Family-based exome-wide association study of childhood acute lymphoblastic leukemia among Hispanics confirms role of ARID5B in susceptibility
We conducted an exome-wide association study of childhood acute lymphoblastic leukemia (ALL) among Hispanics to confirm and identify novel variants associated with disease risk in this population. We used a case-parent trio study design; unlike more commonly used case-control studies, this study des...
Gespeichert in:
| Veröffentlicht in: | PloS one 2017-08, Vol.12 (8), p.e0180488 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 8 |
| container_start_page | e0180488 |
| container_title | PloS one |
| container_volume | 12 |
| creator | Archer, Natalie P Perez-Andreu, Virginia Stoltze, Ulrik Scheurer, Michael E Wilkinson, Anna V Lin, Ting-Nien Qian, Maoxiang Goodings, Charnise Swartz, Michael D Ranjit, Nalini Rabin, Karen R Peckham-Gregory, Erin C Plon, Sharon E de Alarcon, Pedro A Zabriskie, Ryan C Antillon-Klussmann, Federico Najera, Cesar R Yang, Jun J Lupo, Philip J |
| description | We conducted an exome-wide association study of childhood acute lymphoblastic leukemia (ALL) among Hispanics to confirm and identify novel variants associated with disease risk in this population. We used a case-parent trio study design; unlike more commonly used case-control studies, this study design is ideal for avoiding issues with population stratification bias among this at-risk ethnic group. Using 710 individuals from 323 Guatemalan and US Hispanic families, two inherited SNPs in ARID5B reached genome-wide level significance: rs10821936, RR = 2.31, 95% CI = 1.70-3.14, p = 1.7×10-8 and rs7089424, RR = 2.22, 95% CI = 1.64-3.01, p = 5.2×10-8. Similar results were observed when restricting our analyses to those with the B-ALL subtype: ARID5B rs10821936 RR = 2.22, 95% CI = 1.63-3.02, p = 9.63×10-8 and ARID5B rs7089424 RR = 2.13, 95% CI = 1.57-2.88, p = 2.81×10-7. Notably, effect sizes observed for rs7089424 and rs10821936 in our study were >20% higher than those reported among non-Hispanic white populations in previous genetic association studies. Our results confirmed the role of ARID5B in childhood ALL susceptibility among Hispanics; however, our assessment did not reveal any strong novel inherited genetic risks for acute lymphoblastic leukemia among this ethnic group. |
| doi_str_mv | 10.1371/journal.pone.0180488 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1930442016</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A501760023</galeid><doaj_id>oai_doaj_org_article_66ee2b0dd9024e2a833cc9b23e7f6b6b</doaj_id><sourcerecordid>A501760023</sourcerecordid><originalsourceid>FETCH-LOGICAL-c659t-aeb283581185ab703be47f5ecbcd542f877e4dad9c24715770f7a863fc34d8853</originalsourceid><addsrcrecordid>eNqNk9-K1DAUxoso7rr6BqIBQfCiY5q0TeZmYVxdd2BhYf1zG9LkdJo1bWqT6s5D-M5mnO4yBQXJRcLJ73xJvpOTJM8zvMgoy97euHHopF30roMFzjjOOX-QHGdLStKSYPrwYH2UPPH-BuOC8rJ8nBwRzjNWMn6c_DqXrbHbtJIeNIJb10L602hA0nunjAzGdciHUW-Rq5FqjNWNcxpJNQZAdtv2jaus9MEoZGH8Bq2RSLau26AL43vZGeWRcl1thtajwVnY6ayu1--Ld8hE6dEr6IOpjDVh-zR5VEvr4dk0nyRfzj98PrtIL68-rs9Wl6kqi2VIJVSE04JnGS9kxTCtIGd1AapSushJzRmDXEu9VCRnWcEYrpnkJa0VzTXnBT1JXu51e-u8mJz0IvqF85zgrIzEek9oJ29EP5hWDlvhpBF_Am7YCDnER1sQZQlAKqz1EpMciOSUKrWsCAVWl1VZRa3T6bSxakEr6MIg7Ux0vtOZRmzcD1EUJWY4jwKvJoHBfR_Bh39ceaI2Mt7KdLWLYqo1XolVgWO9MSY0Uou_UHHoWLpYKKhNjM8S3swSIhPgNmzk6L1Yf7r-f_bq65x9fcA2IG1ovLPj7sf5OZjvQTU47weo753LsNi1wp0bYtcKYmqFmPbi0PX7pLu_T38DHkgGbQ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1930442016</pqid></control><display><type>article</type><title>Family-based exome-wide association study of childhood acute lymphoblastic leukemia among Hispanics confirms role of ARID5B in susceptibility</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Archer, Natalie P ; Perez-Andreu, Virginia ; Stoltze, Ulrik ; Scheurer, Michael E ; Wilkinson, Anna V ; Lin, Ting-Nien ; Qian, Maoxiang ; Goodings, Charnise ; Swartz, Michael D ; Ranjit, Nalini ; Rabin, Karen R ; Peckham-Gregory, Erin C ; Plon, Sharon E ; de Alarcon, Pedro A ; Zabriskie, Ryan C ; Antillon-Klussmann, Federico ; Najera, Cesar R ; Yang, Jun J ; Lupo, Philip J</creator><creatorcontrib>Archer, Natalie P ; Perez-Andreu, Virginia ; Stoltze, Ulrik ; Scheurer, Michael E ; Wilkinson, Anna V ; Lin, Ting-Nien ; Qian, Maoxiang ; Goodings, Charnise ; Swartz, Michael D ; Ranjit, Nalini ; Rabin, Karen R ; Peckham-Gregory, Erin C ; Plon, Sharon E ; de Alarcon, Pedro A ; Zabriskie, Ryan C ; Antillon-Klussmann, Federico ; Najera, Cesar R ; Yang, Jun J ; Lupo, Philip J</creatorcontrib><description>We conducted an exome-wide association study of childhood acute lymphoblastic leukemia (ALL) among Hispanics to confirm and identify novel variants associated with disease risk in this population. We used a case-parent trio study design; unlike more commonly used case-control studies, this study design is ideal for avoiding issues with population stratification bias among this at-risk ethnic group. Using 710 individuals from 323 Guatemalan and US Hispanic families, two inherited SNPs in ARID5B reached genome-wide level significance: rs10821936, RR = 2.31, 95% CI = 1.70-3.14, p = 1.7×10-8 and rs7089424, RR = 2.22, 95% CI = 1.64-3.01, p = 5.2×10-8. Similar results were observed when restricting our analyses to those with the B-ALL subtype: ARID5B rs10821936 RR = 2.22, 95% CI = 1.63-3.02, p = 9.63×10-8 and ARID5B rs7089424 RR = 2.13, 95% CI = 1.57-2.88, p = 2.81×10-7. Notably, effect sizes observed for rs7089424 and rs10821936 in our study were >20% higher than those reported among non-Hispanic white populations in previous genetic association studies. Our results confirmed the role of ARID5B in childhood ALL susceptibility among Hispanics; however, our assessment did not reveal any strong novel inherited genetic risks for acute lymphoblastic leukemia among this ethnic group.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0180488</identifier><identifier>PMID: 28817678</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acute lymphoblastic leukemia ; Acute lymphocytic leukemia ; Adolescent ; Alleles ; Analysis ; Bias ; Bioinformatics ; Biology and Life Sciences ; Cancer ; Care and treatment ; Child ; Child, Preschool ; Childhood ; Children ; Children & youth ; College campuses ; DNA-Binding Proteins - genetics ; Ethnicity ; Exome ; Families & family life ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genome-wide association studies ; Genome-Wide Association Study ; Genomes ; Genotype ; Guatemala ; Health aspects ; Health care ; Health risks ; Hematology ; Hispanic Americans ; Hispanic Americans - genetics ; Hospitals ; Humans ; Infant ; Infant, Newborn ; Leukemia ; Lymphatic leukemia ; Male ; Medicine ; Medicine and Health Sciences ; Minority & ethnic groups ; Oncology ; Pediatrics ; People and Places ; Pharmaceutical sciences ; Polymorphism, Single Nucleotide ; Population ; Population genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics ; Public health ; Single-nucleotide polymorphism ; Texas ; Transcription Factors - genetics</subject><ispartof>PloS one, 2017-08, Vol.12 (8), p.e0180488</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Archer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Archer et al 2017 Archer et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c659t-aeb283581185ab703be47f5ecbcd542f877e4dad9c24715770f7a863fc34d8853</citedby><cites>FETCH-LOGICAL-c659t-aeb283581185ab703be47f5ecbcd542f877e4dad9c24715770f7a863fc34d8853</cites><orcidid>0000-0003-0978-5863</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560704/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560704/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28817678$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Archer, Natalie P</creatorcontrib><creatorcontrib>Perez-Andreu, Virginia</creatorcontrib><creatorcontrib>Stoltze, Ulrik</creatorcontrib><creatorcontrib>Scheurer, Michael E</creatorcontrib><creatorcontrib>Wilkinson, Anna V</creatorcontrib><creatorcontrib>Lin, Ting-Nien</creatorcontrib><creatorcontrib>Qian, Maoxiang</creatorcontrib><creatorcontrib>Goodings, Charnise</creatorcontrib><creatorcontrib>Swartz, Michael D</creatorcontrib><creatorcontrib>Ranjit, Nalini</creatorcontrib><creatorcontrib>Rabin, Karen R</creatorcontrib><creatorcontrib>Peckham-Gregory, Erin C</creatorcontrib><creatorcontrib>Plon, Sharon E</creatorcontrib><creatorcontrib>de Alarcon, Pedro