Antiparkinsonian effects of the "Radiprodil and Tozadenant" combination in MPTP-treated marmosets

Investigate a combination of two clinically tested drugs, the NR2B antagonist Radiprodil and the A2A antagonist Tozadenant in the MPTP-treated marmoset model of Parkinson's Disease (PD). In PD, there remains a need for the development of non-dopaminergic drugs to effectively treat the motor sym...

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Veröffentlicht in:	PloS one 2017-08, Vol.12 (8), p.e0182887-e0182887
Hauptverfasser:	Michel, Anne, Nicolas, Jean-Marie, Rose, Sarah, Jackson, Michael, Colman, Peter, Briône, Willy, Sciberras, David, Muglia, Pierandrea, Scheller, Dieter K, Citron, Martin, Downey, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Animals Antiparkinson agents Antiparkinson Agents - pharmacology Benzothiazoles - pharmacology Biology and Life Sciences Callithrix Care and treatment Cocaine Complications Dihydroxyphenylalanine Dopa Dopamine Dopamine receptors Dosage and administration Drug Administration Schedule Drug Combinations Drug development Drug dosages Drug Evaluation, Preclinical Drug Synergism Drugs Dyskinesia Dyskinesia, Drug-Induced - prevention & control Female Gene Expression Kinases Levodopa Male Marmosets Medicine and Health Sciences Monkeys & apes Motor activity Motor Activity - drug effects Motor Activity - physiology Motor task performance Movement disorders MPTP MPTP Poisoning - drug therapy MPTP Poisoning - genetics MPTP Poisoning - metabolism MPTP Poisoning - physiopathology Neurodegenerative diseases Pain Parkinson disease Parkinson's disease Parkinsons disease Pharmaceutical sciences Phosphorylation Primates Rats Receptors, Adenosine A2 - genetics Receptors, Adenosine A2 - metabolism Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - genetics Receptors, N-Methyl-D-Aspartate - metabolism Research and Analysis Methods Restoration Rodents Treatment Outcome
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