsObXAM7zVjsJTSM6MMPx3hmLSZGO6Kt_0PtfN1E7ER6gu8qEunIU5SuGQxcxQkaXlvdQ4VPQahnaq9IhPkt4O0sIjIc_ficG5_jm29f_Z69_ztnXZ2wNovG1M83gtencHExOoAyd5SxUdyYTzMfpuHWDj9PBp-kIaS_Of9Bd0u040L_xewxB</recordid><startdate>20170907</startdate><enddate>20170907</enddate><creator>Gomez-Moreno, Ana Zaida</creator><creator>Pineda-Tenor, Daniel</creator><creator>Jimenez-Sousa, Maria Angeles</creator><creator>Sánchez-Ruano, Juan Jose</creator><creator>Artaza-Varasa, Tomas</creator><creator>Saura-Montalban, Jose</creator><creator>Ryan, Pablo</creator><creator>Resino, Salvador</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-8783-0450</orcidid></search><sort><creationdate>20170907</creationdate><title>Liver stiffness measurement predicts liver-related events in patients with chronic hepatitis C: A retrospective study</title><author>Gomez-Moreno, Ana Zaida ; Pineda-Tenor, Daniel ; Jimenez-Sousa, Maria Angeles ; Sánchez-Ruano, Juan Jose ; Artaza-Varasa, Tomas ; Saura-Montalban, Jose ; Ryan, Pablo ; Resino, Salvador</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-6030bdfd39cc01eb059da55d2bf079181ca6c8cc304b21c01bb0d5c1e20a13373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Alcohol use</topic><topic>Antiviral drugs</topic><topic>Biology and life sciences</topic><topic>Causes of</topic><topic>Cirrhosis</topic><topic>Complications and side effects</topic><topic>Diagnosis</topic><topic>Esophagus</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Hepatitis</topic><topic>Hepatitis B, Chronic - 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Thus, noninvasive early recognition of patients with CHC at high risk for developing liver-related events (LREs) is important because it ensures optimal preventative management strategies may be employed that can affect the course of CHC disease. Our aim was to determine whether liver stiffness measurement (LSM) in hepatitis C virus (HCV)-infected patients is associated with a risk of LREs, particularly in cirrhotic patients. We carried out a retrospective study on 343 HCV-infected patients stratified according to cirrhosis (LSM<12.5 kPa vs. LSM≥12.5 kPa), and the cirrhotic patient group (LSM≥12.5 kPa) was divided according to risk of esophageal varices (LSM <25 kPa vs. LSM≥25 kPa). For all patients, each incremental unit in the natural logarithm (Ln) of LSM was associated with 14.76 times higher risk of developing LREs (p<0.001). Patients with cirrhosis (LSM≥12.5 kPa) had a higher risk of LREs than patients without cirrhosis (LSM<12.5 kPa) [adjusted hazard ratio (aHR) = 30.97; p<0.001]. When only cirrhotic patients were analyzed (n = 60), each incremental unit in the Ln of LSM was associated with 10.56 times higher risk of developing LREs (p = 0.010). Patients with LSM≥25 kPa had a greater risk for LRE development compared to those with LSM<25 kPa (aHR = 3.65; p = 0.045). The AUROC for predicting the onset of LREs was 0.876 in all patients and 0.729 in cirrhotic patients. In conclusion, LSM was associated with an increased risk of developing LREs in HCV-infected patients, even within the group of cirrhotic patients.]]></abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28880930</pmid><doi>10.1371/journal.pone.0184404</doi><tpages>e0184404</tpages><orcidid>https://orcid.org/0000-0001-8783-0450</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Alcohol use Antiviral drugs Biology and life sciences Causes of Cirrhosis Complications and side effects Diagnosis Esophagus Female Gastroenterology Hepatitis Hepatitis B, Chronic - pathology Hepatitis B, Chronic - physiopathology Hepatitis C Hepatitis C, Chronic - pathology Hepatitis C, Chronic - physiopathology HIV Hospitals Human immunodeficiency virus Humans Hypertension Interferon Kaplan-Meier Estimate Laboratories Liver Liver - pathology Liver cancer Liver cirrhosis Liver Cirrhosis - pathology Liver Cirrhosis - physiopathology Liver diseases Male Medicine and Health Sciences Middle Aged Patients Physical Sciences Proportional Hazards Models Research and Analysis Methods Retrospective Studies Risk ROC Curve Stiffness Ultrasonic imaging Viruses |
| title | Liver stiffness measurement predicts liver-related events in patients with chronic hepatitis C: A retrospective study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T15%3A37%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Liver%20stiffness%20measurement%20predicts%20liver-related%20events%20in%20patients%20with%20chronic%20hepatitis%20C:%20A%20retrospective%20study&rft.jtitle=PloS%20one&rft.au=Gomez-Moreno,%20Ana%20Zaida&rft.date=2017-09-07&rft.volume=12&rft.issue=9&rft.spage=e0184404&rft.epage=e0184404&rft.pages=e0184404-e0184404&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0184404&rft_dat=%3Cgale_plos_%3EA503715117%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1936507826&rft_id=info:pmid/28880930&rft_galeid=A503715117&rft_doaj_id=oai_doaj_org_article_aaf2c14f55764f419dddc55c13a3cc3c&rfr_iscdi=true |