Expression of LRIG proteins as possible prognostic factors in primary vaginal carcinoma
Primary vaginal carcinoma (PVC) is a rare malignancy. Established prognostic factors include tumour stage and age at diagnosis. The leucine-rich repeats and immunoglobuline-like domains (LRIG)-1 protein functions as a tumour suppressor, but less is known about the functions of LRIG2 and LRIG3. The p...
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| creator | Ranhem, Cecilia Lillsunde Larsson, Gabriella Hedman, Håkan Lindquist, David Karlsson, Mats G Hellström, Ann-Cathrin Östensson, Ellinor Sorbe, Bengt Hellman, Kristina Andersson, Sonia |
| description | Primary vaginal carcinoma (PVC) is a rare malignancy. Established prognostic factors include tumour stage and age at diagnosis. The leucine-rich repeats and immunoglobuline-like domains (LRIG)-1 protein functions as a tumour suppressor, but less is known about the functions of LRIG2 and LRIG3. The present study aimed to evaluate the expression of LRIG proteins and analyse their possible associations with clinical characteristics and survival in a cohort of PVC patients.
We used immunohistochemistry to investigate LRIG1, LRIG2, and LRIG3 expression in tumour samples from a consecutive cohort of 70 PVC patients. The association between LRIG protein expression and clinical characteristics and cancer-specific survival was investigated using univariate and multivariate analyses.
The majority of PVC patients (72%) had >50% LRIG1- and LRIG2-positive cells, and no or low LRIG3-positive cells. HPV status was significantly correlated with LRIG1 expression (p = 0.0047). Having high LRIG1 expression was significantly correlated with superior cancer-specific survival in univariate and multivariate analyses. LRIG2 and LRIG3 expression did not significantly correlate with clinical characteristics or survival.
LRIG1 expression might be of interest as a prognostic marker in PVC patients, whereas the role of LRIG2 and LRIG3 expression remains to be clarified. |
| doi_str_mv | 10.1371/journal.pone.0183816 |
| format | Article |
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We used immunohistochemistry to investigate LRIG1, LRIG2, and LRIG3 expression in tumour samples from a consecutive cohort of 70 PVC patients. The association between LRIG protein expression and clinical characteristics and cancer-specific survival was investigated using univariate and multivariate analyses.
The majority of PVC patients (72%) had >50% LRIG1- and LRIG2-positive cells, and no or low LRIG3-positive cells. HPV status was significantly correlated with LRIG1 expression (p = 0.0047). Having high LRIG1 expression was significantly correlated with superior cancer-specific survival in univariate and multivariate analyses. LRIG2 and LRIG3 expression did not significantly correlate with clinical characteristics or survival.
LRIG1 expression might be of interest as a prognostic marker in PVC patients, whereas the role of LRIG2 and LRIG3 expression remains to be clarified.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0183816</identifier><identifier>PMID: 28841699</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Age ; Aged ; Aged, 80 and over ; Biological markers ; Biology and Life Sciences ; Biomarkers ; Breast cancer ; Cancer ; Cervical cancer ; Development and progression ; Female ; Gene expression ; Genetic aspects ; Genital cancers ; Growth factors ; Histology ; Hospitals ; Human papillomavirus ; Humans ; Immunoglobulins ; Immunohistochemistry ; Kinases ; Laboratories ; Leucine ; Lung cancer ; Malignancy ; Medical prognosis ; Medicine ; Medicine and Health Sciences ; Membrane Glycoproteins - metabolism ; Middle Aged ; Patients ; Physical Sciences ; Physiological aspects ; Polyvinyl chloride ; Prognosis ; Proteins ; Research and Analysis Methods ; Squamous cell carcinoma ; Studies ; Survival ; Tumors ; Vagina ; Vaginal cancer ; Vaginal Neoplasms - metabolism ; Womens health</subject><ispartof>PloS one, 2017, Vol.12 (8), p.e0183816-e0183816</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Ranhem et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Ranhem et al 2017 Ranhem et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c735t-4baa59693ed77ed1fca773a37b5369a6703c856e9ff0b235af731ecbe284f68f3</citedby><cites>FETCH-LOGICAL-c735t-4baa59693ed77ed1fca773a37b5369a6703c856e9ff0b235af731ecbe284f68f3</cites><orcidid>0000-0003-2120-7222</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571912/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571912/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,723,776,780,860,881,2096,2915,4010,23845,27900,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28841699$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-61041$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-140970$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-335230$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:136546391$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Ranhem, Cecilia</creatorcontrib><creatorcontrib>Lillsunde Larsson, Gabriella</creatorcontrib><creatorcontrib>Hedman, Håkan</creatorcontrib><creatorcontrib>Lindquist, David</creatorcontrib><creatorcontrib>Karlsson, Mats G</creatorcontrib><creatorcontrib>Hellström, Ann-Cathrin</creatorcontrib><creatorcontrib>Östensson, Ellinor</creatorcontrib><creatorcontrib>Sorbe, Bengt</creatorcontrib><creatorcontrib>Hellman, Kristina</creatorcontrib><creatorcontrib>Andersson, Sonia</creatorcontrib><title>Expression of LRIG proteins as possible prognostic factors in primary vaginal carcinoma</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Primary vaginal carcinoma (PVC) is a rare malignancy. Established prognostic factors include tumour stage and age at diagnosis. The leucine-rich repeats and immunoglobuline-like domains (LRIG)-1 protein functions as a tumour suppressor, but less is known about the functions of LRIG2 and LRIG3. The present study aimed to evaluate the expression of LRIG proteins and analyse their possible associations with clinical characteristics and survival in a cohort of PVC patients.
