Dextran sodium sulfate (DSS) induces necrotizing enterocolitis-like lesions in neonatal mice

Necrotizing enterocolitis (NEC) is an inflammatory bowel disease of preterm human newborns with yet unresolved etiology. An established neonatal murine model for NEC employs oral administration of lipopolysaccharides (LPS) combined with hypoxia/hypothermia. In adult mice, feeding dextran sodium sulf...

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Veröffentlicht in:	PloS one 2017-08, Vol.12 (8), p.e0182732-e0182732
Hauptverfasser:	Ginzel, Marco, Feng, Xiaoyan, Kuebler, Joachim F, Klemann, Christian, Yu, Yi, von Wasielewski, Reinhard, Park, Joon-Keun, Hornef, Mathias W, Vieten, Gertrud, Ure, Benno M, Kaussen, Torsten, Gosemann, Jan Hendrik, Mayer, Steffi, Suttkus, Anne, Lacher, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal models Animals Animals, Newborn Apoptosis Biology and Life Sciences Colon Comparative analysis Cytometry Development and progression Dextran Dextran Sulfate - toxicity Dextrans Disease Models, Animal Drinking water Enterocolitis Enterocolitis, Necrotizing - etiology Enterocolitis, Necrotizing - pathology Etiology Feeding Flow cytometry Gangrene Gastroenterology Gastrointestinal diseases Gene expression Histology Hypothermia Hypoxia Immune response Immune response (cell-mediated) Immune response (humoral) Immune system Immunology Infiltration Inflammation Inflammatory bowel disease Inflammatory bowel diseases Intestinal Mucosa - drug effects Large intestine Lesions Lipopolysaccharides Macrophages Macrophages - pathology Medical research Medical schools Medicine and Health Sciences Mice Mice, Inbred C57BL Monocytes Necrosis Necrotizing enterocolitis Neonates Neutrophil Infiltration Neutrophils Newborn babies Oral administration Pathogenesis Pediatrics Physical stress Physiological aspects Physiology Polymerase chain reaction Recruitment Research and Analysis Methods Risk factors Rodents Small intestine Sodium Sodium sulfate Sulfates Surgery
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