Dual specificity phosphatase 6 deficiency is associated with impaired systemic glucose tolerance and reversible weight retardation in mice

Here, we aimed to investigate the potential role of DUSP6, a dual specificity phosphatase, that specifically inactivates extracellular signal-regulated kinase (ERK), for the regulation of body weight and glucose homeostasis. We further assessed whether metabolic challenges affect Dusp6 expression in...

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Veröffentlicht in:	PloS one 2017-09, Vol.12 (9), p.e0183488-e0183488
Hauptverfasser:	Pfuhlmann, Katrin, Pfluger, Paul T, Schriever, Sonja C, Müller, Timo D, Tschöp, Matthias H, Stemmer, Kerstin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipose tissue Adipose Tissue, White - metabolism Age Animals Biology and Life Sciences Body Composition Body fat Body Weight Brain Brain research Cholesterol Control Diabetes Diet Diet, High-Fat Differentiation Dual Specificity Phosphatase 6 - deficiency Dual Specificity Phosphatase 6 - genetics Dual Specificity Phosphatase 6 - metabolism Energy metabolism Environmental factors Epididymis - metabolism Exposure Extracellular signal-regulated kinase Fasting Gene expression Gene Expression Profiling Genomes Genotype & phenotype Glucose Glucose Intolerance - complications Glucose Intolerance - enzymology Glucose Intolerance - genetics Glucose Intolerance - pathology Glucose metabolism Glucose tolerance Health aspects High fat diet Homeostasis Hypothalamus In vitro methods and tests Intestinal microflora Intolerance Kinases Leptin Leptin - metabolism Light emitting diodes Lipid Metabolism Male Medicine and Health Sciences Messenger RNA Metabolic disorders Metabolic syndrome Metabolism Mice Mice, Inbred C57BL Mice, Knockout Mitogen-activated protein kinases mRNA Neurobiology Neurosciences Nutritional Physiological Phenomena Obesity Obesity - complications Obesity - genetics Phosphatase Physiological aspects Physiology Proteins RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Weight control Weight reduction
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