A</creatorcontrib><creatorcontrib>Zabriskie, Ryan C</creatorcontrib><creatorcontrib>Antillon-Klussmann, Federico</creatorcontrib><creatorcontrib>Najera, Cesar R</creatorcontrib><creatorcontrib>Yang, Jun J</creatorcontrib><creatorcontrib>Lupo, Philip J</creatorcontrib><title>Family-based exome-wide association study of childhood acute lymphoblastic leukemia among Hispanics confirms role of ARID5B in susceptibility</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>We conducted an exome-wide association study of childhood acute lymphoblastic leukemia (ALL) among Hispanics to confirm and identify novel variants associated with disease risk in this population. We used a case-parent trio study design; unlike more commonly used case-control studies, this study design is ideal for avoiding issues with population stratification bias among this at-risk ethnic group. Using 710 individuals from 323 Guatemalan and US Hispanic families, two inherited SNPs in ARID5B reached genome-wide level significance: rs10821936, RR = 2.31, 95% CI = 1.70-3.14, p = 1.7×10-8 and rs7089424, RR = 2.22, 95% CI = 1.64-3.01, p = 5.2×10-8. Similar results were observed when restricting our analyses to those with the B-ALL subtype: ARID5B rs10821936 RR = 2.22, 95% CI = 1.63-3.02, p = 9.63×10-8 and ARID5B rs7089424 RR = 2.13, 95% CI = 1.57-2.88, p = 2.81×10-7. Notably, effect sizes observed for rs7089424 and rs10821936 in our study were >20% higher than those reported among non-Hispanic white populations in previous genetic association studies. Our results confirmed the role of ARID5B in childhood ALL susceptibility among Hispanics; however, our assessment did not reveal any strong novel inherited genetic risks for acute lymphoblastic leukemia among this ethnic group.</description><subject>Acute lymphoblastic leukemia</subject><subject>Acute lymphocytic leukemia</subject><subject>Adolescent</subject><subject>Alleles</subject><subject>Analysis</subject><subject>Bias</subject><subject>Bioinformatics</subject><subject>Biology and Life Sciences</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Childhood</subject><subject>Children</subject><subject>Children & youth</subject><subject>College campuses</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Ethnicity</subject><subject>Exome</subject><subject>Families & family life</subject><subject>Female</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Genome-wide association studies</subject><subject>Genome-Wide Association Study</subject><subject>Genomes</subject><subject>Genotype</subject><subject>Guatemala</subject><subject>Health aspects</subject><subject>Health care</subject><subject>Health risks</subject><subject>Hematology</subject><subject>Hispanic Americans</subject><subject>Hispanic Americans - genetics</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Leukemia</subject><subject>Lymphatic leukemia</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Minority & ethnic groups</subject><subject>Oncology</subject><subject>Pediatrics</subject><subject>People and Places</subject><subject>Pharmaceutical sciences</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population</subject><subject>Population genetics</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics</subject><subject>Public health</subject><subject>Single-nucleotide polymorphism</subject><subject>Texas</subject><subject>Transcription Factors - genetics</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9-K1DAUxoso7rr6BqIBQfCiY5q0TeZmYVxdd2BhYf1zG9LkdJo1bWqT6s5D-M5mnO4yBQXJRcLJ73xJvpOTJM8zvMgoy97euHHopF30roMFzjjOOX-QHGdLStKSYPrwYH2UPPH-BuOC8rJ8nBwRzjNWMn6c_DqXrbHbtJIeNIJb10L602hA0nunjAzGdciHUW-Rq5FqjNWNcxpJNQZAdtv2jaus9MEoZGH8Bq2RSLau26AL43vZGeWRcl1thtajwVnY6ayu1--Ld8hE6dEr6IOpjDVh-zR5VEvr4dk0nyRfzj98PrtIL68-rs9Wl6kqi2VIJVSE04JnGS9kxTCtIGd1AapSushJzRmDXEu9VCRnWcEYrpnkJa0VzTXnBT1JXu51e-u8mJz0IvqF85zgrIzEek9oJ29EP5hWDlvhpBF_Am7YCDnER1sQZQlAKqz1EpMciOSUKrWsCAVWl1VZRa3T6bSxakEr6MIg7Ux0vtOZRmzcD1EUJWY4jwKvJoHBfR_Bh39ceaI2Mt7KdLWLYqo1XolVgWO9MSY0Uou_UHHoWLpYKKhNjM8S3swSIhPgNmzk6L1Yf7r-f_bq65x9fcA2IG1ovLPj7sf5OZjvQTU47weo753LsNi1wp0bYtcKYmqFmPbi0PX7pLu_T38DHkgGbQ</recordid><startdate>20170817</startdate><enddate>20170817</enddate><creator>Archer, Natalie