Neuropsychological functioning, age, and medication adherence in bipolar disorder
Poor adherence to medication is frequent in bipolar disorder (BD) and has been associated with several factors. To date, the relationship between low adherence and neuropsychological functioning in BD is still unclear. As age and neuropsychological functioning might have opposing influences on adher...
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| Veröffentlicht in: | PloS one 2017-09, Vol.12 (9), p.e0184313 |
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| creator | Corréard, Nadia Consoloni, Julia-Lou Raust, Aurélie Etain, Bruno Guillot, Romain Job, Sophie Loftus, Joséphine Médecin, Isabelle Bougerol, Thierry Polosan, Mircea Fredembach, Benjamin Gard, Sébastien M'Bailara, Katia Kahn, Jean-Pierre Roux, Paul Homassel, Anne-Sophie Carminati, Mathilde Matos, Lucile Olié, Emilie Bellivier, Frank Courtet, Philippe Henry, Chantal Leboyer, Marion Azorin, Jean-Michel Belzeaux, Raoul |
| description | Poor adherence to medication is frequent in bipolar disorder (BD) and has been associated with several factors. To date, the relationship between low adherence and neuropsychological functioning in BD is still unclear. As age and neuropsychological functioning might have opposing influences on adherence, our aim was to investigate this link with a particular focus on the effect of age.
In a cross-sectional study, we included 353 patients divided into two age-groups (16-46; 47-71) from a French cohort diagnosed with BD (type I, II, NOS) and strictly euthymic. All patients had a standardized clinical and neuropsychological assessment and were categorized as high (n = 186) or low (n = 167) adherent based on their score from the Medication Adherence Rating Scale. Clinical information was collected based on a standardized interview and clinical validated scales. Neuropsychological performances were evaluated with an established standardized neuropsychological battery for bipolar disorder patients. After univariate analysis, neuropsychological and clinical predictors of low adherence were included in two age-specific stepwise multiple logistic regressions.
A smaller number of hospitalizations (OR = 0.846, p = 0.012), a shorter illness duration (OR = 0.937, p = 0.003) and higher adverse effects (OR = 1.082, p |
| doi_str_mv | 10.1371/journal.pone.0184313 |
| format | Article |
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In a cross-sectional study, we included 353 patients divided into two age-groups (16-46; 47-71) from a French cohort diagnosed with BD (type I, II, NOS) and strictly euthymic. All patients had a standardized clinical and neuropsychological assessment and were categorized as high (n = 186) or low (n = 167) adherent based on their score from the Medication Adherence Rating Scale. Clinical information was collected based on a standardized interview and clinical validated scales. Neuropsychological performances were evaluated with an established standardized neuropsychological battery for bipolar disorder patients. After univariate analysis, neuropsychological and clinical predictors of low adherence were included in two age-specific stepwise multiple logistic regressions.
A smaller number of hospitalizations (OR = 0.846, p = 0.012), a shorter illness duration (OR = 0.937, p = 0.003) and higher adverse effects (OR = 1.082, p<0.001) were associated with a greater risk of low adherence in the younger patients. In the older patients, low adherence was also predicted by a smaller number of hospitalizations (OR = 0.727, p = 0.008) and higher adverse effects (OR = 1.124, p = 0.005). Interestingly poor inhibition performance was also a significant predictor of low adherence in older patients (OR = 0.924, p = 0.030).
We found an age-specific relationship between cognitive functioning and adherence in patients with BD. Poor inhibition performances predicted low adherence in older patients only. Our results highlight the need to provide age-adapted therapeutic interventions to improve adherence in patients with BD.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0184313</identifier><identifier>PMID: 28873468</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adhesion ; Adult ; Age ; Age Factors ; Aged ; Aging ; Analysis ; Biology and Life Sciences ; Bipolar disorder ; Bipolar Disorder - psychology ; Care and treatment ; Clinical psychology ; Cognitive ability ; Cognitive science ; Cooperation ; Demography ; Diagnosis ; Drugs ; Female ; Health aspects ; Health sciences ; Humans ; Inhibition ; Inhibition (psychology) ; Logistic Models ; Male ; Medication Adherence ; Medicine and Health Sciences ; Memory ; Middle Aged ; Neuropsychological Tests ; Neuropsychology ; Neuroscience ; Neurosciences ; Nitric-oxide synthase ; Patient compliance ; Patients ; Psychiatrists ; Psychiatry ; Psychotherapy ; Regression analysis ; Side effects ; Social Sciences ; Subacute care ; Therapeutic applications ; Toxicology ; Veil, Simone</subject><ispartof>PloS one, 2017-09, Vol.12 (9), p.e0184313</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Corréard et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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To date, the relationship between low adherence and neuropsychological functioning in BD is still unclear. As age and neuropsychological functioning might have opposing influences on adherence, our aim was to investigate this link with a particular focus on the effect of age.
