Persimmon-derived tannin has bacteriostatic and anti-inflammatory activity in a murine model of Mycobacterium avium complex (MAC) disease
Nontuberculous mycobacteria (NTM), including Mycobacterium avium complex (MAC), cause opportunistic chronic pulmonary infections. Notably, MAC susceptibility is regulated by various factors, including the host immune system. Persimmon (Ebenaceae Diospyros kaki Thunb.) tannin is a condensed tannin co...
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| creator | Matsumura, Yoko Kitabatake, Masahiro Ouji-Sageshima, Noriko Yasui, Satsuki Mochida, Naoko Nakano, Ryuichi Kasahara, Kei Tomoda, Koichi Yano, Hisakazu Kayano, Shin-Ichi Ito, Toshihiro |
| description | Nontuberculous mycobacteria (NTM), including Mycobacterium avium complex (MAC), cause opportunistic chronic pulmonary infections. Notably, MAC susceptibility is regulated by various factors, including the host immune system. Persimmon (Ebenaceae Diospyros kaki Thunb.) tannin is a condensed tannin composed of a polymer of catechin groups. It is well known that condensed tannins have high antioxidant activity and bacteriostatic properties. However, it is hypothesized that condensed tannins might need to be digested and/or fermented into smaller molecules in vivo prior to being absorbed into the body to perform beneficial functions. In this study, we evaluated the effects of soluble persimmon-derived tannins on opportunistic MAC disease. Soluble tannins were hydrolyzed and evaluated by the oxygen radical absorbance capacity (ORAC) method. The ORAC value of soluble tannin hydrolysate was approximately five times greater than that of soluble tannin powder. In addition, soluble tannin hydrolysate exhibited high bacteriostatic activity against MAC in vitro. Furthermore, in an in vivo study, MAC infected mice fed a soluble tannin-containing diet showed significantly higher anti-bacterial activity against MAC and less pulmonary granuloma formation compared with those fed a control diet. Tumor necrosis factor α and inducible nitric oxide synthase levels were significantly lower in lungs of the soluble tannin diet group compared with the control diet group. Moreover, proinflammatory cytokines induced by MAC stimulation of bone marrow-derived macrophages were significantly decreased by addition of soluble tannin hydrolysate. These data suggest that soluble tannin from persimmons might attenuate the pathogenesis of pulmonary NTM infection. |
| doi_str_mv | 10.1371/journal.pone.0183489 |
| format | Article |
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Notably, MAC susceptibility is regulated by various factors, including the host immune system. Persimmon (Ebenaceae Diospyros kaki Thunb.) tannin is a condensed tannin composed of a polymer of catechin groups. It is well known that condensed tannins have high antioxidant activity and bacteriostatic properties. However, it is hypothesized that condensed tannins might need to be digested and/or fermented into smaller molecules in vivo prior to being absorbed into the body to perform beneficial functions. In this study, we evaluated the effects of soluble persimmon-derived tannins on opportunistic MAC disease. Soluble tannins were hydrolyzed and evaluated by the oxygen radical absorbance capacity (ORAC) method. The ORAC value of soluble tannin hydrolysate was approximately five times greater than that of soluble tannin powder. In addition, soluble tannin hydrolysate exhibited high bacteriostatic activity against MAC in vitro. Furthermore, in an in vivo study, MAC infected mice fed a soluble tannin-containing diet showed significantly higher anti-bacterial activity against MAC and less pulmonary granuloma formation compared with those fed a control diet. Tumor necrosis factor α and inducible nitric oxide synthase levels were significantly lower in lungs of the soluble tannin diet group compared with the control diet group. Moreover, proinflammatory cytokines induced by MAC stimulation of bone marrow-derived macrophages were significantly decreased by addition of soluble tannin hydrolysate. These data suggest that soluble tannin from persimmons might attenuate the pathogenesis of pulmonary NTM infection.