P</creator><creator>Perez-Andreu, Virginia</creator><creator>Stoltze, Ulrik</creator><creator>Scheurer, Michael E</creator><creator>Wilkinson, Anna V</creator><creator>Lin, Ting-Nien</creator><creator>Qian, Maoxiang</creator><creator>Goodings, Charnise</creator><creator>Swartz, Michael D</creator><creator>Ranjit, Nalini</creator><creator>Rabin, Karen R</creator><creator>Peckham-Gregory, Erin C</creator><creator>Plon, Sharon E</creator><creator>de Alarcon, Pedro A</creator><creator>Zabriskie, Ryan C</creator><creator>Antillon-Klussmann, Federico</creator><creator>Najera, Cesar R</creator><creator>Yang, Jun J</creator><creator>Lupo, Philip J</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-0978-5863</orcidid></search><sort><creationdate>20170817</creationdate><title>Family-based exome-wide association study of childhood acute lymphoblastic leukemia among Hispanics confirms role of ARID5B in susceptibility</title><author>Archer, Natalie P ; Perez-Andreu, Virginia ; Stoltze, Ulrik ; Scheurer, Michael E ; Wilkinson, Anna V ; Lin, Ting-Nien ; Qian, Maoxiang ; Goodings, Charnise ; Swartz, Michael D ; Ranjit, Nalini ; Rabin, Karen R ; Peckham-Gregory, Erin C ; Plon, Sharon E ; de Alarcon, Pedro A ; Zabriskie, Ryan C ; Antillon-Klussmann, Federico ; Najera, Cesar R ; Yang, Jun J ; Lupo, Philip J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c659t-aeb283581185ab703be47f5ecbcd542f877e4dad9c24715770f7a863fc34d8853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acute lymphoblastic leukemia</topic><topic>Acute lymphocytic leukemia</topic><topic>Adolescent</topic><topic>Alleles</topic><topic>Analysis</topic><topic>Bias</topic><topic>Bioinformatics</topic><topic>Biology and Life Sciences</topic><topic>Cancer</topic><topic>Care and treatment</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Childhood</topic><topic>Children</topic><topic>Children & youth</topic><topic>College campuses</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Ethnicity</topic><topic>Exome</topic><topic>Families & family life</topic><topic>Female</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Genome-wide association studies</topic><topic>Genome-Wide Association Study</topic><topic>Genomes</topic><topic>Genotype</topic><topic>Guatemala</topic><topic>Health aspects</topic><topic>Health care</topic><topic>Health risks</topic><topic>Hematology</topic><topic>Hispanic Americans</topic><topic>Hispanic Americans - genetics</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Leukemia</topic><topic>Lymphatic leukemia</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Minority & ethnic groups</topic><topic>Oncology</topic><topic>Pediatrics</topic><topic>People and Places</topic><topic>Pharmaceutical sciences</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Population</topic><topic>Population genetics</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics</topic><topic>Public health</topic><topic>Single-nucleotide polymorphism</topic><topic>Texas</topic><topic>Transcription Factors - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Archer, Natalie P</creatorcontrib><creatorcontrib>Perez-Andreu, Virginia</creatorcontrib><creatorcontrib>Stoltze, Ulrik</creatorcontrib><creatorcontrib>Scheurer, Michael E</creatorcontrib><creatorcontrib>Wilkinson, Anna V</creatorcontrib><creatorcontrib>Lin, Ting-Nien</creatorcontrib><creatorcontrib>Qian, Maoxiang</creatorcontrib><creatorcontrib>Goodings, Charnise</creatorcontrib><creatorcontrib>Swartz, Michael D</creatorcontrib><creatorcontrib>Ranjit, Nalini</creatorcontrib><creatorcontrib>Rabin, Karen R</creatorcontrib><creatorcontrib>Peckham-Gregory, Erin C</creatorcontrib><creatorcontrib>Plon, Sharon E</creatorcontrib><creatorcontrib>de Alarcon, Pedro A</creatorcontrib><creatorcontrib>Zabriskie, Ryan C</creatorcontrib><creatorcontrib>Antillon-Klussmann, Federico</creatorcontrib><creatorcontrib>Najera, Cesar R</creatorcontrib><creatorcontrib>Yang, Jun J</creatorcontrib><creatorcontrib>Lupo, Philip J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Archer, Natalie P</au><au>Perez-Andreu, Virginia</au><au>Stoltze, Ulrik</au><au>Scheurer, Michael E</au><au>Wilkinson, Anna V</au><au>Lin, Ting-Nien</au><au>Qian, Maoxiang</au><au>Goodings, Charnise</au><au>Swartz, Michael