Anti-fibrotic effects of valproic acid in experimental peritoneal fibrosis

Progressive fibrous thickening of the peritoneal membrane is a complication of long-term peritoneal dialysis (PD). TGF-β/Smad pathway activation, inflammation, and neoangiogenesis play important roles in peritoneal membrane (PM) changes induced by PD. Recently, histone deacetilase inhibitors (HDACi)...

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Veröffentlicht in:	PloS one 2017-09, Vol.12 (9), p.e0184302-e0184302
Hauptverfasser:	Costalonga, Elerson C, de Freitas, Luiza J, Aragone, Deise da S P, Silva, Filipe M O, Noronha, Irene L
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Acids Analysis Animals Biological Transport - drug effects Biology and Life Sciences Biomarkers - metabolism Body Weight - drug effects Bone Morphogenetic Protein 7 - genetics Bone Morphogenetic Protein 7 - metabolism Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Capillaries - metabolism Cell Count Chlorhexidine Chromatin Complications Cytokines Cytokines - metabolism Deacetylation Development and progression Dialysis Dosage and administration Drug therapy Drugs Fibronectin Fibronectins - genetics Fibronectins - metabolism Fibrosis Gene expression Gene Expression Regulation - drug effects Histones Immunofluorescence Immunohistochemistry Inflammation Inflammation - pathology Inflammation Mediators Interleukin 1 Kidney diseases Laboratories Male Medical schools Medicine and Health Sciences Monocyte chemoattractant protein 1 Mortality Multiplexing Myofibroblasts - drug effects Myofibroblasts - metabolism Myofibroblasts - pathology Neovascularization, Physiologic Nephrology Peritoneal dialysis Peritoneal Fibrosis - chemically induced Peritoneal Fibrosis - drug therapy Peritoneal Fibrosis - genetics Peritoneal Fibrosis - pathology Peritoneum Peritoneum - drug effects Peritoneum - metabolism Peritoneum - pathology Proteins Rats Rats, Wistar Research and Analysis Methods RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Signal transduction Signal Transduction - drug effects Smad protein Smad Proteins - metabolism Smad3 protein Smad7 protein Studies Thickening Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Treatment Outcome Tumor necrosis factor Ultrafiltration Valproic acid Valproic Acid - pharmacology Valproic Acid - therapeutic use Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism
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