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0183489</identifier><identifier>PMID: 28827842</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Absorbance ; Animal models ; Animals ; Anti-Bacterial Agents - therapeutic use ; Anti-inflammatory agents ; Antioxidants ; Bacteria ; Bacteriostats ; Biology and Life Sciences ; Bone marrow ; Care and treatment ; Catechin ; Cytokines ; Diet ; Diospyros - chemistry ; Diospyros kaki ; Disease Models, Animal ; Female ; Fermented food ; Fruits ; Genetic aspects ; Granuloma ; Granulomas ; Health aspects ; Hydrologic data ; Immune system ; Immunology ; In vitro methods and tests ; In vivo methods and tests ; Infections ; Infectious diseases ; Inflammation ; Inflammation - drug therapy ; Lungs ; Macrophages ; Medicine and Health Sciences ; Mice ; Mice, Inbred BALB C ; Mycobacterium avium complex ; Mycobacterium avium-intracellulare Infection - drug therapy ; Nitric oxide ; Nitric-oxide synthase ; Nutrition ; Oxygen ; Pathogenesis ; Persimmons ; Physiological aspects ; Polymers ; Powder ; Research and analysis methods ; Rodents ; Stimulation ; Studies ; Tannic acid ; Tannins ; Tannins - therapeutic use ; Tumor necrosis factor-TNF</subject><ispartof>PloS one, 2017-08, Vol.12 (8), p.e0183489-e0183489</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Matsumura et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Matsumura et al 2017 Matsumura et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c732t-f79bf62268e9e41d62b96bb32b407ae867bd2b28446197734d81e276eb664e423</citedby><cites>FETCH-LOGICAL-c732t-f79bf62268e9e41d62b96bb32b407ae867bd2b28446197734d81e276eb664e423</cites><orcidid>0000-0003-1728-2449</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565117/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565117/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23865,27923,27924,53790,53792,79371,79372</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28827842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bach, Horacio</contributor><creatorcontrib>Matsumura, Yoko</creatorcontrib><creatorcontrib>Kitabatake, Masahiro</creatorcontrib><creatorcontrib>Ouji-Sageshima, Noriko</creatorcontrib><creatorcontrib>Yasui, Satsuki</creatorcontrib><creatorcontrib>Mochida, Naoko</creatorcontrib><creatorcontrib>Nakano, Ryuichi</creatorcontrib><creatorcontrib>Kasahara, Kei</creatorcontrib><creatorcontrib>Tomoda, Koichi</creatorcontrib><creatorcontrib>Yano, Hisakazu</creatorcontrib><creatorcontrib>Kayano, Shin-Ichi</creatorcontrib><creatorcontrib>Ito, Toshihiro</creatorcontrib><title>Persimmon-derived tannin has bacteriostatic and anti-inflammatory activity in a murine model of Mycobacterium avium complex (MAC) disease</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Nontuberculous mycobacteria (NTM), including Mycobacterium avium complex (MAC), cause opportunistic chronic pulmonary infections. Notably, MAC susceptibility is regulated by various factors, including the host immune system. Persimmon (Ebenaceae Diospyros kaki Thunb.) tannin is a condensed tannin composed of a polymer of catechin groups. It is well known that condensed tannins have high antioxidant activity and bacteriostatic properties. However, it is hypothesized that condensed tannins might need to be digested and/or fermented into smaller molecules in vivo prior to being absorbed into the body to perform beneficial functions. In this study, we evaluated the effects of soluble persimmon-derived tannins on opportunistic MAC disease. Soluble tannins were hydrolyzed and evaluated by the oxygen radical absorbance capacity (ORAC) method. The ORAC value of soluble tannin hydrolysate was approximately five times greater than that of soluble tannin powder. In addition, soluble tannin hydrolysate exhibited high bacteriostatic activity against MAC in vitro. Furthermore, in an in vivo study, MAC infected mice fed a soluble tannin-containing diet showed significantly higher anti-bacterial activity against MAC and less pulmonary granuloma formation compared with those fed a control diet. Tumor necrosis factor α and inducible nitric oxide synthase levels were significantly lower in lungs of the soluble tannin diet group compared with the control diet group. Moreover, proinflammatory cytokines induced by MAC stimulation of bone marrow-derived macrophages were significantly decreased by addition of soluble tannin hydrolysate. These data suggest that soluble tannin from persimmons might attenuate the pathogenesis of pulmonary NTM infection.