TGF-β signaling is an effective target to impair survival and induce apoptosis of human cholangiocarcinoma cells: A study on human primary cell cultures

Cholangiocarcinoma (CCA) and its subtypes (mucin- and mixed-CCA) arise from the neoplastic transformation of cholangiocytes, the epithelial cells lining the biliary tree. CCA has a high mortality rate owing to its aggressiveness, late diagnosis and high resistance to radiotherapy and chemotherapeuti...

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Veröffentlicht in:	PloS one 2017-09, Vol.12 (9), p.e0183932-e0183932
Hauptverfasser:	Lustri, Anna Maria, Di Matteo, Sabina, Fraveto, Alice, Costantini, Daniele, Cantafora, Alfredo, Napoletano, Chiara, Bragazzi, Maria Consiglia, Giuliante, Felice, De Rose, Agostino M, Berloco, Pasquale B, Grazi, Gian Luca, Carpino, Guido, Alvaro, Domenico
Format:	Artikel
Sprache:	eng
Schlagworte:	Annexin V Anticancer properties Apoptosis Biology and Life Sciences Biomarkers Biotechnology Cadherins Cancer Casein Cell adhesion & migration Cell culture Cell growth Cell Line, Tumor Cell migration Cell Movement Cell proliferation Cell Survival Cholangiocarcinoma Cholangiocarcinoma - metabolism Cholangiocarcinoma - pathology Deoxyribonucleic acid DNA DNA damage Drug resistance Drug Resistance, Neoplasm Enzyme inhibitors Epidermal growth factor Epithelial cells Epithelial-Mesenchymal Transition Gene expression Healing High resistance Humans Inhibitors Kinases Medical prognosis Medicine Mesenchyme Mucin N-Cadherin Naphthyridines - chemistry Neoplastic Stem Cells - cytology Primary Cell Culture Proteins Pyrazoles - chemistry Quinolines - chemistry Radiation therapy Research and Analysis Methods Signal Transduction Stem cells Transformation Transforming Growth Factor beta - metabolism Transforming growth factor-b1 Vimentin Wound Healing
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