Family-based exome-wide association study of childhood acute lymphoblastic leukemia among Hispanics confirms role of ARID5B in susceptibility

We conducted an exome-wide association study of childhood acute lymphoblastic leukemia (ALL) among Hispanics to confirm and identify novel variants associated with disease risk in this population. We used a case-parent trio study design; unlike more commonly used case-control studies, this study des...

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Veröffentlicht in:	PloS one 2017-08, Vol.12 (8), p.e0180488
Hauptverfasser:	Archer, Natalie P, Perez-Andreu, Virginia, Stoltze, Ulrik, Scheurer, Michael E, Wilkinson, Anna V, Lin, Ting-Nien, Qian, Maoxiang, Goodings, Charnise, Swartz, Michael D, Ranjit, Nalini, Rabin, Karen R, Peckham-Gregory, Erin C, Plon, Sharon E, de Alarcon, Pedro A, Zabriskie, Ryan C, Antillon-Klussmann, Federico, Najera, Cesar R, Yang, Jun J, Lupo, Philip J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia Acute lymphocytic leukemia Adolescent Alleles Analysis Bias Bioinformatics Biology and Life Sciences Cancer Care and treatment Child Child, Preschool Childhood Children Children & youth College campuses DNA-Binding Proteins - genetics Ethnicity Exome Families & family life Female Genetic Association Studies Genetic Predisposition to Disease Genome-wide association studies Genome-Wide Association Study Genomes Genotype Guatemala Health aspects Health care Health risks Hematology Hispanic Americans Hispanic Americans - genetics Hospitals Humans Infant Infant, Newborn Leukemia Lymphatic leukemia Male Medicine Medicine and Health Sciences Minority & ethnic groups Oncology Pediatrics People and Places Pharmaceutical sciences Polymorphism, Single Nucleotide Population Population genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Public health Single-nucleotide polymorphism Texas Transcription Factors - genetics
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