D</au><au>Ranjit, Nalini</au><au>Rabin, Karen R</au><au>Peckham-Gregory, Erin C</au><au>Plon, Sharon E</au><au>de Alarcon, Pedro A</au><au>Zabriskie, Ryan C</au><au>Antillon-Klussmann, Federico</au><au>Najera, Cesar R</au><au>Yang, Jun J</au><au>Lupo, Philip J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Family-based exome-wide association study of childhood acute lymphoblastic leukemia among Hispanics confirms role of ARID5B in susceptibility</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-08-17</date><risdate>2017</risdate><volume>12</volume><issue>8</issue><spage>e0180488</spage><pages>e0180488-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>We conducted an exome-wide association study of childhood acute lymphoblastic leukemia (ALL) among Hispanics to confirm and identify novel variants associated with disease risk in this population. We used a case-parent trio study design; unlike more commonly used case-control studies, this study design is ideal for avoiding issues with population stratification bias among this at-risk ethnic group. Using 710 individuals from 323 Guatemalan and US Hispanic families, two inherited SNPs in ARID5B reached genome-wide level significance: rs10821936, RR = 2.31, 95% CI = 1.70-3.14, p = 1.7×10-8 and rs7089424, RR = 2.22, 95% CI = 1.64-3.01, p = 5.2×10-8. Similar results were observed when restricting our analyses to those with the B-ALL subtype: ARID5B rs10821936 RR = 2.22, 95% CI = 1.63-3.02, p = 9.63×10-8 and ARID5B rs7089424 RR = 2.13, 95% CI = 1.57-2.88, p = 2.81×10-7. Notably, effect sizes observed for rs7089424 and rs10821936 in our study were >20% higher than those reported among non-Hispanic white populations in previous genetic association studies. Our results confirmed the role of ARID5B in childhood ALL susceptibility among Hispanics; however, our assessment did not reveal any strong novel inherited genetic risks for acute lymphoblastic leukemia among this ethnic group.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28817678</pmid><doi>10.1371/journal.pone.0180488</doi><tpages>e0180488</tpages><orcidid>https://orcid.org/0000-0003-0978-5863</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2017-08, Vol.12 (8), p.e0180488 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1930442016 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Acute lymphoblastic leukemia Acute lymphocytic leukemia Adolescent Alleles Analysis Bias Bioinformatics Biology and Life Sciences Cancer Care and treatment Child Child, Preschool Childhood Children Children & youth College campuses DNA-Binding Proteins - genetics Ethnicity Exome Families & family life Female Genetic Association Studies Genetic Predisposition to Disease Genome-wide association studies Genome-Wide Association Study Genomes Genotype Guatemala Health aspects Health care Health risks Hematology Hispanic Americans Hispanic Americans - genetics Hospitals Humans Infant Infant, Newborn Leukemia Lymphatic leukemia Male Medicine Medicine and Health Sciences Minority & ethnic groups Oncology Pediatrics People and Places Pharmaceutical sciences Polymorphism, Single Nucleotide Population Population genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Public health Single-nucleotide polymorphism Texas Transcription Factors - genetics |
| title | Family-based exome-wide association study of childhood acute lymphoblastic leukemia among Hispanics confirms role of ARID5B in susceptibility |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T15%3A34%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Family-based%20exome-wide%20association%20study%20of%20childhood%20acute%20lymphoblastic%20leukemia%20among%20Hispanics%20confirms%20role%20of%20ARID5B%20in%20susceptibility&rft.jtitle=PloS%20one&rft.au=Archer,%20Natalie%20P&rft.date=2017-08-17&rft.volume=12&rft.issue=8&rft.spage=e0180488&rft.pages=e0180488-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0180488&rft_dat=%3Cgale_plos_%3EA501760023%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1930442016&rft_id=info:pmid/28817678&rft_galeid=A501760023&rft_doaj_id=oai_doaj_org_article_66ee2b0dd9024e2a833cc9b23e7f6b6b&rfr_iscdi=true |