In a cross-sectional study, we included 353 patients divided into two age-groups (16-46; 47-71) from a French cohort diagnosed with BD (type I, II, NOS) and strictly euthymic. All patients had a standardized clinical and neuropsychological assessment and were categorized as high (n = 186) or low (n = 167) adherent based on their score from the Medication Adherence Rating Scale. Clinical information was collected based on a standardized interview and clinical validated scales. Neuropsychological performances were evaluated with an established standardized neuropsychological battery for bipolar disorder patients. After univariate analysis, neuropsychological and clinical predictors of low adherence were included in two age-specific stepwise multiple logistic regressions.
A smaller number of hospitalizations (OR = 0.846, p = 0.012), a shorter illness duration (OR = 0.937, p = 0.003) and higher adverse effects (OR = 1.082, p<0.001) were associated with a greater risk of low adherence in the younger patients. In the older patients, low adherence was also predicted by a smaller number of hospitalizations (OR = 0.727, p = 0.008) and higher adverse effects (OR = 1.124, p = 0.005). Interestingly poor inhibition performance was also a significant predictor of low adherence in older patients (OR = 0.924, p = 0.030).
We found an age-specific relationship between cognitive functioning and adherence in patients with BD. Poor inhibition performances predicted low adherence in older patients only. Our results highlight the need to provide age-adapted therapeutic interventions to improve adherence in patients with BD.</description><subject>Adhesion</subject><subject>Adult</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aging</subject><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Bipolar disorder</subject><subject>Bipolar Disorder - psychology</subject><subject>Care and treatment</subject><subject>Clinical psychology</subject><subject>Cognitive ability</subject><subject>Cognitive science</subject><subject>Cooperation</subject><subject>Demography</subject><subject>Diagnosis</subject><subject>Drugs</subject><subject>Female</subject><subject>Health aspects</subject><subject>Health sciences</subject><subject>Humans</subject><subject>Inhibition</subject><subject>Inhibition (psychology)</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medication Adherence</subject><subject>Medicine and Health Sciences</subject><subject>Memory</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests</subject><subject>Neuropsychology</subject><subject>Neuroscience</subject><subject>Neurosciences</subject><subject>Nitric-oxide synthase</subject><subject>Patient compliance</subject><subject>Patients</subject><subject>Psychiatrists</subject><subject>Psychiatry</subject><subject>Psychotherapy</subject><subject>Regression analysis</subject><subject>Side effects</subject><subject>Social Sciences</subject><subject>Subacute care</subject><subject>Therapeutic applications</subject><subject>Toxicology</subject><subject>Veil, 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(HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Corréard, Nadia</au><au>Consoloni, Julia-Lou</au><au>Raust, Aurélie</au><au>Etain, Bruno</au><au>Guillot, Romain</au><au>Job, Sophie</au><au>Loftus, Joséphine</au><au>Médecin, Isabelle</au><au>Bougerol, Thierry</au><au>Polosan, Mircea</au><au>Fredembach, Benjamin</au><au>Gard, Sébastien</au><au>M'Bailara, Katia</au><au>Kahn, Jean-Pierre</au><au>Roux, Paul</au><au>Homassel, Anne-Sophie</au><au>Carminati, Mathilde</au><au>Matos, Lucile</au><au>Olié, Emilie</au><au>Bellivier, Frank</au><au>Courtet, Philippe</au><au>Henry, Chantal</au><au>Leboyer, Marion</au><au>Azorin, Jean-Michel</au><au>Belzeaux, Raoul</au><aucorp>FACE-BD collaborators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuropsychological functioning, age, and medication adherence in bipolar disorder</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-09-05</date><risdate>2017</risdate><volume>12</volume><issue>9</issue><spage>e0184313</spage><pages>e0184313-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Poor adherence to medication is frequent in bipolar disorder (BD) and has been associated with several factors. To date, the relationship between low adherence and neuropsychological functioning in BD is still unclear. As age and neuropsychological functioning might have opposing influences on adherence, our aim was to investigate this link with a particular focus on the effect of age.
