Leishmania infection and blood food sources of phlebotomines in an area of Brazil endemic for visceral and tegumentary leishmaniasis
The aims of the study were to determine the blood feeding preferences of sandflies and to identify species of Leishmania that infected phlebotomines in Caxias, Maranhão, Brazil, an area that is highly endemic for leishmaniasis. Sandflies were captured in light traps located in the peridomiciliary en...
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| Veröffentlicht in: | PloS one 2017-08, Vol.12 (8), p.e0179052-e0179052 |
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| description | The aims of the study were to determine the blood feeding preferences of sandflies and to identify species of Leishmania that infected phlebotomines in Caxias, Maranhão, Brazil, an area that is highly endemic for leishmaniasis. Sandflies were captured in light traps located in the peridomiciliary environments of randomly selected houses in urban and rural settings between 1800 and 0600 hours on new moon days between March 2013 and February 2015. DNA extracts from 982 engorged female sandflies were submitted to fragment length polymorphism analysis to identify infecting species of Leishmania, and blood sources were identified for 778 of these specimens. Infection by Leishmania infantum was detected in Lutzomyia longipalpis, Lu. whitmani and Lu. termitophila; L. infantum/L. braziliensis in Lu. longipalpis, Lu. whitmani and Lu. trinidadensis; L. shawi in Lu. longipalpis; L. mexicana in Lu. longipalpis; L. braziliensis in Lu. longipalpis and Lu. whitmani; L. guyanensis in Lu. longipalpis and Lu. termitophila; L. amazonensis in Lu. longipalpis and L. lainsoni or L. naiffi in Lu. longipalpis, while Lu. longipalpis and Lu. trinidadensis were infected with unidentified Leishmania sp. Blood sources were identified in 573 individual phlebotomines and the preferred hosts were, in decreasing order, chicken, dog, rodent and human with lower preferences for pig, horse, opossum and cattle. Lu. longipalpis and Lu. whitmani performed mixed feeding on man, dog and rodent, while Lu. longipalpis was the most opportunistic species, feeding on the blood of all hosts surveyed, but preferably on dog/chicken, dog/rodent and rodent/chicken. Our findings reveal the concomitant circulation of Leishmania species that cause visceral leishmaniasis and tegumentary leishmaniasis in the study area, and explain the occurrence of autochthonous human cases of both clinical forms of leishmaniasis in Caxias, Maranhão. The results support our hypothesis that, in the municipality of Caxias, transmission of Leishmania occurs in close proximity to humans. |
| doi_str_mv | 10.1371/journal.pone.0179052 |
| format | Article |
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Sandflies were captured in light traps located in the peridomiciliary environments of randomly selected houses in urban and rural settings between 1800 and 0600 hours on new moon days between March 2013 and February 2015. DNA extracts from 982 engorged female sandflies were submitted to fragment length polymorphism analysis to identify infecting species of Leishmania, and blood sources were identified for 778 of these specimens. Infection by Leishmania infantum was detected in Lutzomyia longipalpis, Lu. whitmani and Lu. termitophila; L. infantum/L. braziliensis in Lu. longipalpis, Lu. whitmani and Lu. trinidadensis; L. shawi in Lu. longipalpis; L. mexicana in Lu. longipalpis; L. braziliensis in Lu. longipalpis and Lu. whitmani; L. guyanensis in Lu. longipalpis and Lu. termitophila; L. amazonensis in Lu. longipalpis and L. lainsoni or L. naiffi in Lu. longipalpis, while Lu. longipalpis and Lu. trinidadensis were infected with unidentified Leishmania sp. Blood sources were identified in 573 individual phlebotomines and the preferred hosts were, in decreasing order, chicken, dog, rodent and human with lower preferences for pig, horse, opossum and cattle. Lu. longipalpis and Lu. whitmani performed mixed feeding on man, dog and rodent, while Lu. longipalpis was the most opportunistic species, feeding on the blood of all hosts surveyed, but preferably on dog/chicken, dog/rodent and rodent/chicken. Our findings reveal the concomitant circulation of Leishmania species that cause visceral leishmaniasis and tegumentary leishmaniasis in the study area, and explain the occurrence of autochthonous human cases of both clinical forms of leishmaniasis in Caxias, Maranhão. The results support our hypothesis that, in the municipality of Caxias, transmission of Leishmania occurs in close proximity to humans.