</description><subject>Absorbance</subject><subject>Animal models</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Anti-inflammatory agents</subject><subject>Antioxidants</subject><subject>Bacteria</subject><subject>Bacteriostats</subject><subject>Biology and Life Sciences</subject><subject>Bone marrow</subject><subject>Care and treatment</subject><subject>Catechin</subject><subject>Cytokines</subject><subject>Diet</subject><subject>Diospyros - chemistry</subject><subject>Diospyros kaki</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Fermented food</subject><subject>Fruits</subject><subject>Genetic aspects</subject><subject>Granuloma</subject><subject>Granulomas</subject><subject>Health aspects</subject><subject>Hydrologic data</subject><subject>Immune system</subject><subject>Immunology</subject><subject>In vitro methods and tests</subject><subject>In vivo methods and tests</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Inflammation</subject><subject>Inflammation - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsumura, Yoko</au><au>Kitabatake, Masahiro</au><au>Ouji-Sageshima, Noriko</au><au>Yasui, Satsuki</au><au>Mochida, Naoko</au><au>Nakano, Ryuichi</au><au>Kasahara, Kei</au><au>Tomoda, Koichi</au><au>Yano, Hisakazu</au><au>Kayano, Shin-Ichi</au><au>Ito, Toshihiro</au><au>Bach, Horacio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Persimmon-derived tannin has bacteriostatic and anti-inflammatory activity in a murine model of Mycobacterium avium complex (MAC) disease</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-08-21</date><risdate>2017</risdate><volume>12</volume><issue>8</issue><spage>e0183489</spage><epage>e0183489</epage><pages>e0183489-e0183489</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Nontuberculous mycobacteria (NTM), including Mycobacterium avium complex (MAC), cause opportunistic chronic pulmonary infections. Notably, MAC susceptibility is regulated by various factors, including the host immune system. Persimmon (Ebenaceae Diospyros kaki Thunb.) tannin is a condensed tannin composed of a polymer of catechin groups. It is well known that condensed tannins have high antioxidant activity and bacteriostatic properties. However, it is hypothesized that condensed tannins might need to be digested and/or fermented into smaller molecules in vivo prior to being absorbed into the body to perform beneficial functions. In this study, we evaluated the effects of soluble persimmon-derived tannins on opportunistic MAC disease. Soluble tannins were hydrolyzed and evaluated by the oxygen radical absorbance capacity (ORAC) method. The ORAC value of soluble tannin hydrolysate was approximately five times greater than that of soluble tannin powder. In addition, soluble tannin hydrolysate exhibited high bacteriostatic activity against MAC in vitro. Furthermore, in an in vivo study, MAC infected mice fed a soluble tannin-containing diet showed significantly higher anti-bacterial activity against MAC and less pulmonary granuloma formation compared with those fed a control diet. Tumor necrosis factor α and inducible nitric oxide synthase levels were significantly lower in lungs of the soluble tannin diet group compared with the control diet group. Moreover, proinflammatory cytokines induced by MAC stimulation of bone marrow-derived macrophages were significantly decreased by addition of soluble tannin hydrolysate. These data suggest that soluble tannin from persimmons might attenuate the pathogenesis of pulmonary NTM infection.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28827842</pmid><doi>10.1371/journal.pone.0183489</doi><orcidid>https://orcid.org/0000-0003-1728-2449</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2017-08, Vol.12 (8), p.e0183489-e0183489 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1930844199 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Absorbance Animal models Animals Anti-Bacterial Agents - therapeutic use Anti-inflammatory agents Antioxidants Bacteria Bacteriostats Biology and Life Sciences Bone marrow Care and treatment Catechin Cytokines Diet Diospyros - chemistry Diospyros kaki Disease Models, Animal Female Fermented food Fruits Genetic aspects Granuloma Granulomas Health aspects Hydrologic data Immune system Immunology In vitro methods and tests In vivo methods and tests Infections Infectious diseases Inflammation Inflammation - drug therapy Lungs Macrophages Medicine and Health Sciences Mice Mice, Inbred BALB C Mycobacterium avium complex Mycobacterium avium-intracellulare Infection - drug therapy Nitric oxide Nitric-oxide synthase Nutrition Oxygen Pathogenesis Persimmons Physiological aspects Polymers Powder Research and analysis methods Rodents Stimulation Studies Tannic acid Tannins Tannins - therapeutic use Tumor necrosis factor-TNF |
| title | Persimmon-derived tannin has bacteriostatic and anti-inflammatory activity in a murine model of Mycobacterium avium complex (MAC) disease |
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