In a cross-sectional study, we included 353 patients divided into two age-groups (16-46; 47-71) from a French cohort diagnosed with BD (type I, II, NOS) and strictly euthymic. All patients had a standardized clinical and neuropsychological assessment and were categorized as high (n = 186) or low (n = 167) adherent based on their score from the Medication Adherence Rating Scale. Clinical information was collected based on a standardized interview and clinical validated scales. Neuropsychological performances were evaluated with an established standardized neuropsychological battery for bipolar disorder patients. After univariate analysis, neuropsychological and clinical predictors of low adherence were included in two age-specific stepwise multiple logistic regressions.
A smaller number of hospitalizations (OR = 0.846, p = 0.012), a shorter illness duration (OR = 0.937, p = 0.003) and higher adverse effects (OR = 1.082, p<0.001) were associated with a greater risk of low adherence in the younger patients. In the older patients, low adherence was also predicted by a smaller number of hospitalizations (OR = 0.727, p = 0.008) and higher adverse effects (OR = 1.124, p = 0.005). Interestingly poor inhibition performance was also a significant predictor of low adherence in older patients (OR = 0.924, p = 0.030).
We found an age-specific relationship between cognitive functioning and adherence in patients with BD. Poor inhibition performances predicted low adherence in older patients only. Our results highlight the need to provide age-adapted therapeutic interventions to improve adherence in patients with BD.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28873468</pmid><doi>10.1371/journal.pone.0184313</doi><tpages>e0184313</tpages><orcidid>https://orcid.org/0000-0002-5377-1488</orcidid><orcidid>https://orcid.org/0000-0002-6519-8586</orcidid><orcidid>https://orcid.org/0000-0003-1222-6050</orcidid><orcidid>https://orcid.org/0000-0002-3660-6640</orcidid><orcidid>https://orcid.org/0000-0002-1549-9604</orcidid><orcidid>https://orcid.org/0000-0001-5473-3697</orcidid><orcidid>https://orcid.org/0000-0003-0211-3298</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2017-09, Vol.12 (9), p.e0184313 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1935803219 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adhesion Adult Age Age Factors Aged Aging Analysis Biology and Life Sciences Bipolar disorder Bipolar Disorder - psychology Care and treatment Clinical psychology Cognitive ability Cognitive science Cooperation Demography Diagnosis Drugs Female Health aspects Health sciences Humans Inhibition Inhibition (psychology) Logistic Models Male Medication Adherence Medicine and Health Sciences Memory Middle Aged Neuropsychological Tests Neuropsychology Neuroscience Neurosciences Nitric-oxide synthase Patient compliance Patients Psychiatrists Psychiatry Psychotherapy Regression analysis Side effects Social Sciences Subacute care Therapeutic applications Toxicology Veil, Simone |
| title | Neuropsychological functioning, age, and medication adherence in bipolar disorder |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T01%3A10%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Neuropsychological%20functioning,%20age,%20and%20medication%20adherence%20in%20bipolar%20disorder&rft.jtitle=PloS%20one&rft.au=Corr%C3%A9ard,%20Nadia&rft.aucorp=FACE-BD%20collaborators&rft.date=2017-09-05&rft.volume=12&rft.issue=9&rft.spage=e0184313&rft.pages=e0184313-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0184313&rft_dat=%3Cgale_plos_%3EA503304383%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1935803219&rft_id=info:pmid/28873468&rft_galeid=A503304383&rft_doaj_id=oai_doaj_org_article_ab8b5982d5754f69b8c151094a44b9e0&rfr_iscdi=true |