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0179052</identifier><identifier>PMID: 28837565</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Animals ; Biology and Life Sciences ; Blood ; Brazil - epidemiology ; Chickens ; Circulation ; Deoxyribonucleic acid ; DNA ; Dogs ; Epidemiology ; Ethics ; Feeding ; Feeding Behavior ; Female ; Food sources ; Genetic polymorphisms ; Health aspects ; Housing ; Humans ; Hypotheses ; Infection ; Infections ; Insect Vectors ; Laboratory animals ; Leishmaniasis ; Leishmaniasis, Cutaneous - epidemiology ; Leishmaniasis, Visceral - epidemiology ; Light traps ; Medicine and Health Sciences ; Moon ; Parasitic diseases ; Pathogens ; Polymorphism ; Poultry housing ; Psychodidae - physiology ; Residential areas ; Rodents ; Rural environments ; Species ; Studies ; Tegumentary leishmaniasis ; Tropical diseases ; Vector-borne diseases ; Visceral leishmaniasis</subject><ispartof>PloS one, 2017-08, Vol.12 (8), p.e0179052-e0179052</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Guimarães-e-Silva et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Guimarães-e-Silva et al 2017 Guimarães-e-Silva et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-e9546a16d64dcaa5ffd43b18b487a509fe7b004bfe6737140219290ec6bc6e9e3</citedby><cites>FETCH-LOGICAL-c692t-e9546a16d64dcaa5ffd43b18b487a509fe7b004bfe6737140219290ec6bc6e9e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570267/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570267/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28837565$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guimarães-E-Silva, Antônia Suely</creatorcontrib><creatorcontrib>Silva, Soraia de Oliveira</creatorcontrib><creatorcontrib>Ribeiro da Silva, Rosa Cristina</creatorcontrib><creatorcontrib>Pinheiro, Valéria Cristina Soares</creatorcontrib><creatorcontrib>Rebêlo, José Manuel Macário</creatorcontrib><creatorcontrib>Melo, Maria Norma</creatorcontrib><title>Leishmania infection and blood food sources of phlebotomines in an area of Brazil endemic for visceral and tegumentary leishmaniasis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The aims of the study were to determine the blood feeding preferences of sandflies and to identify species of Leishmania that infected phlebotomines in Caxias, Maranhão, Brazil, an area that is highly endemic for leishmaniasis. Sandflies were captured in light traps located in the peridomiciliary environments of randomly selected houses in urban and rural settings between 1800 and 0600 hours on new moon days between March 2013 and February 2015. DNA extracts from 982 engorged female sandflies were submitted to fragment length polymorphism analysis to identify infecting species of Leishmania, and blood sources were identified for 778 of these specimens. Infection by Leishmania infantum was detected in Lutzomyia longipalpis, Lu. whitmani and Lu. termitophila; L. infantum/L. braziliensis in Lu. longipalpis, Lu. whitmani and Lu. trinidadensis; L. shawi in Lu. longipalpis; L. mexicana in Lu. longipalpis; L. braziliensis in Lu. longipalpis and Lu. whitmani; L. guyanensis in Lu. longipalpis and Lu. termitophila; L. amazonensis in Lu. longipalpis and L. lainsoni or L. naiffi in Lu. longipalpis, while Lu. longipalpis and Lu. trinidadensis were infected with unidentified Leishmania sp. 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The results support our hypothesis that, in the municipality of Caxias, transmission of Leishmania occurs in close proximity to humans.</description><subject>Analysis</subject><subject>Animals</subject><subject>Biology and Life Sciences</subject><subject>Blood</subject><subject>Brazil - epidemiology</subject><subject>Chickens</subject><subject>Circulation</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Dogs</subject><subject>Epidemiology</subject><subject>Ethics</subject><subject>Feeding</subject><subject>Feeding Behavior</subject><subject>Female</subject><subject>Food sources</subject><subject>Genetic polymorphisms</subject><subject>Health aspects</subject><subject>Housing</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Infection</subject><subject>Infections</subject><subject>Insect Vectors</subject><subject>Laboratory animals</subject><subject>Leishmaniasis</subject><subject>Leishmaniasis, Cutaneous - epidemiology</subject><subject>Leishmaniasis, Visceral - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guimarães-E-Silva, Antônia Suely</au><au>Silva, Soraia