We used immunohistochemistry to investigate LRIG1, LRIG2, and LRIG3 expression in tumour samples from a consecutive cohort of 70 PVC patients. The association between LRIG protein expression and clinical characteristics and cancer-specific survival was investigated using univariate and multivariate analyses.
The majority of PVC patients (72%) had >50% LRIG1- and LRIG2-positive cells, and no or low LRIG3-positive cells. HPV status was significantly correlated with LRIG1 expression (p = 0.0047). Having high LRIG1 expression was significantly correlated with superior cancer-specific survival in univariate and multivariate analyses. LRIG2 and LRIG3 expression did not significantly correlate with clinical characteristics or survival.
LRIG1 expression might be of interest as a prognostic marker in PVC patients, whereas the role of LRIG2 and LRIG3 expression remains to be clarified.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological markers</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cervical cancer</subject><subject>Development and progression</subject><subject>Female</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Genital cancers</subject><subject>Growth factors</subject><subject>Histology</subject><subject>Hospitals</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Immunohistochemistry</subject><subject>Kinases</subject><subject>Laboratories</subject><subject>Leucine</subject><subject>Lung 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of LRIG proteins as possible prognostic factors in primary vaginal carcinoma</title><author>Ranhem, Cecilia ; Lillsunde Larsson, Gabriella ; Hedman, Håkan ; Lindquist, David ; Karlsson, Mats G ; Hellström, Ann-Cathrin ; Östensson, Ellinor ; Sorbe, Bengt ; Hellman, Kristina ; Andersson, Sonia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c735t-4baa59693ed77ed1fca773a37b5369a6703c856e9ff0b235af731ecbe284f68f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological markers</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers</topic><topic>Breast cancer</topic><topic>Cancer</topic><topic>Cervical cancer</topic><topic>Development and progression</topic><topic>Female</topic><topic>Gene expression</topic><topic>Genetic aspects</topic><topic>Genital 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one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ranhem, Cecilia</au><au>Lillsunde Larsson, Gabriella</au><au>Hedman, Håkan</au><au>Lindquist, David</au><au>Karlsson, Mats G</au><au>Hellström, Ann-Cathrin</au><au>Östensson, Ellinor</au><au>Sorbe, Bengt</au><au>Hellman, Kristina</au><au>Andersson, Sonia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of LRIG proteins as possible prognostic factors in primary vaginal carcinoma</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017</date><risdate>2017</risdate><volume>12</volume><issue>8</issue><spage>e0183816</spage><epage>e0183816</epage><pages>e0183816-e0183816</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Primary vaginal carcinoma (PVC) is a rare malignancy. Established prognostic factors include tumour stage and age at diagnosis. The leucine-rich repeats and immunoglobuline-like domains (LRIG)-1 protein functions as a tumour suppressor, but less is known about the functions of LRIG2 and LRIG3. The present study aimed to evaluate the expression of LRIG proteins and analyse their possible associations with clinical characteristics and survival in a cohort of PVC patients.
We used immunohistochemistry to investigate LRIG1, LRIG2, and LRIG3 expression in tumour samples from a consecutive cohort of 70 PVC patients. The association between LRIG protein expression and clinical characteristics and cancer-specific survival was investigated using univariate and multivariate analyses.
The majority of PVC patients (72%) had >50% LRIG1- and LRIG2-positive cells, and no or low LRIG3-positive cells. HPV status was significantly correlated with LRIG1 expression (p = 0.0047). Having high LRIG1 expression was significantly correlated with superior cancer-specific survival in univariate and multivariate analyses. LRIG2 and LRIG3 expression did not significantly correlate with clinical characteristics or survival.
LRIG1 expression might be of interest as a prognostic marker in PVC patients, whereas the role of LRIG2 and LRIG3 expression remains to be clarified.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28841699</pmid><doi>10.1371/journal.pone.0183816</doi><orcidid>https://orcid.org/0000-0003-2120-7222</orcidid><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1932356393 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SWEPUB Freely available online; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adult Age Aged Aged, 80 and over Biological markers Biology and Life Sciences Biomarkers Breast cancer Cancer Cervical cancer Development and progression Female Gene expression Genetic aspects Genital cancers Growth factors Histology Hospitals Human papillomavirus Humans Immunoglobulins Immunohistochemistry Kinases Laboratories Leucine Lung cancer Malignancy Medical prognosis Medicine Medicine and Health Sciences Membrane Glycoproteins - metabolism Middle Aged Patients Physical Sciences Physiological aspects Polyvinyl chloride Prognosis Proteins Research and Analysis Methods Squamous cell carcinoma Studies Survival Tumors Vagina Vaginal cancer Vaginal Neoplasms - metabolism Womens health |
| title | Expression of LRIG proteins as possible prognostic factors in primary vaginal carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-20T11%3A52%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Expression%20of%20LRIG%20proteins%20as%20possible%20prognostic%20factors%20in%20primary%20vaginal%20carcinoma&rft.jtitle=PloS%20one&rft.au=Ranhem,%20Cecilia&rft.date=2017&rft.volume=12&rft.issue=8&rft.spage=e0183816&rft.epage=e0183816&rft.pages=e0183816-e0183816&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0183816&rft_dat=%3Cgale_plos_%3EA501792960%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1932356393&rft_id=info:pmid/28841699&rft_galeid=A501792960&rft_doaj_id=oai_doaj_org_article_d9d637b7ec124c1bbea2263e51cb875e&rfr_iscdi=true |