de Oliveira</au><au>Ribeiro da Silva, Rosa Cristina</au><au>Pinheiro, Valéria Cristina Soares</au><au>Rebêlo, José Manuel Macário</au><au>Melo, Maria Norma</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leishmania infection and blood food sources of phlebotomines in an area of Brazil endemic for visceral and tegumentary leishmaniasis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-08-24</date><risdate>2017</risdate><volume>12</volume><issue>8</issue><spage>e0179052</spage><epage>e0179052</epage><pages>e0179052-e0179052</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The aims of the study were to determine the blood feeding preferences of sandflies and to identify species of Leishmania that infected phlebotomines in Caxias, Maranhão, Brazil, an area that is highly endemic for leishmaniasis. Sandflies were captured in light traps located in the peridomiciliary environments of randomly selected houses in urban and rural settings between 1800 and 0600 hours on new moon days between March 2013 and February 2015. DNA extracts from 982 engorged female sandflies were submitted to fragment length polymorphism analysis to identify infecting species of Leishmania, and blood sources were identified for 778 of these specimens. Infection by Leishmania infantum was detected in Lutzomyia longipalpis, Lu. whitmani and Lu. termitophila; L. infantum/L. braziliensis in Lu. longipalpis, Lu. whitmani and Lu. trinidadensis; L. shawi in Lu. longipalpis; L. mexicana in Lu. longipalpis; L. braziliensis in Lu. longipalpis and Lu. whitmani; L. guyanensis in Lu. longipalpis and Lu. termitophila; L. amazonensis in Lu. longipalpis and L. lainsoni or L. naiffi in Lu. longipalpis, while Lu. longipalpis and Lu. trinidadensis were infected with unidentified Leishmania sp. Blood sources were identified in 573 individual phlebotomines and the preferred hosts were, in decreasing order, chicken, dog, rodent and human with lower preferences for pig, horse, opossum and cattle. Lu. longipalpis and Lu. whitmani performed mixed feeding on man, dog and rodent, while Lu. longipalpis was the most opportunistic species, feeding on the blood of all hosts surveyed, but preferably on dog/chicken, dog/rodent and rodent/chicken. Our findings reveal the concomitant circulation of Leishmania species that cause visceral leishmaniasis and tegumentary leishmaniasis in the study area, and explain the occurrence of autochthonous human cases of both clinical forms of leishmaniasis in Caxias, Maranhão. The results support our hypothesis that, in the municipality of Caxias, transmission of Leishmania occurs in close proximity to humans.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28837565</pmid><doi>10.1371/journal.pone.0179052</doi><tpages>e0179052</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2017-08, Vol.12 (8), p.e0179052-e0179052 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1932060900 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Analysis Animals Biology and Life Sciences Blood Brazil - epidemiology Chickens Circulation Deoxyribonucleic acid DNA Dogs Epidemiology Ethics Feeding Feeding Behavior Female Food sources Genetic polymorphisms Health aspects Housing Humans Hypotheses Infection Infections Insect Vectors Laboratory animals Leishmaniasis Leishmaniasis, Cutaneous - epidemiology Leishmaniasis, Visceral - epidemiology Light traps Medicine and Health Sciences Moon Parasitic diseases Pathogens Polymorphism Poultry housing Psychodidae - physiology Residential areas Rodents Rural environments Species Studies Tegumentary leishmaniasis Tropical diseases Vector-borne diseases Visceral leishmaniasis |
| title | Leishmania infection and blood food sources of phlebotomines in an area of Brazil endemic for visceral and tegumentary leishmaniasis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T22%3A53%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Leishmania%20infection%20and%20blood%20food%20sources%20of%20phlebotomines%20in%20an%20area%20of%20Brazil%20endemic%20for%20visceral%20and%20tegumentary%20leishmaniasis&rft.jtitle=PloS%20one&rft.au=Guimar%C3%A3es-E-Silva,%20Ant%C3%B4nia%20Suely&rft.date=2017-08-24&rft.volume=12&rft.issue=8&rft.spage=e0179052&rft.epage=e0179052&rft.pages=e0179052-e0179052&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0179052&rft_dat=%3Cgale_plos_%3EA501665528%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1932060900&rft_id=info:pmid/28837565&rft_galeid=A501665528&rft_doaj_id=oai_doaj_org_article_bc91636f8c3e44c9946377ae3a10d665&rfr_iscdi=true |